| This cardioprotective effect was potentially achieved via up-regulating p-AKT and SLC8A3. | Protective effects of echinacoside against anoxia/reperfusion injury in H9c2 cells via up-regulating p-AKT and SLC8A3.
Chen M, Wang X, Hu B, Zhou J, Wang X, Wei W, Zhou H. | 10/13/2018 |
| Data show a general mechanism for regulatory coupling associated with Ca2+ interactions with regulatory CBD domains of NCX1, NCX2, and NCX3 isoforms and their splice variants, where the dynamic effects of alternative splicing on conformational dynamics of the two-domain regulatory tandem (CBD12) control the contribution of a given isoform/splice variant to dynamic handling of cytosolic Ca2+ oscillations in many cell type. | Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.
Giladi M, Lee SY, Ariely Y, Teldan Y, Granit R, Strulovich R, Haitin Y, Chung KY, Khananshvili D., Free PMC Article | 09/8/2018 |
| analyze the equilibrium and kinetic properties of Ca(2+) binding to purified preparations of CBD1, CBD2, and CBD12 from NCX2 and from NCX3 splice variants | Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.
Tal I, Kozlovsky T, Brisker D, Giladi M, Khananshvili D. | 02/25/2017 |
| There is a significant reduction in NCX3 expression in rats with febrile convulsions. | Na (+) /Ca (2+) Exchanger 3 is Downregulated in the Hippocampus and Cerebrocortex of Rats with Hyperthermia-induced Convulsion.
Sun D, Xiao JH, Bai Y, Chen MS, Hu JS, Wu GF, Mao B, Wu SH, Hu Y., Free PMC Article | 12/17/2016 |
| Ischemic preconditioning induced neuroprotection may occur through the modulation of calcium homeostasis in the endoplasmic reticulum and mitochondria through NO/PI3K/Akt-mediated NCX1 and NCX3 upregulation. | Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection.
Sisalli MJ, Secondo A, Esposito A, Valsecchi V, Savoia C, Di Renzo GF, Annunziato L, Scorziello A., Free PMC Article | 09/5/2015 |
| This study demonstrated that the change in NCX3 in the cell body was associated with a decrease in NCX3 protein in the ganglia, an increase in the peripheral nerve (sciatic) yet no change in the central root. | Trafficking of Na+/Ca2+ exchanger to the site of persistent inflammation in nociceptive afferents.
Scheff NN, Gold MS., Free PMC Article | 08/22/2015 |
| Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain. | Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.
Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A, Hanger DP, Noble W., Free PMC Article | 11/22/2014 |
| This study showed that normobaric hyperoxia changes the patterns of NCXs expression in the brain; up-regulates the expression of NCX3 in the in the spinal cord cord, penumbra and subcortex. | Effects of preconditioning with normobaric hyperoxia on Na⁺/Ca²⁺ exchanger in the rat brain.
Mohammadi E, Bigdeli MR. | 09/28/2013 |
| NCX3 in reverse mode was found to be another influx route for increasing [Ca2+]i, which might be involved in interstitial cells of Cajal-like cell excitability. | Reverse mode of the sodium/calcium exchanger subtype 3 in interstitial cells of Cajal from rat bladder.
Zhong X, Deng J, He P, You N, Wang Q, Song B, Li L. | 09/21/2013 |
| NCX isoforms (NCX1, NCX2, and NCX3) were expressed in primary cultured rat trigeminal ganglion neurons. | Sodium-calcium exchangers in rat trigeminal ganglion neurons.
Kuroda H, Sobhan U, Sato M, Tsumura M, Ichinohe T, Tazaki M, Shibukawa Y., Free PMC Article | 07/20/2013 |
| High levels of NCX3 overexpression increase neuronal survival following hypoxia-ischemia and improve neuronal calcium management. | High level over-expression of different NCX isoforms in HEK293 cell lines and primary neuronal cultures is protective following oxygen glucose deprivation.
Cross JL, Boulos S, Shepherd KL, Craig AJ, Lee S, Bakker AJ, Knuckey NW, Meloni BP. | 03/30/2013 |
| calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation. | Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.
Boscia F, D'Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Sokolow S, Herchuelz A, Annunziato L., Free PMC Article | 07/7/2012 |
| NCX3/Slc8a3, a Na(+)/Ca(2+) membrane exchanger, is highly expressed in astrocytes, both in vitro and in vivo, in response to glutamate-induced excitotoxicity. | Microarray analysis of rat hippocampus exposed to excitotoxicity: reversal Na(+)/Ca(2+) exchanger NCX3 is overexpressed in glial cells.
