| Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-kappaB signaling in keratinocyte. | Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
Fang Z, Wang Y, Huang B, Chen X, Jiang R, Yin M., Free PMC Article | 09/28/2023 |
| Author report an unexpected pro-apoptotic activity of EDAR when unbound to its ligand Eda-A1, which is independent of NF-kappaB pathway. Contrarily to other death receptors, EDAR does recruit caspase-8 to trigger apoptosis but solely upon ligand withdrawal, thereby behaving as the so-called dependence receptors. | The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.
Vial J, Royet A, Cassier P, Tortereau A, Dinvaut S, Maillet D, Gratadou-Hupon L, Creveaux M, Sadier A, Tondeur G, Léon S, Depaepe L, Pantalacci S, de la Fouchardière A, Micheau O, Dalle S, Laudet V, Mehlen P, Castets M., Free PMC Article | 06/6/2020 |
| broad activation of Edar expression precedes its spatial restriction to tooth signaling centers. | Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning.
Sadier A, Twarogowska M, Steklikova K, Hayden L, Lambert A, Schneider P, Laudet V, Hovorakova M, Calvez V, Pantalacci S., Free PMC Article | 11/9/2019 |
| EDAR protein signaling pathway plays an important role in wound healing in mice and human. | Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair.
Garcin CL, Huttner KM, Kirby N, Schneider P, Hardman MJ., Free PMC Article | 09/16/2017 |
| Mouse models with HED also carry Eda, Edar or Edaradd mutations and have defects that map to the same structures.We report that otitis media, rhinitis and nasopharyngitis occur at high frequency in Eda and Edar mutant mice and explore the pathogenic mechanisms related to glandular function, microbial and immune parameters in these lines | Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology.
Azar A, Piccinelli C, Brown H, Headon D, Cheeseman M., Free PMC Article | 07/15/2017 |
| Edar is expressed in the developing ear. Edar-deficient mice have an abnormally shaped pinna. | A genome-wide association study identifies multiple loci for variation in human ear morphology.
Adhikari K, Reales G, Smith AJ, Konka E, Palmen J, Quinto-Sanchez M, Acuña-Alonzo V, Jaramillo C, Arias W, Fuentes M, Pizarro M, Barquera Lozano R, Macín Pérez G, Gómez-Valdés J, Villamil-Ramírez H, Hunemeier T, Ramallo V, Silva de Cerqueira CC, Hurtado M, Villegas V, Granja V, Gallo C, Poletti G, Schuler-Faccini L, Salzano FM, Bortolini MC, Canizales-Quinteros S, Rothhammer F, Bedoya G, Calderón R, Rosique J, Cheeseman M, Bhutta MF, Humphries SE, Gonzalez-José R, Headon D, Balding D, Ruiz-Linares A., Free PMC Article | 04/9/2016 |
| Edar signalling has pleiotropic effects on craniofacial and cutaneous glands | Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands.
Chang SH, Jobling S, Brennan K, Headon DJ., Free PMC Article | 03/15/2010 |
| These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes. | Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.
Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R., Free PMC Article | 01/21/2010 |
| Salivary gland branching morphogenesis: a quantitative systems analysis of the Edar | Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.
Melnick M, Phair RD, Lapidot SA, Jaskoll T., Free PMC Article | 01/21/2010 |
| results indicate that unknown mechanisms of the Eda pathway are implicated in tooth morphogenesis | Distinct impacts of Eda and Edar loss of function on the mouse dentition.
Charles C, Pantalacci S, Tafforeau P, Headon D, Laudet V, Viriot L., Free PMC Article | 01/21/2010 |
| Eda is the main activator of NF-kappaB signalling in developing skin appendages and surprisingly that the functional overlap of Troy and Eda signalling pathways is mediated by NF-kappaB independent pathways | Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.
Pispa J, Pummila M, Barker PA, Thesleff I, Mikkola ML. | 01/21/2010 |
| Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 in embryonic eda(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway. | Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.
Fliniaux I, Mikkola ML, Lefebvre S, Thesleff I. | 01/21/2010 |
| Analysis of expression patterns of eda, edar and tnfrsf19 in mouse embryogenesis. | Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis.
Pispa J, Mikkola ML, Mustonen T, Thesleff I. | 01/21/2010 |
| demonstrate that epidermal NF-kappaB activity is first observed in placodes of primary guard hair follicles at day E14.5, and that in vivo NF-kappaB signalling is activated downstream of Eda A1 and EdaR | NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth.
Schmidt-Ullrich R, Tobin DJ, Lenhard D, Schneider P, Paus R, Scheidereit C. | 01/21/2010 |
| Data show that Edar misexpression disrupts tooth patterning and differentiation. | Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar.
Pispa J, Mustonen T, Mikkola ML, Kangas AT, Koppinen P, Lukinmaa PL, Jernvall J, Thesleff I. | 01/21/2010 |
| Edar expression is confined to the ectoderm and occurs in a pattern that suggests a role of ectodysplasin/Edar signaling in the interactions between the ectodermal compartments and the formation and function of hair placodes. | Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.
Laurikkala J, Pispa J, Jung HS, Nieminen P, Mikkola M, Wang X, Saarialho-Kere U, Galceran J, Grosschedl R, Thesleff I. | 01/21/2010 |
| Thus, our data demonstrate that in addition to its well-established role in HF morphogenesis, Edar signaling is also involved in hair cycle control and regulates apoptosis in HF keratinocytes during catagen. | Involvement of the Edar signaling in the control of hair follicle involution (catagen).
Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA., Free PMC Article | 01/21/2010 |
| isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR | Repertoire of mouse ectodysplasin-A (EDA-A) isoforms.
Hashimoto T, Cui CY, Schlessinger D. | 01/21/2010 |
| Data show that ectodysplasin receptor (Edar)-bone morphogenetic protein (BMP)-4 and -7 signaling and transcriptional interactions are central to generation of the primary hair follicle pattern. | Generation of the primary hair follicle pattern.
Mou C, Jackson B, Schneider P, Overbeek PA, Headon DJ., Free PMC Article | 01/21/2010 |