| Thrombin activatable fibrinolysis inhibitor plasma levels and TAFI Thr325Ile genetic polymorphism in a cohort of Egyptian sickle cell disease patients and impact on disease severity. | Thrombin activatable fibrinolysis inhibitor plasma levels and TAFI Thr325Ile genetic polymorphism in a cohort of Egyptian sickle cell disease patients and impact on disease severity.
Hamdy M, Shaheen IA, Khallaf M, Selim YMM. | 04/29/2024 |
| A challenging issue in COVID-19 infection: The relationship between PA1-1 and TAFI levels in patients with coagulation disorder: A retrospective and observational study. | A challenging issue in COVID-19 infection: The relationship between PA1-1 and TAFI levels in patients with coagulation disorder: A retrospective and observational study.
Altin N, Tiğlioğlu P, Ulusoy TU, Aydin FN, Kar İ, Karakoc B, Utebey G., Free PMC Article | 04/17/2024 |
| Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion. | Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion.
Wang Y, Cheng W, Chen X, Cheng C, Zhang L, Huang W. | 02/23/2024 |
| Plasma thrombin-activatable fibrinolysis inhibitor and the 1040C/T polymorphism are risk factors for diabetic kidney disease in Chinese patients with type 2 diabetes. | Plasma thrombin-activatable fibrinolysis inhibitor and the 1040C/T polymorphism are risk factors for diabetic kidney disease in Chinese patients with type 2 diabetes.
Huang Q, Feng D, Pan L, Wang H, Wu Y, Zhong B, Gong J, Lin H, Fei X., Free PMC Article | 12/1/2023 |
| Association between TAFI and PAI-1 polymorphisms with biochemical and hemostatic parameters in polycystic ovary syndrome. | Association between TAFI and PAI-1 polymorphisms with biochemical and hemostatic parameters in polycystic ovary syndrome.
Albuquerque JC, Luz NMC, Ribeiro THO, Costa LBX, Candido AL, Reis FM, Reis HJ, Silva FS, Silva IFO, Gomes KB, Ferreira CN. | 03/23/2023 |
| ProCPU Is Expressed by (Primary) Human Monocytes and Macrophages and Expression Differs between States of Differentiation and Activation. | ProCPU Is Expressed by (Primary) Human Monocytes and Macrophages and Expression Differs between States of Differentiation and Activation.
Claesen K, De Loose J, Van Wielendaele P, De Bruyn E, Sim Y, Thys S, De Meester I, Hendriks D., Free PMC Article | 03/23/2023 |
| Carboxypeptidase U (TAFIa) Is Rapidly Activated and Deactivated Following Thrombolysis and Thrombectomy in Stroke Patients. | Carboxypeptidase U (TAFIa) Is Rapidly Activated and Deactivated Following Thrombolysis and Thrombectomy in Stroke Patients.
Mertens JC, Blanc-Guillemaud V, Claesen K, Cardona P, Hendriks D, Tyl B, Molina CA. | 11/5/2022 |
| Relationship Between Polymorphism of Thrombin-Activatable Fibrinolysis Inhibitor Gene +1040C/T and a Cohort of Chinese Women With Recurrent Spontaneous Abortion. | Relationship Between Polymorphism of Thrombin-Activatable Fibrinolysis Inhibitor Gene +1040C/T and a Cohort of Chinese Women With Recurrent Spontaneous Abortion.
Fang P, Cai D, Du L, Shen F, Zhang C, Li M., Free PMC Article | 02/12/2022 |
| Fibrinogen and Antifibrinolytic Proteins: Interactions and Future Therapeutics. | Fibrinogen and Antifibrinolytic Proteins: Interactions and Future Therapeutics.
Pechlivani N, Kearney KJ, Ajjan RA., Free PMC Article | 12/18/2021 |
| Combining genetic effect in recurrent spontaneous abortion of vascular endothelial growth factor, endothelial nitric oxide synthase and thrombin-activatable fibrinolysis inhibitor genetic polymorphisms. | The prevalence of combined vascular endothelial growth factor, endothelial nitric oxide synthase and thrombin-activatable fibrinolysis inhibitor genetic polymorphisms among Egyptian patients with recurrent spontaneous abortion.
Abulata NN, Shaheen IA, Osman OM, Hussein AM, El-Khayat WM. | 01/11/2020 |
| TAFI is highly expressed in endometriosis and causes epithelial mesenchymal transition (EMT), which accelerated the cell proliferation and cell invasion. | Overexpression of TAFI promotes epithelial mesenchymal transition in endometriosis.
Cai Y, Jin H, Cao LQ, Gao Q, Tao J. | 08/24/2019 |
| ProCPU is increased in CSF during hyperacute ischemic stroke and is associated with stroke progression and outcome after 3 months, most likely due to BBB dysfunction in the hyperacute phase of ischemic stroke. | Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction.
Mertens JC, Leenaerts D, Brouns R, Engelborghs S, Ieven M, De Deyn PP, Lambeir AM, Hendriks D. | 06/29/2019 |
| CPB2 positively correlates with IL10 mRNA expression, incidence of CD14(+) cells and lymphovascular invasion in inflammatory breast cancer (IBC) patients. IL-10 stimulated CPB2 expression in Triple negative-IBC cell line suggests a relevant role of CPB2 in the aggressive phenotype of IBC. | IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages.
