| Sphingosine-1-Phosphate Receptor 4 links neutrophils and early local inflammation to lymphocyte recruitment into the draining lymph node to facilitate robust germinal center formation. | Sphingosine-1-Phosphate Receptor 4 links neutrophils and early local inflammation to lymphocyte recruitment into the draining lymph node to facilitate robust germinal center formation.
Luker AJ, Wukitch A, Kulinski JM, Ganesan S, Kabat J, Lack J, Frischmeyer-Guerrerio P, Metcalfe DD, Olivera A., Free PMC Article | 10/4/2024 |
| Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4. | Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
Kurano M, Uranbileg B, Yatomi Y. | 09/22/2023 |
| Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation. | Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
Wang S, Tian Z, Lu Y, Huang Z, Fan Y, Li B, Zheng H, Wu X, Wang M, Zhao J, Xie J., Free PMC Article | 04/19/2023 |
| Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome. | Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.
Hong CH, Ko MS, Kim JH, Cho H, Lee CH, Yoon JE, Yun JY, Baek IJ, Jang JE, Lee SE, Cho YK, Baek JY, Oh SJ, Lee BY, Lim JS, Lee J, Hartig SM, Conde de la Rosa L, Garcia-Ruiz C, Lee KU, Fernández-Checa JC, Choi JW, Kim S, Koh EH., Free PMC Article | 04/16/2022 |
| Sphingosine-1-Phosphate Receptor Type 4 (S1P4) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions. | Sphingosine-1-Phosphate Receptor Type 4 (S1P(4)) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions.
Riese J, Gromann A, Lührs F, Kleinwort A, Schulze T., Free PMC Article | 07/10/2021 |
| S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion. | S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.
Olesch C, Sirait-Fischer E, Berkefeld M, Fink AF, Susen RM, Ritter B, Michels BE, Steinhilber D, Greten FR, Savai R, Takeda K, Brüne B, Weigert A., Free PMC Article | 02/20/2021 |
| S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model. | S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model.
Schuster C, Huard A, Sirait-Fischer E, Dillmann C, Brüne B, Weigert A. | 12/12/2020 |
| Genetic deletion of S1pr4 resulted in exacerbation of passive systemic anaphylaxis to IgE/anti-IgE. | S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells.
Kulinski JM, Proia RL, Larson EM, Metcalfe DD, Olivera A., Free PMC Article | 09/15/2018 |
| Data shows a reduced abundance of pDC, particularly CD4- pDC, in all organs of S1PR4-deficient vs. wildtype mice. | S1PR4 is required for plasmacytoid dendritic cell differentiation.
Dillmann C, Mora J, Olesch C, Brüne B, Weigert A. | 02/6/2016 |
| analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists | Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.
Guerrero M, Urbano M, Zhao J, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E., Free PMC Article | 08/4/2012 |
| S1P4 signaling is involved in the regulation of dendritic cell function and TH17 T-cell differentiation. S1P4-mediated S1P signaling also modifies the course of various immune diseases in a murine model | Sphingosine-1-phospate receptor 4 (S1P₄) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model.
Schulze T, Golfier S, Tabeling C, Räbel K, Gräler MH, Witzenrath M, Lipp M. | 12/31/2011 |
| Megakaryocytes generated from S1P(4)-deficient murine bone marrow showed atypical and reduced formation of proplatelets in vitro. | Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4.
Golfier S, Kondo S, Schulze T, Takeuchi T, Vassileva G, Achtman AH, Gräler MH, Abbondanzo SJ, Wiekowski M, Kremmer E, Endo Y, Lira SA, Bacon KB, Lipp M. | 01/8/2011 |
| S1P4 mediates immunosuppressive effects of S1P by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10 | Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration.
Wang W, Graeler MH, Goetzl EJ. | 01/21/2010 |
| s1p(4) maps to mouse chromosome 10 and has similar tissue distribution to mouse Gna15; transcription of the two genes may be under control of the same enhancer elements | Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.
Contos JJ, Ye X, Sah VP, Chun J. | 01/21/2010 |
| binding pocket of mS1P4 (mouse S1P4) has recognition sites for the anionic phosphate and cationic ammonium groups that are equidistant from the end of the non-polar tail | Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.
Inagaki Y, Pham TT, Fujiwara Y, Kohno T, Osborne DA, Igarashi Y, Tigyi G, Parrill AL., Free PMC Article | 01/21/2010 |