| Ablation of DGKalpha facilitates alpha-smooth muscle actin expression via the Smad and PKCdelta signaling pathways during the acute phase of CCl4 -induced hepatic injury. | Ablation of DGKα facilitates α-smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl(4) -induced hepatic injury.
Seino K, Nakano T, Tanaka T, Hozumi Y, Topham MK, Goto K, Iseki K., Free PMC Article | 02/12/2024 |
| Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase alpha-Deficient Mice. | Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase α-Deficient Mice.
Kudek MR, Xin G, Alson D, Holzhauer S, Shen J, Kasmani MY, Riese M, Cui W., Free PMC Article | 04/19/2023 |
| Loss of Diacylglycerol Kinase alpha Enhances Macrophage Responsiveness. | Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness.
Manigat LC, Granade ME, Taori S, Miller CA, Vass LR, Zhong XP, Harris TE, Purow BW., Free PMC Article | 01/8/2022 |
| DGK alpha and zeta Activities Control TH1 and TH17 Cell Differentiation. | DGK α and ζ Activities Control T(H)1 and T(H)17 Cell Differentiation.
Yang J, Wang HX, Xie J, Li L, Wang J, Wan ECK, Zhong XP., Free PMC Article | 10/24/2020 |
| results suggest DGKalpha aids in modulating the early immune response of adipose tissue following an acute exposure to high-fat diet, possibly through modulation of acute T-cell action | Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet.
Nascimento EBM, Mannerås-Holm L, Chibalin AV, Björnholm M, Zierath JR., Free PMC Article | 07/20/2019 |
| this study shows that diacylglycerol kinase alpha is involved in the vitamin E-induced amelioration of diabetic nephropathy in mice | Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice.
Hayashi D, Yagi K, Song C, Ueda S, Yamanoue M, Topham M, Suzaki T, Saito N, Emoto N, Shirai Y., Free PMC Article | 01/26/2019 |
| Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) | Diacylglycerol kinases in cancer.
Mérida I, Torres-Ayuso P, Ávila-Flores A, Arranz-Nicolás J, Andrada E, Tello-Lafoz M, Liébana R, Arcos R. | 11/18/2017 |
| Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic. | Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.
Mazzeo C, Calvo V, Alonso R, Mérida I, Izquierdo M., Free PMC Article | 09/10/2016 |
| Diacylglycerol kinase alpha establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse. | Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.
Chauveau A, Le Floc'h A, Bantilan NS, Koretzky GA, Huse M., Free PMC Article | 05/16/2015 |
| It plays a role in pathogenesis of various disorders in the central nervous system. | The roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice.
Ishisaka M, Hara H. | 10/4/2014 |
| Ovalbumin-induced airway inflammation was inhibited after DGKalpha DNA vaccine administation. | DGKα DNA vaccine relieves airway allergic inflammation in asthma model possibly via induction of T cell anergy.
Wang Y, Zhang Q, Ma Q, Zhang Y, Li Z, Wang C., Free PMC Article | 07/19/2014 |
| Data indicate that combined deletion of dgkzeta and dgkalpha markedly enhances T-cell responses. | Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.
Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM., Free PMC Article | 08/31/2013 |
| The data strongly supported a role for FoxO proteins in promoting high diacylglycerol kinase alpha levels and indicate a mechanism by which diacylglycerol kinase alpha function is downregulated during productive T cell responses. | FoxO-dependent regulation of diacylglycerol kinase α gene expression.
Martínez-Moreno M, García-Liévana J, Soutar D, Torres-Ayuso P, Andrada E, Zhong XP, Koretzky GA, Mérida I, Ávila-Flores A., Free PMC Article | 01/5/2013 |
| results suggest that the globular form of adiponectin-induced generation of reactive oxygen species and nitric oxide involves diacylglycerol kinase alpha | Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species.
Kamio N, Akifusa S, Yamashita Y. | 08/6/2011 |
| DAG kinases (DGKs) alpha and zeta, which terminate DAG-mediated signaling, synergistically inhibit TCR-induced mTOR activation by inhibiting the Ras-Mek1/2-Erk/12 pathway | Negative regulation of mTOR activation by diacylglycerol kinases.
Gorentla BK, Wan CK, Zhong XP., Free PMC Article | 06/25/2011 |
| DGKs not only terminate diacylglycerol signaling but also initiate PA signaling in thymocytes to promote positive selection | Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.
Guo R, Wan CK, Carpenter JH, Mousallem T, Boustany RM, Kuan CT, Burks AW, Zhong XP., Free PMC Article | 01/21/2010 |
| Diacylglycerol kinase alpha deficiency causes enhanced T cell activation and confers resistance to anergy induction in vitro and in vivo. | Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.
Olenchock BA, Guo R, Carpenter JH, Jordan M, Topham MK, Koretzky GA, Zhong XP. | 05/9/2008 |
| Diacylglycerol kinase alpha is an anergy-associated molecule that negatively regulates Ras in anergic T cells. | T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.
Zha Y, Marks R, Ho AW, Peterson AC, Janardhan S, Brown I, Praveen K, Stang S, Stone JC, Gajewski TF. | 01/21/2010 |
| regulated by pi 3-kinase activation products | Regulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid products.
Ciprés A, Carrasco S, Merino E, Díaz E, Krishna UM, Falck JR, Martínez-A C, Mérida I. | 01/21/2010 |
| A role for DGK alpha in T cell activation is confirmed by the rapid DGK alpha translocation to the membrane fraction, together with the increase in enzyme activity that follows T cell activation in vivo. | T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.
Sanjuán MA, Pradet-Balade B, Jones DR, Martínez-A C, Stone JC, Garcia-Sanz JA, Mérida I. | 01/21/2010 |