| Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control. | Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control.
Yoo HS, Cockrum MA, Napoli JL., Free PMC Article | 06/12/2023 |
| Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period. | Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Ji WH, Li DD, Wei DP, Gu AQ, Yang Y, Peng JP., Free PMC Article | 02/12/2022 |
| Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice. | Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
Snyder JM, Zhong G, Hogarth C, Huang W, Topping T, LaFrance J, Palau L, Czuba LC, Griswold M, Ghiaur G, Isoherranen N., Free PMC Article | 05/1/2021 |
| findings demonstrate that despite lacking a major impact on endogenous all-trans-retinoic acid (atRA) signaling, Cyp26a1 critically contributes as a barrier for exogenous atRA exposure | The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance.
Zhong G, Hogarth C, Snyder JM, Palau L, Topping T, Huang W, Czuba LC, LaFrance J, Ghiaur G, Isoherranen N., Free PMC Article | 04/4/2020 |
| Loss of Strap selectively induced Cyp26A1 expression in mouse EBs, suggesting a potential role of STRAP in RA signaling. | Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis.
Jin L, Chang C, Pawlik KM, Datta A, Johnson LM, Vu T, Napoli JL, Datta PK. | 12/7/2019 |
| We found that developing teeth from K14-CRE/Shhf/f mutant mice exhibit severe downregulation of Cyp26a1 and Cyp26c1 expression levels in the inner dental epithelium | Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.
El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A., Free PMC Article | 08/31/2019 |
| These findings provide a new line of evidence correlating the deleterious effects of blocking CYP26A1 in pregnancy with the aberrant regulation of NK cells in the uterus. | Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.
Meng CY, Li ZY, Fang WN, Song ZH, Yang DD, Li DD, Yang Y, Peng JP., Free PMC Article | 08/12/2017 |
| Cyp26a1, which encodes a key enzyme for catabolic inactivation of retinoic acid (RA) required for tight control of local RA concentrations, is significantly downregulated in embryos of diabetic mice. Embryonic tissues expressing Cyp26a1 show reduced efficiency of RA clearance. | Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes.
Lee LM, Leung MB, Kwok RC, Leung YC, Wang CC, McCaffery PJ, Copp AJ, Shum AS., Free PMC Article | 06/24/2017 |
| These results suggest that CYP2R1 and CYP26A1 may play a major role in hepatoblast cell differentiation during the development of the liver. | Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development.
Ochiai W, Hirose A, Kawamura T, Komachi K, Yamamoto Y, Kitaoka S, Hatogai J, Kusunoki Y, Kon R, Ikarashi N, Sugiyama K. | 01/28/2017 |
| The results of this study suggest that CYP2R1 and CYP26A1 are important in the differentiation of oval cells into hepatoblast-like cells in the injured liver | Analysis of CYP2R1 and CYP26A1 Expression Patterns in Regeneration in Mice with Liver Injury.
Hirose A, Ochiai W, Yamamoto Y, Fukaya M, Iwasaki H, Wakui N, Takahashi A, Takahashi Y, Kitaoka S, Hatogai J, Ikarashi N, Sugiyama K. | 01/28/2017 |
| deletion of both Cyp26a1 and Cyp26b1 in either sertoli or germ cells resulted in increased vacuolization within the seminiferous tubules, delayed spermatid release, and an increase in the number of STRA8-positive spermatogonia | CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis.
Hogarth CA, Evans E, Onken J, Kent T, Mitchell D, Petkovich M, Griswold MD., Free PMC Article | 04/9/2016 |
| Analysis of retinoic-responsive genes, such as Cyp26a1 in embryos suggests that beta-carotene cleavage results in the production of retinoic acid which then can be used by the embryo during severe vitamin A deficiency. | Embryonic phenotype, β-carotene and retinoid metabolism upon maternal supplementation of β-carotene in a mouse model of severe vitamin A deficiency.
Wassef L, Spiegler E, Quadro L., Free PMC Article | 01/18/2014 |
| The cytochrome P450 enzyme Cyp26a1, which metabolizes all-trans-retinoic acid (RA) and thereby reduces RA levels, plays a crucial role in specifying motor neuron columnar subtypes. | Cytochrome p450 cyp26a1 alters spinal motor neuron subtype identity in differentiating embryonic stem cells.
Ricard MJ, Gudas LJ., Free PMC Article | 12/7/2013 |
| Liver Cyp26a1 activity is increased during pregnancy. | Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy.
Topletz AR, Le HN, Lee N, Chapman JD, Kelly EJ, Wang J, Isoherranen N., Free PMC Article | 07/13/2013 |
| These data demonstrate that uterine cyp26a1 activity is important for the maintenance of pregnancy, especially during the process of blastocyst implantation. | Retinoic acid-metabolizing enzyme cytochrome P450 26a1 (cyp26a1) is essential for implantation: functional study of its role in early pregnancy.
Han BC, Xia HF, Sun J, Yang Y, Peng JP. | 05/10/2010 |
| Fluconazole exposure was associated with an up-regulation of CYP26a1 in mouse embryos. | Fluconazole alters CYP26 gene expression in mouse embryos.
Tiboni GM, Marotta F, Carletti E. | 01/21/2010 |
| LRAT acts together with Cyp26A1, one of the enzymes that catalyze the degradation of retinoic acid, and possibly with STRA6, the recently identified cell surface receptor for retinol-RBP | Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis.
Kim YK, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L., Free PMC Article | 01/21/2010 |
| Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. | Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis.
Abu-Abed S, MacLean G, Fraulob V, Chambon P, Petkovich M, Dollé P. | 01/21/2010 |
| Activity of CYP26A1 and CYP26C1 is required for correct A-P patterning and production of migratory cranial neural crest cells in the developing mammalian brain. | CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.
Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, Sakai Y. | 01/21/2010 |
| The identification of a functional retinoic acid response element located 2.0 kb upstream of the Cyp26A1 transcriptional start site is reported. | Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility.
Loudig O, Maclean GA, Dore NL, Luu L, Petkovich M., Free PMC Article | 01/21/2010 |
| Cyp26a1(-/-) mouse fetuses have lethal morphogenetic phenotypes mimicking those generated by excess retinoic acid administration. | Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.
Niederreither K, Abu-Abed S, Schuhbaur B, Petkovich M, Chambon P, Dollé P. | 01/21/2010 |
| in RAC65 cells, RARbeta 2 is transcriptionally repressed as well as Cyp26a1; Cyp26a1-regulated retinoic acid metabolism likely represents critical differentiation swtich in embryocarcinoma cells | RAR-mediated epigenetic control of the cytochrome P450 Cyp26a1 in embryocarcinoma cells.
Pozzi S, Rossetti S, Bistulfi G, Sacchi N. | 01/21/2010 |
| Cyp26a1 degrades retinoic acid within the equatorial retina during later eye development. | CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development.
Sakai Y, Luo T, McCaffery P, Hamada H, Dräger UC. | 01/21/2010 |
| Ablation of the gene for RARgamma (Rarg) rescues Cyp26a1-null mutant animals from caudal regression and embryonic lethality. | Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1.
Abu-Abed S, Dollé P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M. | 01/21/2010 |
| Expression of CYP26A1 in endometrial epithelial cells is regulated by progesterone and not significantly influenced by co-administration of estrogen. | Regulation of expression of the retinoic acid metabolizing enzyme CYP26A1 in uteri of ovariectomized mice after treatment with ovarian steroid hormones.
Fritzsche B, Vermot J, Neumann U, Schmidt A, Schweigert FJ, Dollé P, Rühl R. | 01/21/2010 |