| FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-kappaB pathway. | FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway.
Hu Z, Dai J, Xu T, Chen H, Shen G, Zhou J, Ma H, Wang Y, Jin L., Free PMC Article | 03/4/2024 |
| Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis. | Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis.
Tsuchiya Y, Seki T, Kobayashi K, Komazawa-Sakon S, Shichino S, Nishina T, Fukuhara K, Ikejima K, Nagai H, Igarashi Y, Ueha S, Oikawa A, Tsurusaki S, Yamazaki S, Nishiyama C, Mikami T, Yagita H, Okumura K, Kido T, Miyajima A, Matsushima K, Imasaka M, Araki K, Imamura T, Ohmuraya M, Tanaka M, Nakano H., Free PMC Article | 11/6/2023 |
| FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice. | FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Tong G, Chen Y, Chen X, Fan J, Zhu K, Hu Z, Li S, Zhu J, Feng J, Wu Z, Hu Z, Zhou B, Jin L, Chen H, Shen J, Cong W, Li X., Free PMC Article | 10/10/2023 |
| TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. | TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
Feng J, Han X, Yuan Y, Cho CK, Janečková E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, Jing J, Zhang M, Xu J, Ho TV, Chai Y., Free PMC Article | 12/31/2022 |
| Tissue-specific analysis of Fgf18 gene function in palate development. | Tissue-specific analysis of Fgf18 gene function in palate development.
Yue M, Lan Y, Liu H, Wu Z, Imamura T, Jiang R., Free PMC Article | 03/5/2022 |
| Fibroblast growth factor 18 alleviates hyperoxia-induced lung injury in mice by adjusting oxidative stress and inflammation. | Fibroblast growth factor 18 alleviates hyperoxia-induced lung injury in mice by adjusting oxidative stress and inflammation.
Li XG, Song X, Wang JY, Sun CH, Li ZQ, Meng LL, Chi SH. | 09/18/2021 |
| The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. | The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Boylan M, Anderson MJ, Ornitz DM, Lewandoski M., Free PMC Article | 12/26/2020 |
| Using a novel Fgf18:CreERT2 allele to lineage trace alveolar myofibroblast, it is demonstrated that most alveolar myofibroblast are developmentally cleared during alveologenesis. | Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis.
Hagan AS, Zhang B, Ornitz DM., Free PMC Article | 07/4/2020 |
| Study found that Fgf18 mRNA was one of the spinal motor neurons (SMNs)-specific FGFs in adult mice. Fgf18 mRNA was expressed in the spinal cord, and to a lesser extent in the diaphragm, in mouse embryos. In C2C12 myotubes, FGF18 enhanced AChR clustering. These data propose that FGF18 plays a pivotal role in AChR clustering and NMJ formation in mouse embryogenesis. | Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.
Ito K, Ohkawara B, Yagi H, Nakashima H, Tsushima M, Ota K, Konishi H, Masuda A, Imagama S, Kiyama H, Ishiguro N, Ohno K., Free PMC Article | 12/1/2018 |
| Elevation of FGF signaling, mainly due to increased Fgf18 expression upon inactivation of Evc2 in the perichondrium, critically contributes to the pathogenesis of limb dwarfism. The limb dwarfism phenotype is partially rescued by inactivation of one allele of Fgf18 in the Evc2 mutant mice | Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.
Zhang H, Kamiya N, Tsuji T, Takeda H, Scott G, Rajderkar S, Ray MK, Mochida Y, Allen B, Lefebvre V, Hung IH, Ornitz DM, Kunieda T, Mishina Y., Free PMC Article | 05/13/2017 |
| Loss of alleles of Fgf9 and Fgf18 also affect the expression of genes encoding other key intrinsic skeletal regulators, including IHH, PTHLH (PTHrP), and RUNX2, revealing potential direct, indirect, and compensatory mechanisms to coordinate chondrogenesis and osteogenesis. | A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development.
Hung IH, Schoenwolf GC, Lewandoski M, Ornitz DM., Free PMC Article | 08/6/2016 |
| retinoic acid is produced by pulmonary endothelial cells and regulates pulmonary angiogenesis and elastin synthesis by induction of VEGF-A and fibroblast growth factor (FGF)-18, respectively | VEGF and endothelium-derived retinoic acid regulate lung vascular and alveolar development.
