| Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease. | Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease.
Zakaria MF, Sonoda S, Kato H, Ma L, Uehara N, Kyumoto-Nakamura Y, Sharifa MM, Yu L, Dai L, Yamauchi-Tomoda E, Aijima R, Yamaza H, Nishimura F, Yamaza T., Free PMC Article | 03/22/2024 |
| Hemolysis-driven IFNalpha production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease. | Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease.
Han Y, Gao C, Liu Y, Zhang H, Wang S, Zhao H, Bao W, Guo X, Vinchi F, Lobo C, Shi P, Mendelson A, Luchsinger L, Zhong H, Yazdanbakhsh K, An X., | 03/15/2024 |
| Erythropoietin Receptor (EPOR) Signaling in the Osteoclast Lineage Contributes to EPO-Induced Bone Loss in Mice. | Erythropoietin Receptor (EPOR) Signaling in the Osteoclast Lineage Contributes to EPO-Induced Bone Loss in Mice.
Awida Z, Hiram-Bab S, Bachar A, Saed H, Zyc D, Gorodov A, Ben-Califa N, Omari S, Omar J, Younis L, Iden JA, Graniewitz Visacovsky L, Gluzman I, Liron T, Raphael-Mizrahi B, Kolomansky A, Rauner M, Wielockx B, Gabet Y, Neumann D., Free PMC Article | 10/22/2022 |
| Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes. | Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.
Shmukler BE, Rivera A, Nishimura K, Hsu A, Wohlgemuth JG, Dlott JS, Michael Snyder L, Brugnara C, Alper SL., Free PMC Article | 04/23/2022 |
| Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury. | Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury.
Zhang W, Wang Y, Li C, Xu Y, Wang X, Wu D, Gao Z, Qian H, You Z, Zhang Z, He B, Wang G., Free PMC Article | 02/19/2022 |
| The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise. | The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise.
Nijholt KT, Meems LMG, Ruifrok WPT, Maass AH, Yurista SR, Pavez-Giani MG, Mahmoud B, Wolters AHG, van Veldhuisen DJ, van Gilst WH, Silljé HHW, de Boer RA, Westenbrink BD., Free PMC Article | 02/5/2022 |
| EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. | EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis.
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Maxwell Scalf S, Eastman AE, Chen JJ, Zhu LJ, Heuberger JAAC, Guo S, Koury MJ, Nordsborg NB, Socolovsky M., Free PMC Article | 01/15/2022 |
| EpoR-tdTomato-Cre mice enable identification of EpoR expression in subsets of tissue macrophages and hematopoietic cells. | EpoR-tdTomato-Cre mice enable identification of EpoR expression in subsets of tissue macrophages and hematopoietic cells.
Zhang H, Wang S, Liu D, Gao C, Han Y, Guo X, Qu X, Li W, Zhang S, Geng J, Zhang L, Mendelson A, Yazdanbakhsh K, Chen L, An X., Free PMC Article | 12/25/2021 |
| Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis. | Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis.
Suresh S, Lee J, Noguchi CT., Free PMC Article | 03/27/2021 |
| Obligatory role of Schwann cell-specific erythropoietin receptors in erythropoietin-induced functional recovery and neurogenic muscle atrophy after nerve injury. | Obligatory role of Schwann cell-specific erythropoietin receptors in erythropoietin-induced functional recovery and neurogenic muscle atrophy after nerve injury.
Talukder MAH, Lee JI, Hegarty JP, Gurjar AA, O'Brien M, Karuman Z, Wandling GD, Govindappa PK, Elfar JC. | 03/20/2021 |
| Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation. | Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation.
Chen Y, Xiang J, Qian F, Diwakar BT, Ruan B, Hao S, Prabhu KS, Paulson RF., Free PMC Article | 02/27/2021 |
| Erythropoietin regulates metabolic response in mice via receptor expression in adipose tissue, brain, and bone. | Erythropoietin regulates metabolic response in mice via receptor expression in adipose tissue, brain, and bone.
