| Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5. | Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM(2.5).
Liu Q, Yang Y, Wu M, Wang M, Yang P, Zheng J, Du Z, Pang Y, Bao L, Niu Y, Zhang R. | 02/9/2024 |
| The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. | The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
Li TZ, Bai CY, Wu B, Zhang CY, SIRIGULENG, Wang WT, Shi TW, Zhou J., Free PMC Article | 07/10/2023 |
| Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. | Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
Liu N, He J, Fan D, Gu Y, Wang J, Li H, Zhu X, Du Y, Tian Y, Liu B, Fan Z., Free PMC Article | 08/20/2022 |
| Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression. | Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression.
Li Y, Pan Y, Gao L, Lu G, Zhang J, Xie X, Tong Z, Li B, Li G, Li W. | 02/24/2018 |
| Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling. | Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition.
Li TZ, Kim SM, Hur W, Choi JE, Kim JH, Hong SW, Lee EB, Lee JH, Yoon SK., Free PMC Article | 08/5/2017 |
| Elk3 has distinct roles in maintaining retinal artery integrity. | Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.
Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A., Free PMC Article | 05/30/2015 |
| coexpression of KLF4 led to repression of Elk-3 promoter activity | Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.
Tsoyi K, Geldart AM, Christou H, Liu X, Chung SW, Perrella MA., Free PMC Article | 03/21/2015 |
| ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density. | Cell density-dependent nuclear accumulation of ELK3 is involved in suppression of PAI-1 expression.
Tanaka S, Nakao K, Sekimoto T, Oka M, Yoneda Y. | 11/2/2013 |
| Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1. | Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
Costello P, Nicolas R, Willoughby J, Wasylyk B, Nordheim A, Treisman R. | 08/16/2010 |
| the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles | Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.
Wasylyk C, Zheng H, Castell C, Debussche L, Multon MC, Wasylyk B. | 01/21/2010 |
| Elk-3 is a strong repressor of NOS2 promoter activity and mRNA levels, and endogenous expression of Elk-3 inversely correlates with NOS2 | Elk-3 is a transcriptional repressor of nitric-oxide synthase 2.
Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA. | 01/21/2010 |
| Data show that hypoxia regulates Net differently from the other ternary complex factors and that Net plays a role in the hypoxic response in vivo in mice and in cells. | The ternary complex factor net is downregulated by hypoxia and regulates hypoxia-responsive genes.
Gross C, Buchwalter G, Dubois-Pot H, Cler E, Zheng H, Wasylyk B., Free PMC Article | 01/21/2010 |
| CTP:phosphocholine cytidylyltransferase (CT) messenger RNA(mRNA) increased at S-M phase corresponding to an increase of Ets-1 protein mRNA and decrease of Net protein mRNA indicating that Net is an important endogenous repressor for CTalpha transcription | Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha.
Sugimoto H, Okamura K, Sugimoto S, Satou M, Hattori T, Vance DE, Izumi T. | 01/21/2010 |
| A regulator of angiogenesis that can switch to an activator following induction by pro-angiogenic molecules. | The transcription factor Net regulates the angiogenic switch.
Zheng H, Wasylyk C, Ayadi A, Abecassis J, Schalken JA, Rogatsch H, Wernert N, Maira SM, Multon MC, Wasylyk B., Free PMC Article | 01/21/2010 |
| Elk-3 serves as an important repressor of heme oxygenase 1 (HO-1) gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of inflammatory stimuli | Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages.
Chung SW, Chen YH, Yet SF, Layne MD, Perrella MA. | 01/21/2010 |
| Net is a negative regulator of PAI-1 expression and is thereby involved in cell migration. | The ternary complex factor Net regulates cell migration through inhibition of PAI-1 expression.
Buchwalter G, Gross C, Wasylyk B., Free PMC Article | 01/21/2010 |