| The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei. | The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei.
Rashpa R, Klages N, Schvartz D, Pasquarello C, Brochet M., Free PMC Article | 03/29/2023 |
| CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma. | CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma.
Zhang X, Zhang T, Han X, Qiu Z, Cheng J, Gao X, Gou X. | 01/22/2022 |
| CAC1 plays an important role in the occurrence and promotion of antineoplastic drug resistance in colorectal cancer. CAC1 knockdown resulted in decreased P-glycoprotein and MRP-1 protein expression. | CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer.
Chen N, Kong Y, Wu Y, Gao Q, Fu J, Sun X, Geng Q., Free PMC Article | 03/7/2020 |
| These data suggest that CACUL1 is a novel regulator that negatively controls p53 activity through the regulation of PML SUMOylation. | CACUL1/CAC1 attenuates p53 activity through PML post-translational modification.
Fukuda T, Kigoshi-Tansho Y, Naganuma T, Kazaana A, Okajima T, Tsuruta F, Chiba T. | 06/3/2017 |
| Suggest that CACUL1 impairs LSD1-mediated activation of AR, thereby implicating it as a potential antitumor target in prostate cancer cells. | CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells.
Choi H, Lee SH, Um SJ, Kim EJ. | 02/18/2017 |
| silencing CACUL1 resulted in the same effects of miR-106a* overexpression in esophageal carcinoma cells, including suppressed esophageal carcinoma cell proliferation and blocked G1/S transition through CDK2 pathway by inhibiting cell cycle regulators. | miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1).
Ma HL, Wen XP, Zhang XZ, Wang XL, Zhao DL, Che SM, Dang CX. | 10/1/2016 |
| H. pylori-triggered CACUL1 production occurred in an activating protein 1-dependent manner and regulated matrix metalloproteinase 9 and Slug expression to affect the invasion and metastasis of tumor cells. | Helicobacter pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1.
Kong Y, Ma LQ, Bai PS, Da R, Sun H, Qi XG, Ma JQ, Zhao RM, Chen NZ, Nan KJ. | 08/30/2014 |
| CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways. | CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells.
Chen TJ, Gao F, Yang T, Thakur A, Ren H, Li Y, Zhang S, Wang T, Chen MW. | 10/19/2013 |
| High CAC1 expression is associated with cisplatin resistance in gastric cancer. | CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line.
Zheng Q, Zhao LY, Kong Y, Nan KJ, Yao Y, Liao ZJ., Free PMC Article | 08/31/2013 |
| miR-199a-5p can regulate CAC1 and function as a tumor suppressor in colorectal cancer. | The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer.
Kong Y, Bai PS, Sun H, Nan KJ, Chen NZ, Qi XG. | 04/27/2013 |
| CAC1 is an important factor for the protection of cells against amyloid beta toxicity and oxidative stress in Alzheimer's disease. | Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients.
Kong Y, Bai PS, Sun H, Nan KJ. | 03/30/2013 |
| CAC1 is a novel corepressor of RARalpha that cooperates with HDACs and is involved in the regulation of RA-induced cellular differentiation. | CAC1 negatively regulates RARα activity through cooperation with HDAC.
Moon M, Um SJ, Kim EJ. | 03/2/2013 |
| Data suggest that CAC1, in association with LSD1 (lysine-specific histone demethylase 1), functions as a corepressor of estrogen receptor alpha and may be involved in drug resistance in breast cancer. | Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1.
Kim J, Park UH, Moon M, Um SJ, Kim EJ. | 03/2/2013 |
| CAC1 is a novel cell cycle associated protein capable of promoting cell proliferation. | Identification and characterization of CAC1 as a novel CDK2-associated cullin.
Kong Y, Nan K, Yin Y. | 02/8/2010 |