Yun EJ, Lorizio W, Seedorf G, Abman SH, Vu TH., Free PMC Article | 07/30/2016 |
| novel Shh-Foxf-Fgf18-Shh circuit in the palate development molecular network, in which Foxf1 and Foxf2 regulate palatal shelf growth downstream of Shh signaling, at least in part, by repressing Fgf18 expression | A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.
Xu J, Liu H, Lan Y, Aronow BJ, Kalinichenko VV, Jiang R., Free PMC Article | 05/14/2016 |
| post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1 | FGF signalling regulates bone growth through autophagy.
Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C. | 01/16/2016 |
| Phlpp1 deficiency increases Akt2 activity, which diminishes FoxO1 levels and induces Fgf18 expression to stimulate chondrocyte proliferation. | Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.
Bradley EW, Carpio LR, Newton AC, Westendorf JJ., Free PMC Article | 10/3/2015 |
| These results suggest that FGF18 accelerates osteogenesis by upregulation of Bmp2 as well as maintenance or upregulation of Fgfr1, -2 and -3 expression in osteoblasts. | FGF18 accelerates osteoblast differentiation by upregulating Bmp2 expression.
Nagayama T, Okuhara S, Ota MS, Tachikawa N, Kasugai S, Iseki S. | 02/15/2014 |
| Fgf-10 and Fgf-18 are expressed specifically within ventral tanycyte subpopulations. | α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.
Robins SC, Stewart I, McNay DE, Taylor V, Giachino C, Goetz M, Ninkovic J, Briancon N, Maratos-Flier E, Flier JS, Kokoeva MV, Placzek M. | 01/4/2014 |
| Foxp1 regulates the quiescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression. | Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18.
Leishman E, Howard JM, Garcia GE, Miao Q, Ku AT, Dekker JD, Tucker H, Nguyen H., Free PMC Article | 11/16/2013 |
| These findings therefore argue for an involvement of FGF18 in the control of various developmental events during the alveolar stage. | Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development.
Franco-Montoya ML, Boucherat O, Thibault C, Chailley-Heu B, Incitti R, Delacourt C, Bourbon JR., Free PMC Article | 05/5/2012 |
| Fgf-18 is an important mediator of bone regeneration, which is required during later stages of bone regeneration. | Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair.
Behr B, Sorkin M, Manu A, Lehnhardt M, Longaker MT, Quarto N., Free PMC Article | 11/26/2011 |
| FGF18 is upregulated during osteoblast differentiation induced by dexamethasone in murine mesenchymal stem cells. | Autocrine fibroblast growth factor 18 mediates dexamethasone-induced osteogenic differentiation of murine mesenchymal stem cells.
Hamidouche Z, Fromigué O, Nuber U, Vaudin P, Pages JC, Ebert R, Jakob F, Miraoui H, Marie PJ. | 06/28/2010 |
| Regulation of Hmgn1 and Fgf18 at the digit-interdigit junction suggests retinoic acid controls tissue remodeling as well as apoptosis. | Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction.
Zhao X, Brade T, Cunningham TJ, Duester G., Free PMC Article | 05/10/2010 |
| Data revealed interaction between Glg1 and Fgf18 both genetically and physically and reveals a novel regulatory mechanism for Fgf18 signaling involving Glg1 and Dlk. | A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk).
Miyaoka Y, Tanaka M, Imamura T, Takada S, Miyajima A. | 02/1/2010 |
| FGF18 provided both directional and proliferative cues to chondrocytes in the developing upper respiratory tract. | Fibroblast growth factor 18 gives growth and directional cues to airway cartilage.
Elluru RG, Thompson F, Reece A., Free PMC Article | 01/21/2010 |
| Data indicate that FGF18 and FGFR3 are involved, possibly as partners, in the control of intestinal precursor cell proliferation. | FGFR3 contributes to intestinal crypt cell growth arrest.
Arnaud-Dabernat S, Yadav D, Sarvetnick N. | 01/21/2010 |