| The DNA demethylation within the fut7 gene controls selectin ligand expression in mice, including the inducible topographic commitment of T cells for skin and inflamed sites. | Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.
Pink M, Ratsch BA, Mardahl M, Durek P, Polansky JK, Karl M, Baumgrass R, Wallner S, Cadenas C, Gianmoena K, Floess S, Chen W, Nordstroem K, Tierling S, Olek S, Walter J, Hamann A, Syrbe U. | 09/30/2017 |
| Cloning of an intragenic region spanning a 1kb region upstream of exon 4 into an enhancer-containing vector indeed elicited fut7 promoter activity in cd4 positive T cells. | Identification of two regulatory elements controlling Fucosyltransferase 7 transcription in murine CD4+ T cells.
Pink M, Ratsch BA, Mardahl M, Schröter MF, Engelbert D, Triebus J, Hamann A, Syrbe U. | 01/3/2015 |
| These results demonstrate that all genetic information essential for appropriate and selective expression of Fut7 in diverse cell types and in response to distinct developmental signals is contained within this comparatively small genetic region. | Defining the functional boundaries of the murine α1,3-fucosyltransferase Fut7 reveals a remarkably compact locus.
Ebel ME, Kansas GS., Free PMC Article | 06/28/2014 |
| alpha(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis. | α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.
Wang H, Morales-Levy M, Rose J, Mackey LC, Bodary P, Eitzman D, Homeister JW., Free PMC Article | 11/16/2013 |
| Functional PSGL-1 generated by basophil FT-IV/VII and its subsequent binding to L-selectin could be one of the essential steps required for initial basophil recruitment and the development of IgE-chronic allergic inflammation in mice. | α(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation.
Saeki K, Satoh T, Yokozeki H. | 11/2/2013 |
| striking differences between the requirement of FucT-VII and C2GlcNAcT-I for Ligands for E-selectin and P-selectin expression in CD4+ T cells. | Differential regulation and impact of fucosyltransferase VII and core 2 β1,6-N-acetyl-glycosaminyltransferase for generation of E-selectin and P-selectin ligands in murine CD4+ T cells.
Schroeter MF, Ratsch BA, Lehmann J, Baumgrass R, Hamann A, Syrbe U., Free PMC Article | 03/2/2013 |
| Loss of the barrier protective molecule TFF3 leads to a profound increase in susceptibility to DSS-induced colitis, and this can be abrogated by reducing Fuc-TVII-dependent leukocyte recruitment. | Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ., Free PMC Article | 07/19/2010 |
| a deficiency in Fuc-TVII, and in a more pronounced fashion, a combined deficiency in both Fuc-TIV and Fuc-TVII, leads to accelerated death following M. tuberculosis infection | Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.
Ehlers S, Schreiber T, Dunzendorfer A, Lowe JB, Hölscher C. | 01/21/2010 |
| Keratan sulfate sulfotransferase competes with FucT-VII for the same acceptor substrate and downregulates the synthesis of L-selectin ligand by inhibiting alpha1,3-fucosylation. | Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing.
Hiraoka N, Petryniak B, Kawashima H, Mitoma J, Akama TO, Fukuda MN, Lowe JB, Fukuda M. | 01/21/2010 |
| FucT-VII is an important pathophysiologic mediator of renal ischemia reperfusion injury, structural damage, and neutrophil infiltration postischemia. | Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury.
Burne MJ, Rabb H. | 01/21/2010 |
| FT-IV and FT-VII are both important contributors to selectin-dependent eosinophil recruitment to the skin and may represent therapeutic targets for treating diseases in which eosinophil recruitment contributes to pathophysiology. | Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.
Satoh T, Kanai Y, Wu MH, Yokozeki H, Kannagi R, Lowe JB, Nishioka K., Free PMC Article | 01/21/2010 |
| Efficient recruitment of activated lymphocytes to the brain in a model mimicking early inflammation during experimental allergic encephalomyelitis is controlled by FucT-VII. | Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.
Piccio L, Rossi B, Colantonio L, Grenningloh R, Gho A, Ottoboni L, Homeister JW, Scarpini E, Martinello M, Laudanna C, D'Ambrosio D, Lowe JB, Constantin G. | 01/21/2010 |