| Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment. | Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment.
Sun J, Cong Q, Sun T, Xi S, Liu Y, Zeng R, Wang J, Zhang W, Gao J, Qian J, Qin S. | 09/21/2023 |
| DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury. | DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury.
Díaz MM, Tsenkina Y, Arizanovska D, Mehlen P, Liebl DJ., Free PMC Article | 03/1/2023 |
| Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype. | Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype.
Thiry L, Lemaire C, Rastqar A, Lemieux M, Peng J, Ferent J, Roussel M, Beaumont E, Fawcett JP, Brownstone RM, Charron F, Bretzner F., Free PMC Article | 04/9/2022 |
| DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. | DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation.
Morcom L, Gobius I, Marsh AP, Suárez R, Lim JW, Bridges C, Ye Y, Fenlon LR, Zagar Y, Douglass AM, Donahoo AS, Fothergill T, Shaikh S, Kozulin P, Edwards TJ, Cooper HM, IRC5 Consortium, Sherr EH, Chédotal A, Leventer RJ, Lockhart PJ, Richards LJ., Free PMC Article | 10/30/2021 |
| Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons. | Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons.
Bourojeni FB, Zeilhofer HU, Kania A., Free PMC Article | 07/3/2021 |
| Revisiting the role of Dcc in visual system development with a novel eye clearing method. | Revisiting the role of Dcc in visual system development with a novel eye clearing method.
Vigouroux RJ, Cesar Q, Chédotal A, Nguyen-Ba-Charvet KT., Free PMC Article | 04/24/2021 |
| Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. | Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus.
Glasgow SD, Wong EW, Thompson-Steckel G, Marcal N, Séguéla P, Ruthazer ES, Kennedy TE., Free PMC Article | 02/6/2021 |
| This is the first study demonstrating the localization of DCC and Netrin-1 in the colonic myenteric plexus of the adult mice and their expression level determining two major neuronal subtypes regulating intestinal motility. | Netrin-1-like-immunoreactivity Coexpresses With DCC and Has a Differential Level in the Myenteric Cholinergic and Nitrergic Neurons of the Adult Mouse Colon.
Ko SY, Price JT, Blatch GL, Nurgali K., Free PMC Article | 04/25/2020 |
| Knockdown of DCC or truncation of its P3 domain dramatically delays neuronal migration and impairs the multipolar-to-bipolar transition of migrating neurons. | DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons.
Zhang JH, Zhao YF, He XX, Zhao Y, He ZX, Zhang L, Huang Y, Wang YB, Hu L, Liu L, Yu HL, Xu JH, Lai MM, Zhao DD, Cui L, Guo WX, Xiong WC, Ding YQ, Zhu XJ. | 11/9/2019 |
| the identification of a large four-generational family that carries a mutation to the axon guidance molecule receptor gene, DCC, enabled us to demonstrate effects on mesocorticolimbic anatomical connectivity, striatal volumes, and personality traits | Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers.
Vosberg DE, Zhang Y, Menegaux A, Chalupa A, Manitt C, Zehntner S, Eng C, DeDuck K, Allard D, Durand F, Dagher A, Benkelfat C, Srour M, Joober R, Lepore F, Rouleau G, Théoret H, Bedell BJ, Flores C, Leyton M., Free PMC Article | 10/26/2019 |
| results demonstrated that mice lacking Dcc expression in the spinal cord had a deficit in nociceptive topognosis | DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans.
da Silva RV, Johannssen HC, Wyss MT, Roome RB, Bourojeni FB, Stifani N, Marsh APL, Ryan MM, Lockhart PJ, Leventer RJ, Richards LJ, Rosenblatt B, Srour M, Weber B, Zeilhofer HU, Kania A. | 06/1/2019 |
| DCC expression in the ventral tegmental area, in both normal development and after drug exposure, was regulated by miR-218. | Non-Contingent Exposure to Amphetamine in Adolescence Recruits miR-218 to Regulate Dcc Expression in the VTA.
Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitogiannis A, Flores C., Free PMC Article | 03/16/2019 |
| this work establishes a novel role for MARCKS in axon dynamics and highlights the necessity of MARCKS as an organizer of DCC signaling at the membrane. | MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.
Brudvig JJ, Cain JT, Schmidt-Grimminger GG, Stumpo DJ, Roux KJ, Blackshear PJ, Weimer JM., Free PMC Article | 12/22/2018 |
| Local spinal cord defects following loss of Dcc cause a hopping gait in mice and may contribute to mirror movements in humans. | Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait.
Peng J, Ferent J, Li Q, Liu M, Da Silva RV, Zeilhofer HU, Kania A, Zhang Y, Charron F. | 11/3/2018 |
| Study results indicate that DCC controls corticospinal tract midline crossing in both humans and mice, and that this process is non cell-autonomous in mice. | Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline.
Welniarz Q, Morel MP, Pourchet O, Gallea C, Lamy JC, Cincotta M, Doulazmi M, Belle M, Méneret A, Trouillard O, Ruiz M, Brochard V, Meunier S, Trembleau A, Vidailhet M, Chédotal A, Dusart I, Roze E., Free PMC Article | 09/1/2018 |
| We show, for the first time, that dopamine axons continue to grow from the striatum to the PFC during adolescence. Importantly, we discover that DCC, a guidance cue receptor, controls the extent of this protracted growth by determining where and when dopamine axons recognize their final target. | DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence.
Reynolds LM, Pokinko M, Torres-Berrío A, Cuesta S, Lambert LC, Del Cid Pellitero E, Wodzinski M, Manitt C, Krimpenfort P, Kolb B, Flores C., Free PMC Article | 07/21/2018 |
| role in normal innervation of the peripheral vestibular system | Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice.
Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA., Free PMC Article | 12/2/2017 |
| Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. | TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.
Plooster M, Menon S, Winkle CC, Urbina FL, Monkiewicz C, Phend KD, Weinberg RJ, Gupton SL., Free PMC Article | 11/18/2017 |
| Together, these results demonstrate that the production of DCC splice variants controlled by NOVA has a crucial function during many stages of commissural neuron development. | NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.
Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z., Free PMC Article | 11/18/2017 |
| Results show that deleted in colorectal cancer receptors contribute to the dynamic refinement of dopamine D1 and D2 receptor expression in striatal regions across adolescence. The age-dependent expression of dopamine receptor in C57BL6 mice shows marked differences from previous characterizations in rats. | Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan.
Pokinko M, Grant A, Shahabi F, Dumont Y, Manitt C, Flores C., Free PMC Article | 11/11/2017 |
| Results suggest that Netrin1/DCC signaling induce neuronal migration in the dorsal spinal cord. | Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.
Junge HJ, Yung AR, Goodrich LV, Chen Z., Free PMC Article | 09/23/2017 |
| Results suggest that Dcc plays an important role in the developmental formation of peripheral and central auditory circuits, and its mutation may contribute to sensorineural hearing loss. | Dcc Mediates Functional Assembly of Peripheral Auditory Circuits.
Kim YJ, Wang SZ, Tymanskyj S, Ma L, Tao HW, Zhang LI., Free PMC Article | 03/11/2017 |
| dcc haploinsufficient mice acquire intracranial self-stimulation behavior and that the parameters of the stimulation are comparable to those observed in wild-type littermates; reduced expression of dcc may dampen the abuse potential of cocaine | dcc Haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking.
Reynolds LM, Gifuni AJ, McCrea ET, Shizgal P, Flores C. | 09/3/2016 |
| Identified the Dcc gene as a novel downstream target of spontaneous calcium activity involved in axon growth. | DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity.
Castillo-Paterna M, Moreno-Juan V, Filipchuk A, Rodríguez-Malmierca L, Susín R, López-Bendito G., Free PMC Article | 04/23/2016 |
| suggest that DCC signaling functions through NCK1 and NCK2 and that both proteins are necessary for the establishment of normal spinal circuits necessary for gait | NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits.
Lane C, Qi J, Fawcett JP. | 12/19/2015 |