| Identification of follicle-stimulating hormone-responsive genes in Sertoli cells during early postnatal mouse testis development. | Identification of follicle-stimulating hormone-responsive genes in Sertoli cells during early postnatal mouse testis development.
Wang H, Liu Z, Larsen M, Hastings R, Gunewardena S, Kumar TR. | 06/18/2023 |
| Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells. | Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.
Soejima Y, Iwata N, Nakayama N, Hirata S, Nakano Y, Yamamoto K, Suyama A, Oguni K, Nada T, Fujisawa S, Otsuka F., Free PMC Article | 10/1/2022 |
| Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure. | Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure.
Jie H, Jinxiang W, Ye L, Jing Z, Iangqing ZX, Jinxiu H, Zian L, Xinghua P. | 07/16/2022 |
| A speech planning network for interactive language use. | A speech planning network for interactive language use.
Castellucci GA, Kovach CK, Howard MA 3rd, Greenlee JDW, Long MA., Free PMC Article | 03/12/2022 |
| FSH directly regulates chondrocyte dedifferentiation and cartilage development. | FSH directly regulates chondrocyte dedifferentiation and cartilage development.
Wang Y, Zhang M, Huan Z, Shao S, Zhang X, Kong D, Xu J. | 07/24/2021 |
| Human Follicle-Stimulating Hormone ss Subunit Expression Depends on FOXL2 and SMAD4. | Human Follicle-Stimulating Hormone ß Subunit Expression Depends on FOXL2 and SMAD4.
Ongaro L, Schang G, Zhou Z, Kumar TR, Treier M, Deng CX, Boehm U, Bernard DJ., Free PMC Article | 01/9/2021 |
| Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B. | Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B.
Schang G, Ongaro L, Schultz H, Wang Y, Zhou X, Brûlé E, Boehm U, Lee SJ, Bernard DJ., Free PMC Article | 12/19/2020 |
| FSH signaling is involved in affective disorders. | FSH signaling is involved in affective disorders.
Bi WK, Luan SS, Wang J, Wu SS, Jin XC, Fu YL, Gao L, Zhao JJ, He Z. | 12/12/2020 |
| Our current findings show that elevated FSH had minimal disruption of either embryo developmental capacity or uterine function when examined in isolation, and the subfertility of TgFSH female mice was not caused by altered oocyte aneuploidy or quality. | Reproductive failure in mice expressing transgenic follicle-stimulating hormone is not caused by loss of oocyte quality.
Upton DH, Walters KA, McTavish KJ, Holt J, Handelsman DJ, Allan CM. | 08/3/2019 |
| FSH enhances CRTC2-mediated gluconeogenesis dependent on AMPK Ser485 phosphorylation via GRK2 in the liver, suggesting an essential role of FSH in the pathogenesis of fasting hyperglycaemia | Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.
Qi X, Guo Y, Song Y, Yu C, Zhao L, Fang L, Kong D, Zhao J, Gao L. | 02/2/2019 |
| FSH induces autophagy via upregulation of HIF-1A in mouse granulosa cells. | Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells.
Zhou J, Yao W, Li C, Wu W, Li Q, Liu H., Free PMC Article | 04/28/2018 |
| the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated. | Evaluation of in vivo bioactivities of recombinant hypo- (FSH(21/18)) and fully- (FSH(24)) glycosylated human FSH glycoforms in Fshb null mice.
Wang H, May J, Butnev V, Shuai B, May JV, Bousfield GR, Kumar TR., Free PMC Article | 11/11/2017 |
| These mice showed an increase in FSH levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice. | Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state.
Allen SJ, Garcia-Galiano D, Borges BC, Burger LL, Boehm U, Elias CF., Free PMC Article | 07/1/2017 |
| GnRH stimulated the secretion of the VGF-derived peptide NERP1. NERP1 caused a concentration-dependent decrease in Fshb gene induction. | Characterization of Gonadotrope Secretoproteome Identifies Neurosecretory Protein VGF-derived Peptide Suppression of Follicle-stimulating Hormone Gene Expression.