Ortuño-Sahagún D, Rivera-Cervantes MC, Gudiño-Cabrera G, Junyent F, Verdaguer E, Auladell C, Pallàs M, Camins A, Beas-Zárate C. | 05/19/2012 |
| NCX3 silencing, induced by intracerebroventricular infusion of small interfering RNA (siRNA), partially reverted postconditioning-induced neuroprotection | The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning.
Pignataro G, Esposito E, Cuomo O, Sirabella R, Boscia F, Guida N, Di Renzo G, Annunziato L., Free PMC Article | 02/5/2011 |
| Taken together, our results show that NCX subtype protein expression is sensitive to cerebral ischemia, and indicates that changes in NCX activity may be playing an important role in calcium maintenance and neuronal outcome following ischemia. | Na+/Ca2+ exchanger subtype (NCX1, NCX2, NCX3) protein expression in the rat hippocampus following 3 min and 8 min durations of global cerebral ischemia.
Bojarski C, Meloni BP, Moore SR, Majda BT, Knuckey NW. | 01/21/2010 |
| Slc8a3 constitutes a novel additional target for the prosurvival action of Akt/protein kinase B pathway. | The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway.
Formisano L, Saggese M, Secondo A, Sirabella R, Vito P, Valsecchi V, Molinaro P, Di Renzo G, Annunziato L. | 01/21/2010 |
| NCX3 protein is proposed as a distress signal able to modulate intraneuronal homeostasis of sodium and divalent calcium ions whenever neurons undergo severe anoxia. | Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage.
Molinaro P, Cuomo O, Pignataro G, Boscia F, Sirabella R, Pannaccione A, Secondo A, Scorziello A, Adornetto A, Gala R, Viggiano D, Sokolow S, Herchuelz A, Schurmans S, Di Renzo G, Annunziato L., Free PMC Article | 01/21/2010 |
| Proteolytic inactivation of NCX-driven neuronal Ca2+ extrusion is responsible for the delayed excitotoxic Ca2+ deregulation and neuronal death. | Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity.
Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera P. | 01/21/2010 |
| plasma membrane Na+/Ca2+ exchangers have inhibitory interactions with the 14-3-3 proteins | Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.
Pulina MV, Rizzuto R, Brini M, Carafoli E. | 01/21/2010 |
| NCX3 mRNAs were detected in the hippocampus, thalamus, amygdala, and cerebellum. The NCX3 protein was found in the specific subregions of the hippocampus, the ventral striatum, and in the cerebellar molecular layer. | Differential expression of the Na+-Ca2+ exchanger transcripts and proteins in rat brain regions.
Papa M, Canitano A, Boscia F, Castaldo P, Sellitti S, Porzig H, Taglialatela M, Annunziato L. | 01/21/2010 |
| Brain ischemia regulates gene expression levels of Na+/Ca2+ exchanger isoform NCX3, especially in cerebral cortex. | Altered gene expression of Na+/Ca2+ exchanger isoforms NCX1, NCX2 and NCX3 in chronic ischemic rat brain.
Lu J, Tong XY, Wang XL. | 01/21/2010 |
| The results of this study suggest that in the neuroprotective effect exerted by NCX during ischemic injury, the major role is prevalently exerted by NCX1 and NCX3 gene products. | Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia.
Pignataro G, Gala R, Cuomo O, Tortiglione A, Giaccio L, Castaldo P, Sirabella R, Matrone C, Canitano A, Amoroso S, Di Renzo G, Annunziato L. | 01/21/2010 |
| gene expression regulation in developing rat brain | Sodium-calcium exchanger NCX1, NCX2, and NCX3 transcripts in developing rat brain.
Polumuri SK, Ruknudin A, McCarthy MM, Perrot-Sinal TS, Schulze DH. | 01/21/2010 |
| Expression is depressed in heart failure. | Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system.
Shao Q, Ren B, Elimban V, Tappia PS, Takeda N, Dhalla NS. | 01/21/2010 |
| the pattern of NCX1, NCX2, and NCX3 transcripts in the ischemic core, periinfarct area, as well as in nonischemic brain regions, after 6 and 24 h of permanent middle cerebral artery occlusion | Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.
Boscia F, Gala R, Pignataro G, de Bartolomeis A, Cicale M, Ambesi-Impiombato A, Di Renzo G, Annunziato L. | 01/21/2010 |