| PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1. | PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
Zhang Z, Liu R, Zhou H, Li Q, Qu R, Wang W, Zhou Z, Yu R, Zeng Y, Mu J, Chen B, Guo X, Sang Q, Wang L. | 06/22/2023 |
| miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice. | miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice.
Ke X, Deng M, Wu Z, Yu H, Yu D, Li H, Lu Y, Shu K, Pei L., Free PMC Article | 02/16/2023 |
| Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland. | Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland.
Preston SEJ, Bartish M, Richard VR, Aghigh A, Gonçalves C, Smith-Voudouris J, Huang F, Thébault P, Cleret-Buhot A, Lapointe R, Légaré F, Postovit LM, Zahedi RP, Borchers CH, Miller WH Jr, Del Rincón SV. | 09/17/2022 |
| Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy. | Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy.
Roy A, Kumar A., Free PMC Article | 05/14/2022 |
| mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation. | mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
Jana S, Deo R, Hough RP, Liu Y, Horn JL, Wright JL, Lam HM, Webster KR, Chiang GG, Sonenberg N, Hsieh AC., Free PMC Article | 02/19/2022 |
| Pumilio2 Promotes Growth of Mature Neurons. | Pumilio2 Promotes Growth of Mature Neurons.
Schieweck R, Schöneweiss EC, Harner M, Rieger D, Illig C, Saccà B, Popper B, Kiebler MA., Free PMC Article | 10/2/2021 |
| Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses. | Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
Huang F, Gonçalves C, Bartish M, Rémy-Sarrazin J, Issa ME, Cordeiro B, Guo Q, Emond A, Attias M, Yang W, Plourde D, Su J, Gimeno MG, Zhan Y, Galán A, Rzymski T, Mazan M, Masiejczyk M, Faber J, Khoury E, Benoit A, Gagnon N, Dankort D, Journe F, Ghanem GE, Krawczyk CM, Saragovi HU, Piccirillo CA, Sonenberg N, Topisirovic I, Rudd CE, Miller WH Jr, Del Rincón SV., Free PMC Article | 10/2/2021 |
| The distribution of eukaryotic initiation factor 4E after bouts of resistance exercise is altered by shortening of recovery periods. | The distribution of eukaryotic initiation factor 4E after bouts of resistance exercise is altered by shortening of recovery periods.
Takegaki J, Ogasawara R, Kouzaki K, Fujita S, Nakazato K, Ishii N., Free PMC Article | 09/11/2021 |
| Regulation of the mammalian maternal-to-embryonic transition by eukaryotic translation initiation factor 4E. | Regulation of the mammalian maternal-to-embryonic transition by eukaryotic translation initiation factor 4E.
Li Y, Tang J, Ji X, Hua MM, Liu M, Chang L, Gu Y, Shi C, Ni W, Liu J, Shi HJ, Huang X, O'Neill C, Jin X., Free PMC Article | 08/7/2021 |
| eIF4E phosphorylation modulates pain and neuroinflammation in the aged. | eIF4E phosphorylation modulates pain and neuroinflammation in the aged.
Mody PH, Dos Santos NL, Barron LR, Price TJ, Burton MD., Free PMC Article | 05/8/2021 |
| The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity. | The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D., Free PMC Article | 03/20/2021 |
| Phosphorylation of eIF4E at Ser209 is dispensable for skeletal muscle hypertrophy in response to mechanical overload. | Phosphorylation of eukaryotic initiation factor 4E is dispensable for skeletal muscle hypertrophy.
Figueiredo VC, Englund DA, Vechetti IJ Jr, Alimov A, Peterson CA, McCarthy JJ., Free PMC Article | 04/11/2020 |
| phosphorylation pattern of eIF4E responds faithfully to Rapamycin inhibition, the prolonged exposure to Rapamycin rescues the loss of eIF4E phosphorylation through Mnk1 activation. | Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.
Batool A, Majeed ST, Aashaq S, Majeed R, Bhat NN, Andrabi KI. | 03/21/2020 |
| 4E-BP/eIF4E can regulate expression of important proteins necessary for B cell differentiation. Rap reduces eIF4E and eIF4G association to inhibit cap-dependent translation in activated B cells and that directly inhibiting eIF4E activity can also reduce antibody class switching. | The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes.
Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA., Free PMC Article | 10/19/2019 |
| We reveal a novel role for eIF4E phosphorylation in inflammatory responses and depression-like behaviors | Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation.
Amorim IS, Kedia S, Kouloulia S, Simbriger K, Gantois I, Jafarnejad SM, Li Y, Kampaite A, Pooters T, Romanò N, Gkogkas CG., Free PMC Article | 05/25/2019 |
| eIF4E phosphorylation modulates depression-like behavior through regulation of inflammatory responses. | Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.
Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G, Sonenberg N., Free PMC Article | 12/22/2018 |
| eIF4E availability and phosphorylation promote metastasis in mouse models of breast cancer by selectively augmenting the translation of mRNAs involved in invasion and metastasis. | Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.
Robichaud N, Hsu BE, Istomine R, Alvarez F, Blagih J, Ma EH, Morales SV, Dai DL, Li G, Souleimanova M, Guo Q, Del Rincon SV, Miller WH Jr, Ramón Y Cajal S, Park M, Jones RG, Piccirillo CA, Siegel PM, Sonenberg N., Free PMC Article | 11/3/2018 |
| Lack of Def6 results in deregulation of Bcl6 protein synthesis in T cells as a result of enhanced activation of the mTORC1-4E-BP-eIF4E axis. | The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity.
Yi W, Gupta S, Ricker E, Manni M, Jessberger R, Chinenov Y, Molina H, Pernis AB., Free PMC Article | 02/24/2018 |
| Mitogen-activated protein kinase interacting protein kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1, to release translational repression. | Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia.
Kosciuczuk EM, Saleiro D, Platanias LC., Free PMC Article | 01/6/2018 |
| PRMT1 inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5. | Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5.
Zhang B, Zhang S, Zhu L, Chen X, Zhao Y, Chao L, Zhou J, Wang X, Zhang X, Ma N. | 12/16/2017 |
| Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain. | The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.
Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ., Free PMC Article | 08/26/2017 |
| data suggest a physiological role for MNK1a-Ser(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo. | AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.
Zhu X, Dahlmans V, Thali R, Preisinger C, Viollet B, Voncken JW, Neumann D., Free PMC Article | 05/6/2017 |
| Results of our study suggest that the eIF4E/Fmr1 double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder. | eIF4E/Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors.
Huynh TN, Shah M, Koo SY, Faraud KS, Santini E, Klann E., Free PMC Article | 09/17/2016 |
| Our findings identify the eIF4E- beta-catenin axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer. | Antibiotic drug rifabutin is effective against lung cancer cells by targeting the eIF4E-β-catenin axis.
Li J, Huang Y, Gao Y, Wu H, Dong W, Liu L. | 08/13/2016 |
| Unphosphorylated HSP27 associates with eIF4E in osteoblasts and suppresses the translation initiation process. | Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts.
Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Otsuka T. | 05/14/2016 |