| ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma. | ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
Li T, Xu L, Wei Z, Zhang S, Liu X, Yang Y, Gu Y, Zhang J., Free PMC Article | 11/22/2023 |
| The transcription factor ELF5 is essential for early preimplantation development. | The transcription factor ELF5 is essential for early preimplantation development.
Alotaibi H. | 03/17/2023 |
| MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5. | MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
Pickup ME, Hu A, Patel HJ, Ahmed MI. | 02/27/2023 |
| Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland. | Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
Song EAC, Smalley K, Oyelakin A, Horeth E, Che M, Wrynn T, Osinski J, Romano RA, Sinha S., Free PMC Article | 02/23/2023 |
| Downregulation of ELF5 increases the expression of AR-response genes and the progression of prostate cancer. ELF5 interaction with AR is androgen dependent. | ELF5-Mediated AR Activation Regulates Prostate Cancer Progression.
Li K, Guo Y, Yang X, Zhang Z, Zhang C, Xu Y., Free PMC Article | 10/27/2018 |
| Conditional inactivation of Elf5 in the developing collecting ducts results in a small but significant reduction in the expression levels of Aqp2 and Avpr2 genes. | Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
Grassmeyer J, Mukherjee M, deRiso J, Hettinger C, Bailey M, Sinha S, Visvader JE, Zhao H, Fogarty E, Surendran K., Free PMC Article | 06/10/2017 |
| Mechanistically, RL negatively regulates Stat5 phosphorylation and Elf5 expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 pathway. | Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation.
Cordero A, Pellegrini P, Sanz-Moreno A, Trinidad EM, Serra-Musach J, Deshpande C, Dougall WC, Pujana MA, González-Suárez E. | 01/14/2017 |
| Elf5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular switch governing the balance between TSC proliferation and differentiation | Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.
Latos PA, Sienerth AR, Murray A, Senner CE, Muto M, Ikawa M, Oxley D, Burge S, Cox BJ, Hemberger M., Free PMC Article | 04/2/2016 |
| Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner | Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner.
Donnison M, Broadhurst R, Pfeffer PL. | 02/14/2015 |
| Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. | Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression.
Pearton DJ, Smith CS, Redgate E, van Leeuwen J, Donnison M, Pfeffer PL. | 09/20/2014 |
| Blockade of RankL action prevented progesterone-induced side branching and the expansion of Elf5(+) mature luminal cells. | Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.
Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ. | 05/18/2013 |
| Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. | Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.
Chakrabarti R, Hwang J, Andres Blanco M, Wei Y, Lukačišin M, Romano RA, Smalley K, Liu S, Yang Q, Ibrahim T, Mercatali L, Amadori D, Haffty BG, Sinha S, Kang Y., Free PMC Article | 01/26/2013 |
| Studies suggest that Elf5 loss leads to hyperactivation of the Notch signaling pathway, which might constitute in part, the underlying molecular mechanism for the altered cell lineage decisions in Elf5-null mammary epithelial cells. | Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling.
Chakrabarti R, Wei Y, Romano RA, DeCoste C, Kang Y, Sinha S., Free PMC Article | 10/20/2012 |
| Elf5 promoter methylation is regulated during mammary differentiation in vivo. | Lineage specific methylation of the Elf5 promoter in mammary epithelial cells.
Lee HJ, Hinshelwood RA, Bouras T, Gallego-Ortega D, Valdés-Mora F, Blazek K, Visvader JE, Clark SJ, Ormandy CJ. | 01/28/2012 |
| identify novel transcriptional targets of Elf5 and show that Muc4 is a direct target of Elf5, further elucidating the mechanisms through which Elf5 regulates proliferation and differentiation in the mammary gland | Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5.
Rogers RL, Van Seuningen I, Gould J, Hertzog PJ, Naylor MJ, Pritchard MA., Free PMC Article | 03/12/2011 |
| Results identify a novel Elf5-binding segment upstream of the Ccnd2 gene and demonstrate that Elf5 can transcriptionally repress Ccnd2 by directly binding to the proximal promoter region. | Genome-wide search identifies Ccnd2 as a direct transcriptional target of Elf5 in mouse mammary gland.
Escamilla-Hernandez R, Chakrabarti R, Romano RA, Smalley K, Zhu Q, Lai W, Halfon MS, Buck MJ, Sinha S., Free PMC Article | 01/1/2011 |
| propose a model for Elf5-mediated alveolar development, in which Elf5 regulates the expression of key mediators of the PrlR/Jak2/Stat5 signaling pathway | Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5.
Choi YS, Chakrabarti R, Escamilla-Hernandez R, Sinha S. | 01/21/2010 |
| KRF is a novel transcription factor that is restricted to nuclear extracts isolated from keratinocytes and that binds to unique DNA sequences, which do not resemble any known consensus binding motif for transcription factors.[KRF] | Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor.
Tummala R, Sinha S. | 01/21/2010 |
| analysis reveals previously undiscovered expression site for Elf5 in the differentiated cells of the inner root sheath of hair follicle | Generation and analysis of Elf5-LacZ mouse: unique and dynamic expression of Elf5 (ESE-2) in the inner root sheath of cycling hair follicles.
Choi YS, Cheng J, Segre J, Sinha S. | 01/21/2010 |
| Epigenetic restriction of embryonic cell lineage by methylation of Elf5 is reported. | Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.
Ng RK, Dean W, Dawson C, Lucifero D, Madeja Z, Reik W, Hemberger M., Free PMC Article | 01/21/2010 |
| These results suggest that precise levels of ELF5 regulate the specification and differentiation of epithelial cells in the lung. | Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation.
Metzger DE, Stahlman MT, Shannon JM., Free PMC Article | 01/21/2010 |
| Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development. | The Ets transcription factor Elf5 specifies mammary alveolar cell fate.
Oakes SR, Naylor MJ, Asselin-Labat ML, Blazek KD, Gardiner-Garden M, Hilton HN, Kazlauskas M, Pritchard MA, Chodosh LA, Pfeffer PL, Lindeman GJ, Visvader JE, Ormandy CJ., Free PMC Article | 01/21/2010 |
| Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning. | Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.
Donnison M, Beaton A, Davey HW, Broadhurst R, L'Huillier P, Pfeffer PL. | 01/21/2010 |
| Elf5 is essential for developmental processes in the embryo and in the mammary gland during pregnancy | Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation.
Zhou J, Chehab R, Tkalcevic J, Naylor MJ, Harris J, Wilson TJ, Tsao S, Tellis I, Zavarsek S, Xu D, Lapinskas EJ, Visvader J, Lindeman GJ, Thomas R, Ormandy CJ, Hertzog PJ, Kola I, Pritchard MA., Free PMC Article | 01/21/2010 |
| Elf5 is an FGF-sensitive transcription factor in the lung with a dynamic pattern of expression, and FGF regulation of Elf5 by means of FGFR2b occurs through the PI3-Kinase/Akt pathway. | Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Metzger DE, Xu Y, Shannon JM. | 01/21/2010 |