Choi SG, Wang Q, Jia J, Chikina M, Pincas H, Dolios G, Sasaki K, Wang R, Minamino N, Salton SR, Sealfon SC., Free PMC Article | 05/20/2017 |
| the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression. | GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER.
Thompson IR, Ciccone NA, Zhou Q, Xu S, Khogeer A, Carroll RS, Kaiser UB., Free PMC Article | 12/17/2016 |
| Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule-5 (Icam5) in females but only decreased expression of Icam5 in males. | Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A.
Eckstrum KS, Weis KE, Baur NG, Yoshihara Y, Raetzman LT., Free PMC Article | 08/20/2016 |
| GnRH stimulation of Fshb expression is dependent on miR-132/212 and involves a SIRT1-FOXO1 pathway. | Rapid communication: A microRNA-132/212 pathway mediates GnRH activation of FSH expression.
Lannes J, L'Hôte D, Garrel G, Laverrière JN, Cohen-Tannoudji J, Quérat B., Free PMC Article | 03/5/2016 |
| results suggest that FOXO1 binding to the proximal Fshb promoter as well as FOXO1 interaction with SMAD3/4 proteins may result in decreased activin induction of Fshb in gonadotropes | Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes.
Park CH, Skarra DV, Rivera AJ, Arriola DJ, Thackray VG., Free PMC Article | 01/16/2016 |
| SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. | Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.
Miyano Y, Tahara S, Sakata I, Sakai T, Abe H, Kimura S, Kurotani R., Free PMC Article | 11/22/2014 |
| Data suggest that the BMP2-like Activin A/BMP2 chimera AB215 regulates follicle stimulating hormone beta (FSHbeta) induction in LbetaT2 gonadotroph cells due to its ability to block activin A signaling. | Regulation of FSHβ induction in LβT2 cells by BMP2 and an Activin A/BMP2 chimera, AB215.
Jung JW, Ahn C, Shim SY, Gray PC, Kwiatkowski W, Choe S. | 11/22/2014 |
| Two regions of the proximal Fshb promoter (-50/-41 and -30/-21) appear to be necessary for FOXO1 suppression of GnRH-induced Fshb transcription. | Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes.
Skarra DV, Arriola DJ, Benson CA, Thackray VG., Free PMC Article | 06/21/2014 |
| Data suggest BMP2 (bone morphogenetic protein 2) stimulates SMAD2/3 signaling in gonadotrophs via Bmpr1a (bone morphogenetic protein receptor type 1A); such signaling via SMAD3 appears to be necessary for up-regulation of Fshb transcription. | Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis.
Wang Y, Ho CC, Bang E, Rejon CA, Libasci V, Pertchenko P, Hébert TE, Bernard DJ. | 06/21/2014 |
| The activin A signals via SMAD proteins, but not TAK1 or p38, to regulate murine and ovine Fshb transcription in gonadotrope-like cells. | Activin A induction of murine and ovine follicle-stimulating hormone β transcription is SMAD-dependent and TAK1 (MAP3K7)/p38 MAPK-independent in gonadotrope-like cells.
Wang Y, Bernard DJ. | 02/1/2014 |
| The insulin/IGF signaling pathway is required for FSH-mediated Sertoli cell proliferation. | An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
Pitetti JL, Calvel P, Zimmermann C, Conne B, Papaioannou MD, Aubry F, Cederroth CR, Urner F, Fumel B, Crausaz M, Docquier M, Herrera PL, Pralong F, Germond M, Guillou F, Jégou B, Nef S., Free PMC Article | 01/18/2014 |
| FOXL2 is required for FSH synthesis in vivo. | Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice.
Tran S, Zhou X, Lafleur C, Calderon MJ, Ellsworth BS, Kimmins S, Boehm U, Treier M, Boerboom D, Bernard DJ., Free PMC Article | 10/19/2013 |