| Functional assessment of the V390F mutation in the CCTdelta subunit of chaperonin containing tailless complex polypeptide 1. | Functional assessment of the V390F mutation in the CCTδ subunit of chaperonin containing tailless complex polypeptide 1.
Vallin J, Grantham J., Free PMC Article | 03/5/2022 |
| Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued). | Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued).
Suh BK, Lee SA, Park C, Suh Y, Kim SJ, Woo Y, Nhung TTM, Lee SB, Mun DJ, Goo BS, Choi HS, Kim SJ, Park SK., Free PMC Article | 09/4/2021 |
| The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway. | The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway.
Lee YD, Kim B, Jung S, Kim H, Kim MK, Kwon JO, Song MK, Lee ZH, Kim HH., Free PMC Article | 07/3/2021 |
| that a single mutation in the DCTN1 gene recapitulates symptoms of Perry syndrome patients | Behavioral defects in a DCTN1(G71A) transgenic mouse model of Perry syndrome.
Mishima T, Deshimaru M, Watanabe T, Kubota K, Kinoshita-Kawada M, Yuasa-Kawada J, Takasaki K, Uehara Y, Jinno S, Iwasaki K, Tsuboi Y. | 12/22/2018 |
| our findings demonstrate that p150(Glued) is particularly required to maintain the function and survival of spinal motor neurons during aging | Genetic ablation of dynactin p150(Glued) in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice.
Yu J, Lai C, Shim H, Xie C, Sun L, Long CX, Ding J, Li Y, Cai H., Free PMC Article | 11/10/2018 |
| p75NTR intracellular domain as a retrograde degenerative signal and reveal p150(Glued) deacetylation as a unique mechanism regulating axonal transport | Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150(Glued) Deacetylation by Axonal HDAC1.
Pathak A, Stanley EM, Hickman FE, Wallace N, Brewer B, Li D, Gluska S, Perlson E, Fuhrmann S, Akassoglou K, Bronfman F, Casaccia P, Burnette DT, Carter BD., Free PMC Article | 08/25/2018 |
| a mouse model expressing disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is observed. | Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration.
Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller HP, Rasche V, Ferger B, Dirrig-Grosch S, Soylu-Kucharz R, Petersén A, Walther P, Linkus B, Kassubek J, Wong PC, Ludolph AC, Dupuis L., Free PMC Article | 02/6/2016 |
| These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor. | Arl3 and LC8 regulate dissociation of dynactin from dynein.
Jin M, Yamada M, Arai Y, Nagai T, Hirotsune S. | 10/24/2015 |
| Functional relationships between PIK3C3, dynactin, and AnkB promote axonal transport of organelles and are required for normal axon length. | A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.
Lorenzo DN, Badea A, Davis J, Hostettler J, He J, Zhong G, Zhuang X, Bennett V., Free PMC Article | 02/28/2015 |
| The direct binding of the dynactin subunit p150(Glued) to JIP1 competitively inhibits KHC activation in vitro and disrupts the transport of APP in neurons. | JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.
Fu MM, Holzbaur EL., Free PMC Article | 11/30/2013 |
| These data unveil a previously unrecognized role for the dynein-dynactin motor complex in osteoclast formation and function. | Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption.
Ng PY, Cheng TS, Zhao H, Ye S, Sm Ang E, Khor EC, Feng HT, Xu J, Zheng MH, Pavlos NJ. | 05/25/2013 |
| in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres. | Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF., Free PMC Article | 04/20/2013 |
| Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex. | Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).
Kuh GF, Stockmann M, Meyer-Ohlendorf M, Linta L, Proepper C, Ludolph AC, Bockmann J, Boeckers TM, Liebau S. | 03/16/2013 |
| Melanoregulin interacts with the C-terminal domain of Rab-interacting lysosomal protein (RILP) and forms a complex with RILP and p150(Glued) (also known as dynactin subunit 1, DCTN1), a component of the dynein-dynactin motor complex. | Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Ohbayashi N, Maruta Y, Ishida M, Fukuda M. | 02/16/2013 |
| It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex. | A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y., Free PMC Article | 10/20/2012 |
| Dctn1 plays an important role in mouse spermiogenesis, and mainly affects the formation of the tail of spermatozoa. | [Location of Dctn1 in the mouse testis and sperm and its role in spermiogenesis].
Zheng B, Jiang M, Li SY, Wu YB, Zhu H, Zhou ZM, Sha JH. | 04/21/2012 |
| Alpha-E-catenin functions as a dynamic link between the dynactin complex and actin and, thus, integrates the microtubule and actin cytoskeleton during intracellular trafficking. | Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic.
Lien WH, Gelfand VI, Vasioukhin V., Free PMC Article | 01/21/2010 |
| the N-terminal projection domain of tau binds to the C-terminus of the p150 subunit of the dynactin complex | Interaction of tau protein with the dynactin complex.
Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG., Free PMC Article | 01/21/2010 |
| Novel mechanism of retrograde apoptosis, in which caspase-8 complexes directly with axonal dynactin p150Glued to reveal a differential vulnerability of subpopulations of olfactory recepetor neurons to undergo apoptosis. | Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis.
Carson C, Saleh M, Fung FW, Nicholson DW, Roskams AJ., Free PMC Article | 01/21/2010 |