| Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain. | Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.
Valverde A, Dunys J, Lorivel T, Debayle D, Gay AS, Lacas-Gervais S, Roques BP, Chami M, Checler F., Free PMC Article | 02/19/2022 |
| Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys. | Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Marahrens B, Schulze A, Wysocki J, Lin MH, Ye M, Kanwar YS, Bader M, Velez JCQ, Miner JH, Batlle D. | 08/21/2021 |
| de-regulation of both PITX2 and ENPEP could contribute to an increased risk of atrial fibrillation in carriers of disease-associated variants. | Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP.
Aguirre LA, Alonso ME, Badía-Careaga C, Rollán I, Arias C, Fernández-Miñán A, López-Jiménez E, Aránega A, Gómez-Skarmeta JL, Franco D, Manzanares M., Free PMC Article | 09/26/2015 |
| Demonstrate a novel role of APA in ANG-(1-7) metabolism and suggest that the upregulation of APA, which occurs after myocardial infarction, may deprive the heart of cardioprotective ANG-(1-7). | Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction.
Alghamri MS, Morris M, Meszaros JG, Elased KM, Grobe N., Free PMC Article | 05/31/2014 |
| Ischemia-induced angiogenesis is impaired in APA-KO mice partly through decreased HIF-1alpha stability by proteasomal degradation and subsequent suppression of HIF-1alpha-driven target protein expression such as growth factors. | Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1α.
Kubota R, Numaguchi Y, Ishii M, Niwa M, Okumura K, Naruse K, Murohara T. | 01/1/2011 |
| Results demonstrate a key role of Thr-348 in substrate specificity of aminopeptidase A for N-terminal acidic amino acids by insuring the optimal positioning of the substrate during catalysis. | Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity.
Claperon C, Banegas-Font I, Iturrioz X, Rozenfeld R, Maigret B, Llorens-Cortes C., Free PMC Article | 01/21/2010 |
| aminopeptidase A has a role in angiotensin II conversion to angiotensin III and in water but not alcohol consumption | Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.
Faber F, Gembardt F, Sun X, Mizutani S, Siems WE, Walther T, Faber F, Gembardt F, Sun X, Mizutani S, Siems WE, Walther T. | 01/21/2010 |
| Replacement of active site residue glutamate-215 of aminopeptidase A with aspartate or alanine leads to a strong decrease in the rate of hydrolysis of the synthetic substrate alpha-L-glutamyl-beta-naphthylamide. | Contribution of molecular modeling and site-directed mutagenesis to the identification of a new residue, glutamate 215, involved in the exopeptidase specificity of aminopeptidase A.
Rozenfeld R, Iturrioz X, Okada M, Maigret B, Llorens-Cortes C. | 01/21/2010 |
| the C-terminal domain of aminopeptidase A acts as an intramolecular chaperone | The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase.
Rozenfeld R, Muller L, El Messari S, Llorens-Cortes C. | 01/21/2010 |
| dietary fatty acids affect activity in moue testis | Dietary fatty acid composition affects aminopeptidase activities in the testes of mice.
Arechaga G, Prieto I, Segarra AB, Alba F, Ruiz-Larrea MB, Ruiz-Sanz JI, de Gasparo M, Ramirez M. | 01/21/2010 |
| Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.Elevated central concentrations of the vasopressor octapeptide angiotensin (Ang) II increase the water intake in mammals. | Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.
Faber F, Gembardt F, Sun X, Mizutani S, Siems WE, Walther T, Faber F, Gembardt F, Sun X, Mizutani S, Siems WE, Walther T. | 06/13/2007 |