Mohamed HT, El-Husseiny N, El-Ghonaimy EA, Ibrahim SA, Bazzi ZA, Cavallo-Medved D, Boffa MB, El-Shinawi M, Mohamed MM. | 04/27/2019 |
| CPB2 is the primary determinant of TAFI concentrations in the Swedish population | A Genome-wide Study of Common and Rare Genetic Variants Associated with Circulating Thrombin Activatable Fibrinolysis Inhibitor.
Stanne TM, Olsson M, Lorentzen E, Pedersen A, Gummesson A, Gils A, Jood K, Engström G, Melander O, Declerck PJ, Jern C., Free PMC Article | 04/13/2019 |
| This study investigated the associations of coagulation factors and inhibitors, TAFI and global haemostatic tests with the bleeding phenotype, as well as the response to treatment with factor concentrate in a patient cohort with haemophilia A. Presence of thrombophilia and levels of coagulation factors, coagulation inhibitors and TAFI do not affect global haemostasis or bleeding phenotype in patients with haemophilia | Presence of thrombophilia and levels of coagulation factors, coagulation inhibitors and TAFI do not affect global haemostasis or bleeding phenotype in patients with haemophilia A.
Mikovic D, Pruner I, Antovic JP, Chaireti R. | 03/9/2019 |
| First study of association of TAFI polymorphisms with coronary stenosis severity. Significant association between TAFI 505G/A and +1583T/A and high Gensini score. TAFI polymorphisms seem to contribute to atherosclerotic plaque progression. | Association of TAFI gene polymorphisms with severity of coronary stenosis in stable coronary artery disease.
Rattanawan C, Komanasin N, Settasatian N, Settasatian C, Kukongviriyapan U, Intharapetch P, Senthong V. | 01/19/2019 |
| TAFI 1040C/T could not be considered a molecular predictive factor for Recurrent spontaneous abortion in Egyptians. | Thrombin-Activatable Fibrinolysis Inhibitor Gene Polymorphism (TAFI1040C/T) in Women With Recurrent Spontaneous Abortion.
ElDanasori N, Abulata N, Shaheen IA, ElGendy AM, El-Khayat W., Free PMC Article | 09/15/2018 |
| TAFI and TAFIa levels were increased in patients with APS as a potential response to complement activation. Interestingly, TAFI activation was associated with arterial thrombotic APS manifestations. | Thrombin activatable fibrinolysis inhibitor (TAFI) - A possible link between coagulation and complement activation in the antiphospholipid syndrome (APS).
Grosso G, Vikerfors A, Woodhams B, Adam M, Bremme K, Holmström M, Ågren A, Eelde A, Bruzelius M, Svenungsson E, Antovic A. | 08/11/2018 |
| Reprot altered in vivo TAFI activation in patients with abdominal aortic aneurysms, as shown by the increased plasma levels of TAFI(activated)/TAFIai(inactivated) and TAFI-activation peptide. | Thrombin-activatable fibrinolysis inhibitor in human abdominal aortic aneurysm disease.
Bridge KI, Bollen L, Zhong J, Hesketh M, Macrae FL, Johnson A, Philippou H, Scott DJ, Gils A, Ariёns RAS. | 07/7/2018 |
| Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-thrombomodulin complex, which modulates its antifibrinolytic potential. | Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.
Wu C, Stafford AR, Fredenburgh JC, Weitz JI, Gils A, Declerck PJ, Kim PY. | 05/5/2018 |
| CPU generation during in vitro clot lysis follows a biphasic pattern in pooled plasma. A first CPU activity peak is mediated by the action of thrombin-(thrombomodulin), a second by the action of plasmin. | Plasma carboxypeptidase U (CPU, CPB2, TAFIa) generation during in vitro clot lysis and its interplay between coagulation and fibrinolysis.
Leenaerts D, Aernouts J, Van Der Veken P, Sim Y, Lambeir AM, Hendriks D. | 05/5/2018 |
| The data suggested that suppression of TAFI by siRNA inhibits invasion and migration of breast cancer cells and that TAFI may be a new target for breast cancer therapy. | Suppression of TAFI by siRNA inhibits invasion and migration of breast cancer cells.
Yu C, Luan Y, Wang Z, Zhao J, Xu C. | 04/28/2018 |
| Report direct crosstalk between coagulation and fibrinolysis, which takes place on activated platelets' surface that is further controlled by thrombin-activatable fibrinolysis inhibitor (TAFI). | Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by thrombin-activatable fibrinolysis inhibitor.
Brzoska T, Suzuki Y, Sano H, Suzuki S, Tomczyk M, Tanaka H, Urano T. | 03/3/2018 |
| The current study revealed a significant increase level of TAFI and PAI-1, coupled with a decrease in PAI-2 in women with severe preeclampsia in comparison with the control group. | Fibrinolysis parameters in Sudanese women with severe preeclampsia.
Elzein HO, Muddathir AR, Rida M, Rayis DA, Elhassan EM, Adam I. | 02/3/2018 |
| The abundance of free PAI-1 and TAFI in the plaque may inhibit plasmin generation and thereby counteract plaque destabilization by fibrinolysis, cell migration and inflammation | Fibrinolysis inhibitors in plaque stability: a morphological association of PAI-1 and TAFI in advanced carotid plaque.
Jönsson Rylander AC, Lindgren A, Deinum J, Bergström GM, Böttcher G, Kalies I, Wåhlander K. | 02/3/2018 |