| Sulfiredoxin-1 promotes the growth of hepatocellular carcinoma by inhibiting TFEB-mediated autophagy and lysosome biogenesis. | Sulfiredoxin-1 promotes the growth of hepatocellular carcinoma by inhibiting TFEB-mediated autophagy and lysosome biogenesis.
Rao Q, Guo M, Sun J, Yang B, Cao X, Xia J. | 08/13/2024 |
| Unraveling the role of sulfiredoxin-1 in early-onset preeclampsia: A key player in trophoblast ferroptosis. | Unraveling the role of sulfiredoxin-1 in early-onset preeclampsia: A key player in trophoblast ferroptosis.
Wei J, Qiu D, Yang X, Wang J, Shi M, Sun L, Lu X, Wang C, Liu H, Li R. | 07/25/2024 |
| Antioxidative stress protein SRXN1 can be used as a radiotherapy prognostic marker for prostate cancer. | Antioxidative stress protein SRXN1 can be used as a radiotherapy prognostic marker for prostate cancer.
Wang X, Yu J, Wen H, Yan J, Peng K, Zhou H., Free PMC Article | 09/22/2023 |
| CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1. | CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1.
Luo J, Tian Z, Zhou Y, Xiao Z, Park SY, Sun H, Zhuang T, Wang Y, Li P, Zhao X., Free PMC Article | 07/17/2023 |
| Sulfiredoxin-1 is a promising novel prognostic biomarker for hepatocellular carcinoma. | Sulfiredoxin-1 is a promising novel prognostic biomarker for hepatocellular carcinoma.
Rao QW, Zhang SL, Guo MZ, Yuan FF, Sun JL, Qi F, Wang LS, Yang BW, Xia JL., Free PMC Article | 07/24/2021 |
| SRXN1 stimulates hepatocellular carcinoma tumorigenesis and metastasis through modulating ROS/p65/BTG2 signalling. | SRXN1 stimulates hepatocellular carcinoma tumorigenesis and metastasis through modulating ROS/p65/BTG2 signalling.
Lv X, Yu H, Zhang Q, Huang Q, Hong X, Yu T, Lan H, Mei C, Zhang W, Luo H, Pang P, Shan H., Free PMC Article | 05/15/2021 |
| Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer. | Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer.
Barquilha CN, Santos NJ, Monção CCD, Barbosa IC, Lima FO, Justulin LA, Pértega-Gomes N, Felisbino SL., Free PMC Article | 01/9/2021 |
| Sulfiredoxin exhibits an increased association with TXNDC5, facilitating the retention of Srx in the endoplasmic reticulum. The cellular levels of Srx and TXNDC5 may be useful as biomarkers to predict the survival of individuals with lung cancer. | The redox regulator sulfiredoxin forms a complex with thioredoxin domain-containing 5 protein in response to ER stress in lung cancer cells.
Chawsheen HA, Jiang H, Ying Q, Ding N, Thapa P, Wei Q., Free PMC Article | 02/22/2020 |
| Srx expression, MDA levels, and ROS levels in BGC823 cells were markedly inhibited upon treatment with diallyl trisulfide (DATS), a major constituent of garlic oil with proven anticancer effects. These results suggest that Srx may be an oxidative stress marker. Antioxidation may account for the anticancer potential of garlic. | Increased Sulfiredoxin Expression in Gastric Cancer Cells May Be a Molecular Target of the Anticancer Component Diallyl Trisulfide.
Wang J, Si L, Wang G, Bai Z, Li W., Free PMC Article | 06/22/2019 |
| NRF2, DJ1 and SRNX1 are commonly expressed in diffusely infiltrating astrocytomas and they can be used in predicting patient prognosis. | NRF2, DJ1 and SNRX1 and their prognostic impact in astrocytic gliomas.
Haapasalo J, Nordfors K, Granberg KJ, Kivioja T, Nykter M, Haapasalo H, Soini Y. | 12/1/2018 |
| Study identify a role for Srxn1 as a denitrosylase for neuronal Prx2. Finding points to the NO/Srxn1 pair in a previously unrecognized redox cycle that modulates Prx2 peroxidase activity. | Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons.
