| STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3. | STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3.
Deng L, Cao C, Cai Z, Wang Z, Leng B, Chen Z, Kong F, Zhou Z, He J, Nie X, Bian JS. | 10/9/2024 |
| Protease activated receptor-4: ready to be part of the antithrombosis spectrum. | Protease activated receptor-4: ready to be part of the antithrombosis spectrum.
Andrianova I, Kowalczyk M, Denorme F. | 08/4/2024 |
| A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity. | A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity.
Han X, Knauss EA, Fuente M, Li W, Conlon RA, LePage DF, Jiang W, Renna SA, McKenzie SE, Nieman MT. | 06/7/2024 |
| MicroRNA-26a alleviates tubulointerstitial fibrosis in diabetic kidney disease by targeting PAR4. | MicroRNA-26a alleviates tubulointerstitial fibrosis in diabetic kidney disease by targeting PAR4.
Qu G, Li X, Jin R, Guan D, Ji J, Li S, Shi H, Tong P, Gan W, Zhang A., Free PMC Article | 02/9/2024 |
| Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury. | Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury.
Erreger K, Cao S, Pan Y, Jiang M, Zhang MZ, Harris RC, Hamm HE., | 01/29/2024 |
| Lumbosacral spinal proteomic changes during PAR4-induced persistent bladder pain. | Lumbosacral spinal proteomic changes during PAR4-induced persistent bladder pain.
Ye S, Agalave NM, Ma F, D Mahmood DF, Al-Grety A, Khoonsari PE, Svensson CI, Kultima K, Vera PL., | 12/21/2023 |
| PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice. | PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice.
Lee SK, Malik RA, Zhou J, Wang W, Gross PL, Weitz JI, Ramachandran R, Trigatti BL., Free PMC Article | 10/30/2023 |
| The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. | The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.
Denorme F, Armstrong ND, Stoller ML, Portier I, Tugolukova EA, Tanner RM, Montenont E, Bhatlekar S, Cody M, Rustad JL, Ajanel A, Tolley ND, Murray DC, Boyle JL, Nieman MT, McKenzie SE, Yost CC, Lange LA, Cushman M, Irvin MR, Bray PF, Campbell RA., Free PMC Article | 09/19/2023 |
| Platelets mediate acute hepatic microcirculatory injury in a protease-activated-receptor-4-dependent manner after extended liver resection. | Platelets mediate acute hepatic microcirculatory injury in a protease-activated-receptor-4-dependent manner after extended liver resection.
Zhang Y, Huber P, Praetner M, Zöllner A, Holdt L, Khandoga A, Lerchenberger M. | 03/16/2023 |
| Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice. | Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice.
Renna SA, Michael JV, Kong X, Ma L, Ma P, Nieman MT, Edelstein LC, McKenzie SE. | 04/30/2022 |
| Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling. | Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling.
Cao D, Strainic MG, Counihan D, Sridar S, An F, Hussain W, Schmaier AH, Nieman M, Medof ME., Free PMC Article | 03/5/2022 |
| Protease-activated receptor 4 plays a role in lipopolysaccharide-induced inflammatory mechanisms in murine macrophages. | Protease-activated receptor 4 plays a role in lipopolysaccharide-induced inflammatory mechanisms in murine macrophages.
Barra A, Freitas KM, Marconato DG, Faria-Pinto P, Lopes MTP, Klein A. | 11/27/2021 |
| Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture After Myocardial Infarction. | Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture After Myocardial Infarction.
Kolpakov MA, Guo X, Rafiq K, Vlasenko L, Hooshdaran B, Seqqat R, Wang T, Fan X, Tilley DG, Kostyak JC, Kunapuli SP, Houser SR, Sabri A., Free PMC Article | 09/4/2021 |
| Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart. | Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart.
Fender AC, Kleeschulte S, Stolte S, Leineweber K, Kamler M, Bode J, Li N, Dobrev D., Free PMC Article | 10/31/2020 |
| PAR4 protects mice from viral infections of the heart and lung | Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection.
Tatsumi K, Schmedes CM, Houston ER, Butler E, Mackman N, Antoniak S., Free PMC Article | 06/13/2020 |
| Endogenous H2S generated by CBS or CSE caused referred hyperalgesia mediated through MIF in mice with PAR4-induced bladder pain, without causing bladder injury or altering micturition behavior. | Endogenous H(2)S sensitizes PAR4-induced bladder pain.
Wang W, Bo Q, Du J, Yu X, Zhu K, Cui J, Zhao H, Wang Y, Shi B, Zhu Y. | 09/14/2019 |
| Par-4 activation and binding to TERT are key steps required for inducing the apoptosis of islet beta cells under high-glucose/fatty acid conditions in type 2 diabetes. | TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes.
Liu C, QiNan W, XiaoTian L, MengLiu Y, XiaGuang G, WeiLing L, ZiWen L, Ling Z, GangYi Y, Bing C., Free PMC Article | 12/22/2018 |
| these findings are the first to show that internalization of activated PAR4 is linked to proper ERK1/2 and Akt activation. | Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins.
Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J., Free PMC Article | 05/13/2017 |
| Par4 deficiency offers cardioprotection after acute ischemia reperfusion injury. | Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury.
Kolpakov MA, Rafiq K, Guo X, Hooshdaran B, Wang T, Vlasenko L, Bashkirova YV, Zhang X, Chen X, Iftikhar S, Libonati JR, Kunapuli SP, Sabri A., Free PMC Article | 10/22/2016 |
| Bladder PAR4 stimulation affected urothelial HMGB1 release. | Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1.
Kouzoukas DE, Ma F, Meyer-Siegler KL, Westlund KN, Hunt DE, Vera PL., Free PMC Article | 08/6/2016 |
| Thrombin cleavage of platelet PAR4 promotes leukocyte recruitment to sites of vascular injury. | Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.
Kaplan ZS, Zarpellon A, Alwis I, Yuan Y, McFadyen J, Ghasemzadeh M, Schoenwaelder SM, Ruggeri ZM, Jackson SP. | 05/14/2016 |
| Bladder PAR activation elicits urothelial MIF release and urothelial MIF receptor signaling at least partly through CXCR4 to result in abdominal hypersensitivity without overt bladder inflammation | Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.
Kouzoukas DE, Meyer-Siegler KL, Ma F, Westlund KN, Hunt DE, Vera PL., Free PMC Article | 04/2/2016 |
| PAR4 blockade impairs neutrophil migration in vivo, suggesting that PAR4 plays an important role in the regulation of inflammation | Blockade of proteinase-activated receptor 4 inhibits neutrophil recruitment in experimental inflammation in mice.
Gomides LF, Lima OC, Matos NA, Freitas KM, Francischi JN, Tavares JC, Klein A. | 06/27/2015 |
| PAR-4 appears to play a hitherto unsuspected role in diabetic vasculopathy. | Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus.
Pavic G, Grandoch M, Dangwal S, Jobi K, Rauch BH, Doller A, Oberhuber A, Akhyari P, Schrör K, Fischer JW, Fender AC. | 03/7/2015 |
| mPAR4 contributes to antibacterial defence during murine pneumococcal pneumonia | Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice.
de Stoppelaar SF, Van't Veer C, van den Boogaard FE, Nieuwland R, Hoogendijk AJ, de Boer OJ, Roelofs JJ, van der Poll T. | 04/12/2014 |