| Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion. | Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
Chen X, Wang C, Zhao G, Li Z, Zhang W, Song T, Zhang C, Duan N. | 04/5/2024 |
| Dnmt2-null sperm block maternal transmission of a paramutant phenotypedagger. | Dnmt2-null sperm block maternal transmission of a paramutant phenotype†.
Yu T, Xie Y, Tang C, Wang Y, Yuan S, Zheng H, Yan W., Free PMC Article | 01/8/2022 |
| We also show that Q-dependent stimulation of Dnmt2 is conserved in mice. Our findings reveal a direct mechanism for the regulation of translational speed and fidelity in eukaryotes by a nutrient originating from bacteria. | Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Müller M, Legrand C, Tuorto F, Kelly VP, Atlasi Y, Lyko F, Ehrenhofer-Murray AE., Free PMC Article | 10/12/2019 |
| Dnmt2 functions as a genetic factor that is essential in shaping the sperm RNA 'coding signature that is responsible for the intergenerational transmission of HFD-induced paternal metabolic disorders. | Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q., Free PMC Article | 04/13/2019 |
| Dnmt2 may promote lifespan in the control conditions and survival during stress conditions in mouse fibroblasts. | Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts.
Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Wnuk M. | 10/7/2017 |
| Dnmt2 plays an unexpected role for regulation of cardiac growth by modulating activity of the P-TEFb complex. | Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth.
Ghanbarian H, Wagner N, Polo B, Baudouy D, Kiani J, Michiels JF, Cuzin F, Rassoulzadegan M, Wagner KD., Free PMC Article | 08/12/2017 |
| Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2) siRNA restored the expression of Atg5 and LC3 in vivo and in vitro. | Aging is associated with hypermethylation of autophagy genes in macrophages.
Khalil H, Tazi M, Caution K, Ahmed A, Kanneganti A, Assani K, Kopp B, Marsh C, Dakhlallah D, Amer AO., Free PMC Article | 05/27/2017 |
| Dnmt2 plays an important role in haematopoiesis and define a novel function of C38 tRNA methylation in the discrimination of near-cognate codons, thereby ensuring accurate polypeptide synthesis. | The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.
Tuorto F, Herbst F, Alerasool N, Bender S, Popp O, Federico G, Reitter S, Liebers R, Stoecklin G, Gröne HJ, Dittmar G, Glimm H, Lyko F., Free PMC Article | 12/5/2015 |
| these findings uncover a novel function of Dnmt2 in RNA-mediated epigenetic heredity | RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.
Kiani J, Grandjean V, Liebers R, Tuorto F, Ghanbarian H, Lyko F, Cuzin F, Rassoulzadegan M., Free PMC Article | 09/14/2013 |
| Dnmt2-dependent methylomes lack defined DNA methylation patterns. | Dnmt2-dependent methylomes lack defined DNA methylation patterns.
Raddatz G, Guzzardo PM, Olova N, Fantappié MR, Rampp M, Schaefer M, Reik W, Hannon GJ, Lyko F., Free PMC Article | 08/10/2013 |
| Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis. | RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.
Tuorto F, Liebers R, Musch T, Schaefer M, Hofmann S, Kellner S, Frye M, Helm M, Stoecklin G, Lyko F. | 11/17/2012 |
| the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection. | The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress.
Thiagarajan D, Dev RR, Khosla S. | 04/30/2011 |