| IgE-ICs are noninflammatory through reduced engagement by FcepsilonRI but increased targeting of the CD23 pathway. | CD23 provides a noninflammatory pathway for IgE-allergen complexes.
Engeroff P, Caviezel F, Mueller D, Thoms F, Bachmann MF, Vogel M. | 08/1/2020 |
| Human and murine P2X7 activation induces the rapid shedding of CD23 from B cells, with a potential role for ADAM10 in this process. | Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.
Pupovac A, Geraghty NJ, Watson D, Sluyter R. | 09/5/2015 |
| CD23 was shown to be sorted in an ADAM10-dependent manner into exosomes. | CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes.
Mathews JA, Gibb DR, Chen BH, Scherle P, Conrad DH., Free PMC Article | 01/1/2011 |
| B cells captured IgE by direct binding to the low-affinity IgE receptor, CD23. | Murine B cells regulate serum IgE levels in a CD23-dependent manner.
Cheng LE, Wang ZE, Locksley RM., Free PMC Article | 11/13/2010 |
| CD23 is an important regulatory factor for IgE production | 129/SvJ mice have mutated CD23 and hyper IgE.
Ford JW, Sturgill JL, Conrad DH., Free PMC Article | 01/21/2010 |
| BAFF does not preferentially induce the expression of CD23 or CD21. | Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23.
Debnath I, Roundy KM, Weis JJ, Weis JH., Free PMC Article | 01/21/2010 |
| After exposure for 10 consecutive days to nebulized ovalbumin challenge, mice with disrupted Fc epsilon RI alpha subunit show low response to electrical field stimulation, less airway inflammation and goblet cell hyperplasia, and lower IL-13 in the lung. | Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant.
Taube C, Wei X, Swasey CH, Joetham A, Zarini S, Lively T, Takeda K, Loader J, Miyahara N, Kodama T, Shultz LD, Donaldson DD, Hamelmann EH, Dakhama A, Gelfand EW. | 01/21/2010 |
| mechanism by which endogenous B cell activity in vivo is regulated by norepinephrine involves stimulation of the beta2-adrenergic receptor on the B cell alone to increase the level of IgE produced in a p38 MAPK- and soluble CD23-dependent manner | The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner.
Pongratz G, McAlees JW, Conrad DH, Erbe RS, Haas KM, Sanders VM. | 01/21/2010 |
| A positive internalization signal for IgE transepithelial transport is localized in the cytoplasmic region shared by all CD23 splice forms. This positive signal is negatively regulated by the intracellular CD23b-specific exon. | Intracellular trafficking of CD23: differential regulation in humans and mice by both extracellular and intracellular exons.
Montagnac G, Mollà-Herman A, Bouchet J, Yu LC, Conrad DH, Perdue MH, Benmerah A. | 01/21/2010 |
| Overall, the data provide a direct demonstration for CD23's role in regulating IgE production in vivo and suggest that therapies aimed at stabilizing cell surface CD23 would be beneficial in controlling allergic disease. | In vivo murine CD23 destabilization enhances CD23 shedding and IgE synthesis.
Ford JW, Kilmon MA, Haas KM, Shelburne AE, Chan-Li Y, Conrad DH. | 01/21/2010 |
| the functions of CD23 splice forms, b and bDelta5, in the apical to basolateral transcytosis of IgE/allergen complexes were investigated | Differential role for CD23 splice forms in apical to basolateral transcytosis of IgE/allergen complexes.
Montagnac G, Yu LC, Bevilacqua C, Heyman M, Conrad DH, Perdue MH, Benmerah A. | 01/21/2010 |