| Chlamydia repurposes the actin-binding protein EPS8 to disassemble epithelial tight junctions and promote infection. | Chlamydia repurposes the actin-binding protein EPS8 to disassemble epithelial tight junctions and promote infection.
Dolat L, Carpenter VK, Chen YS, Suzuki M, Smith EP, Kuddar O, Valdivia RH., Free PMC Article | 12/24/2022 |
| EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. | EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages.
Chuang JP, Kao CY, Lee JC, Ling P, Maa MC, Leu TH. | 03/20/2021 |
| Scrutinized the motility of Hnrnpab(-/-) cells and confirmed that the decreases in both cell motility and Eps8 are restored by ectopically coexpressing both alternatively spliced Hnrnpab isoforms, therefore these variants are surprisingly nonredundant for cell motility. | Hnrnpab regulates neural cell motility through transcription of Eps8.
Lampasona AA, Czaplinski K., Free PMC Article | 04/13/2019 |
| Absence of Eps8 produces a weaker phenotype in vestibular hair cells compared to cochlear inner hair cells, since it affects the hair bundle morphology but not the basolateral membrane currents. This difference is likely to explain the absence of obvious vestibular dysfunction in Eps8 knockout mice. | Distinct roles of Eps8 in the maturation of cochlear and vestibular hair cells.
Tavazzani E, Spaiardi P, Zampini V, Contini D, Manca M, Russo G, Prigioni I, Marcotti W, Masetto S. | 07/22/2017 |
| Results implicate N-methyl-d-aspartate receptor hyperfunction in the cognitive deficits observed in Epidermal growth factor receptor substrate 8 (Eps8) knockout mice and demonstrate a novel role for Eps8 in regulating hippocampal long-term synaptic plasticity and cognitive function. | Conditional deletion of Eps8 reduces hippocampal synaptic plasticity and impairs cognitive function.
Wang YT, Huang CC, Lin YS, Huang WF, Yang CY, Lee CC, Yeh CM, Hsu KS. | 07/15/2017 |
| These findings demonstrate a novel role for Wnt-Dvl1 signalling through Eps8 in the regulation of axonal remodeling. | Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8.
Stamatakou E, Hoyos-Flight M, Salinas PC., Free PMC Article | 05/21/2016 |
| It shows that EPS8, a signaling adapter regulating actin dynamics, is a novel partner of VE-cadherin and is able to modulate YAP activity. | The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.
Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E., Free PMC Article | 05/7/2016 |
| The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells. | The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
Olt J, Mburu P, Johnson SL, Parker A, Kuhn S, Bowl M, Marcotti W, Brown SD., Free PMC Article | 10/4/2014 |
| These results reveal a previously unknown cell type-specific expression pattern of endogenous Eps8 protein in the mouse hippocampus. | Cell type-specific expression of Eps8 in the mouse hippocampus.
Huang CC, Lin YS, Lee CC, Hsu KS., Free PMC Article | 08/30/2014 |
| the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects. | Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.
Menna E, Zambetti S, Morini R, Donzelli A, Disanza A, Calvigioni D, Braida D, Nicolini C, Orlando M, Fossati G, Cristina Regondi M, Pattini L, Frassoni C, Francolini M, Scita G, Sala M, Fahnestock M, Matteoli M., Free PMC Article | 08/31/2013 |
| identified Eps8 as a unique actin capping protein specifically required for Dendritic cell migration | The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration.
Frittoli E, Matteoli G, Palamidessi A, Mazzini E, Maddaluno L, Disanza A, Yang C, Svitkina T, Rescigno M, Scita G., Free PMC Article | 11/19/2011 |
| epidermal growth factor receptor pathway substrate 8 is critical in coordinating the development and functionality of mammalian auditory hair cells | Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.
Zampini V, Rüttiger L, Johnson SL, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N, Di Fiore PP, Knipper M, Masetto S, Marcotti W., Free PMC Article | 09/3/2011 |
| critical role for JNK2 and EPS8 in receptor tyrosine kinase signaling and trafficking to convey distinctly different effects on cell migration. | c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8).
Mitra S, Lee JS, Cantrell M, Van den Berg CL., Free PMC Article | 07/16/2011 |
| It was concluded that MyoXVa, whirlin, and Eps8 are integral components of the stereocilia tip complex, where Eps8 is a central actin-regulatory element for elongation of the stereocilia actin core. | Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.
Manor U, Disanza A, Grati M, Andrade L, Lin H, Di Fiore PP, Scita G, Kachar B., Free PMC Article | 06/25/2011 |
| Eps8 has a role in preventing intestinal defects and improved metabolic status in mice | Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N., Free PMC Article | 01/15/2011 |
| IRSp53, through its interaction with Eps8, not only affects cell migration but also dictates cellular growth in cancer cells. | The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation.
Liu PS, Jong TH, Maa MC, Leu TH. | 08/2/2010 |
| Expression of eps 8 and tgfbeta 1i4 (signal molecules of epidermal growth factor [EGF] or transforming growth factor-beta [TGF-beta]) showed upregulation. TGF-beta and EGF signal pathways are indicated in O. viverrini-driven cell proliferation. | Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory/secretory product.
Thuwajit C, Thuwajit P, Uchida K, Daorueang D, Kaewkes S, Wongkham S, Miwa M., Free PMC Article | 01/21/2010 |
| multifaceted role for this complex in actin dynamics, possibly through the participation in alternative larger complexes. | Eps8 controls actin-based motility by capping the barbed ends of actin filaments.
Disanza A, Carlier MF, Stradal TE, Didry D, Frittoli E, Confalonieri S, Croce A, Wehland J, Di Fiore PP, Scita G. | 01/21/2010 |
| Eps8 plays multiple roles in modulating actin filament organization, possibly through its interaction with distinct sets of actin regulatory complexes | Regulation of actin cytoskeleton architecture by Eps8 and Abi1.
Roffers-Agarwal J, Xanthos JB, Miller JR., Free PMC Article | 01/21/2010 |
| Results report that mice lacking Eps8, a regulator of actin dynamics, are resistant to some acute intoxicating effects of ethanol and show increased ethanol consumption. | Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.
Offenhäuser N, Castelletti D, Mapelli L, Soppo BE, Regondi MC, Rossi P, D'Angelo E, Frassoni C, Amadeo A, Tocchetti A, Pozzi B, Disanza A, Guarnieri D, Betsholtz C, Scita G, Heberlein U, Di Fiore PP. | 01/21/2010 |
| Eps8 is recruited into a multimolecular signaling complex by Abi1 | Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.
Innocenti M, Frittoli E, Ponzanelli I, Falck JR, Brachmann SM, Di Fiore PP, Scita G., Free PMC Article | 01/21/2010 |
| results highlight a critical role for p97(Eps8) in trichostatin A-exerted growth inhibition of v-Src-transformed cells | Participation of p97Eps8 in Src-mediated transformation.
Leu TH, Yeh HH, Huang CC, Chuang YC, Su SL, Maa MC. | 01/21/2010 |