Sunico CR, Sultan A, Nakamura T, Dolatabadi N, Parker J, Shan B, Han X, Yates JR 3rd, Masliah E, Ambasudhan R, Nakanishi N, Lipton SA., Free PMC Article | 03/31/2018 |
| Wnt/beta-catenin pathway was stimulated by sulfiredoxin in tumor cell line, with activation of CD44-its target genes-resulting in the promotion of invasion and migration in cervical cancer cell lines. | Sulfiredoxin May Promote Cervical Cancer Metastasis via Wnt/β-Catenin Signaling Pathway.
Lan K, Zhao Y, Fan Y, Ma B, Yang S, Liu Q, Linghu H, Wang H., Free PMC Article | 01/27/2018 |
| This review will highlight the cumulative effects of sulfiredoxin in various systemic disorders with a strong emphasis on its target activity and the factors influencing its expression in such conditions. | Role of sulfiredoxin in systemic diseases influenced by oxidative stress.
Ramesh A, Varghese SS, Doraiswamy J, Malaiappan S., Free PMC Article | 01/13/2018 |
| The up-regulated expression of Srx was significantly associated with lymph node metastasis, infiltration of vessels, and the depth of cancer invasion. | [Highly expressed sulfiredoxin and β-catenin are associated with malignancy of cervical squamous cell carcinoma].
Lan K, Chen X, Liu Q, Fan Y, Zhao Y, Wang H. | 09/16/2017 |
| The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance | SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome.
Turolo S, Edefonti A, Lepore M, Ghio L, Cuzzoni E, Decorti G, Pasini A, Materassi M, Malaventura C, Pugliese F, Montini G. | 08/12/2017 |
| rs6053666 of SRXN1 is associated with cerebrovascular disease in a Finnish cohort | Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study.
Kunnas T, Määttä K, Nikkari ST., Free PMC Article | 06/10/2017 |
| Increased expression of Srx protects peroxiredoxins against hyperoxidation in the early stage of hyperglycaemia. | Sulfiredoxin involved in the protection of peroxiredoxins against hyperoxidation in the early hyperglycaemia.
Shi S, Guo Y, Lou Y, Li Q, Cai X, Zhong X, Li H. | 05/27/2017 |
| We silenced Srx by short hairpin RNA in HeLa and SiHa cells. Diminished Srx expression upregulated E-cadherin expression. The cell invasion and migration activity in the ShSrx group were obviously decreased in HeLa and SiHa cells. | Sulfiredoxin may promote metastasis and invasion of cervical squamous cell carcinoma by epithelial-mesenchymal transition.
Chen X, Lan K, Liu Q, Yang X, Wang H. | 04/8/2017 |
| Study shows that Srx plays a critical oncogenic role to promote cell invasion and metastasis, which is at least partially due to its stimulation of the MAPK pathway through EGFR deacetylation. | Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling.
Jiang H, Wu L, Chen J, Mishra M, Chawsheen HA, Zhu H, Wei Q., Free PMC Article | 10/8/2016 |
| This review will summarize the molecular basis of differences in the affinity of Srx for individual Prx and the role of individual component of the Srx-Prx system in tumor progression and metastasis. | The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development.
Mishra M, Jiang H, Wu L, Chawsheen HA, Wei Q., Free PMC Article | 10/10/2015 |
| Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-beta. | Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β.
Jana M, Mondal S, Gonzalez FJ, Pahan K., Free PMC Article | 01/5/2013 |
| NRF2 and SRXN1 genetic polymorphisms are associated with breast cancer risk and survival | Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer.
Hartikainen JM, Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y. | 01/5/2013 |
| SRX forms a complex with S100A4 (and has stronger affinity for S-glutathionylated S100A4), regulates its activity, and mediates redox regulation of the interaction of S100A4 with nonmuscle myosin heavy chain II-A. | Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility.
Bowers RR, Manevich Y, Townsend DM, Tew KD., Free PMC Article | 12/22/2012 |
| Smokers and ex-smokers had significantly more sulfiredoxin expression in their tumors and in patients receiving cytostatic drugs or radiation therapy, sulfiredoxin expression predicted a poor prognosis. | Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer.
Merikallio H, Pääkkö P, Kinnula VL, Harju T, Soini Y. | 05/12/2012 |
| Srx functions as a novel component to maintain the balance between H2O2 production and elimination | Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2.
Baek JY, Han SH, Sung SH, Lee HE, Kim YM, Noh YH, Bae SH, Rhee SG, Chang TS., Free PMC Article | 05/12/2012 |