Noguchi CT., Free PMC Article | 01/16/2021 |
| Downregulation of microRNA-135b promotes atherosclerotic plaque stabilization in atherosclerotic mice by upregulating erythropoietin receptor. | Downregulation of microRNA-135b promotes atherosclerotic plaque stabilization in atherosclerotic mice by upregulating erythropoietin receptor.
Wu BW, Liu Y, Wu MS, Meng YH, Lu M, Guo JD, Zhou YH. | 10/24/2020 |
| The findings support the idea that after retinovascular loss and repair, there is a repatterning of neurons within the retina to maintain connectivity of rod photoreceptors through rod bipolar cell ectopic neurites that extend into the outer nuclear layer and limit the loss of the b-wave, and that normal EPOR signaling is important in these processes. | Erythropoietin Receptor Signaling Supports Retinal Function after Vascular Injury.
Bretz CA, Simmons AB, Kunz E, Ramshekar A, Kennedy C, Cardenas I, Hartnett ME., Free PMC Article | 05/23/2020 |
| EPO/EpoR signaling in the kidney plays a critical role in acute kidney injury development, recovery, and progression to chronic kidney disease by acting on two main renal structures: renal tubules and peritubular capillaries. | Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.
Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC., Free PMC Article | 04/27/2019 |
| Scribble deficiency reduces surface expression of Epo receptor but selectively retains survival signaling via Akt. | Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
Khalil S, Delehanty L, Grado S, Holy M, White Z 3rd, Freeman K, Kurita R, Nakamura Y, Bullock G, Goldfarb A., Free PMC Article | 03/30/2019 |
| CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK. | Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.
Funakoshi-Tago M, Moriwaki T, Ueda F, Tamura H, Kasahara T, Tago K. | 12/2/2017 |
| these results have revealed that phosphorylation of Tyr-343, Tyr-460, and Tyr-464 in EpoR underlies JAK2 V617F mutant-induced tumorigenesis. | Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.
Ueda F, Tago K, Tamura H, Funakoshi-Tago M., Free PMC Article | 06/3/2017 |
| A solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising the transmembrane domain and the juxtamembrane regions reconstituted in dodecylphosphocholine (DPC) micelles. | Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles.
Li Q, Wong YL, Yueqi Lee M, Li Y, Kang C., Free PMC Article | 09/17/2016 |
| loss of function results in defective macrophage clearance of apoptotic cells in vivo | Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance.
Luo B, Gan W, Liu Z, Shen Z, Wang J, Shi R, Liu Y, Liu Y, Jiang M, Zhang Z, Wu Y. | 07/2/2016 |
| These data indicate that EpoR signaling is associated with cardiac remodeling following chronic iron deficiency. | Cardiac remodeling in response to chronic iron deficiency: role of the erythropoietin receptor.
Naito Y, Sawada H, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Mano T, Tsujino T, Masuyama T. | 03/12/2016 |
| We propose that the CID-dependent dimerization system combined with the EpoR intracellular domain and the Gata1 gene regulatory region generates a novel peroral strategy for the treatment of anemia. | In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain.
Suzuki N, Mukai HY, Yamamoto M., Free PMC Article | 02/13/2016 |
| transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles | Structural insight into the transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles.
Li Q, Wong YL, Huang Q, Kang C., Free PMC Article | 07/25/2015 |
| EpoR and its activity are downstream effectors of Klotho enabling it to function as a cytoprotective protein against oxidative injury. | The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection.
Hu MC, Shi M, Cho HJ, Zhang J, Pavlenco A, Liu S, Sidhu S, Huang LJ, Moe OW., Free PMC Article | 10/4/2014 |
| Expression of EPOR in rod photoreceptors, Muller cells, and amacrine, horizontal, and ganglion cells of the peripheral retina is not required for the maturation, function, and survival of these cells in aging tissue. | The erythropoietin receptor is not required for the development, function, and aging of rods and cells in the retinal periphery.
Caprara C, Britschgi C, Samardzija M, Grimm C., Free PMC Article | 10/4/2014 |