| Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury. | Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
Zhang Y, Gong X., Free PMC Article | 03/7/2024 |
| FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis. | FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis.
Yang Y, Yao M, Zeng J, Zheng D, Li Q, Ni Y, Xiao X., Free PMC Article | 09/10/2022 |
| DHF-7 Ameliorates Behavioral Disorders and White Matter Lesions by Regulating BDNF and Fyn in a Mouse Model of Schizophrenia Induced by Cuprizone and MK-801. | DHF-7 Ameliorates Behavioral Disorders and White Matter Lesions by Regulating BDNF and Fyn in a Mouse Model of Schizophrenia Induced by Cuprizone and MK-801.
Sun ZY, Ma DL, Gu LH, Chen X, Zhang L, Li L., Free PMC Article | 08/13/2022 |
| Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis. | Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis.
Menzel V, Ziegler M, Hante N, Sake JA, Santos-Martinez MJ, Ehrhardt C, Kasper M, Barth K. | 07/9/2022 |
| Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in ice. | Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in mice.
Trittmann JK, Jin Y, Liu Y, Nelin LD., Free PMC Article | 09/25/2021 |
| Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation. | Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
Taleski G, Schuhmacher D, Su H, Sontag JM, Sontag E., Free PMC Article | 08/28/2021 |
| Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase. | Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase.
Mattè A, Lupo F, Tibaldi E, Di Paolo ML, Federti E, Carpentieri A, Pucci P, Brunati AM, Cesaro L, Turrini F, Gomez Manzo S, Choi SY, Marcial Quino J, Kim DW, Pantaleo A, Xiuli A, Iatcenko I, Cappellini MD, Forni GL, De Franceschi L., Free PMC Article | 07/10/2021 |
| Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis. | Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis.
Wang S, Li X, Zhang Q, Chai X, Wang Y, Förster E, Zhu X, Zhao S. | 06/12/2021 |
| Fyn depletion ameliorates tau(P301L)-induced neuropathology. | Fyn depletion ameliorates tau(P301L)-induced neuropathology.
Liu G, Fiock KL, Levites Y, Golde TE, Hefti MM, Lee G., Free PMC Article | 06/5/2021 |
| Fyn Kinase Controls Tau Aggregation In Vivo. | Fyn Kinase Controls Tau Aggregation In Vivo.
Briner A, Götz J, Polanco JC. | 05/29/2021 |
| Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor. | Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
Higa-Nakamine S, Okitsu-Sakurayama S, Kina S, Yamamoto H. | 05/22/2021 |
| Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. | Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research.
Saminathan H, Charli A, Luo J, Panicker N, Gordon R, Hostetter JM, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A., Free PMC Article | 05/15/2021 |
| Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses. | Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses.
Comba A, Dunn PJ, Argento AE, Kadiyala P, Ventosa M, Patel P, Zamler DB, Núñez FJ, Zhao L, Castro MG, Lowenstein PR., Free PMC Article | 05/8/2021 |
| Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on calcium. | Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on calcium.
Liu G, Thangavel R, Rysted J, Kim Y, Francis MB, Adams E, Lin Z, Taugher RJ, Wemmie JA, Usachev YM, Lee G., Free PMC Article | 08/15/2020 |
| In vivo experiments using A53T and viral-alphaSyn overexpression mouse models as well as human Parkinson's disease neuropathological results further confirm the role of Fyn in NLRP3 inflammasome activation. | Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A., Free PMC Article | 04/18/2020 |
| Tau controls the nanoscale organization of Fyn in dendrites, with the pathological Tau P301L mutation potentially contributing to synaptic dysfunction by promoting aberrant Fyn nanoclustering in spines. | Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines.
Padmanabhan P, Martínez-Mármol R, Xia D, Götz J, Meunier FA., Free PMC Article | 02/29/2020 |
| Fyn(-/-) mice exhibit reduced Tyr-phosphorylation of EPO-R and decreased STAT5-activity. Fyn(-/-) mice responded poorly to stress erythropoiesis. Absence of Fyn resulted in persistent-activation of Nrf2, accumulation of nonfunctional proteins, ROS-induced over-activation of Jak2-Akt-mTOR-pathway, and repression of autophagy with perturbation of lysosomal-clearance. | Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.
Beneduce E, Matte A, De Falco L, Mbiandjeu S, Chiabrando D, Tolosano E, Federti E, Petrillo S, Mohandas N, Siciliano A, Babu W, Menon V, Ghaffari S, Iolascon A, De Franceschi L., Free PMC Article | 11/16/2019 |
| Our results suggest that Fyn-mediated regulation of the cell-cell adhesion of neuroblasts is critical for their detachment from chains in the postnatal brain | Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain.
Fujikake K, Sawada M, Hikita T, Seto Y, Kaneko N, Herranz-Pérez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, García-Verdugo JM, Hattori M, Sobue K, Sawamoto K., Free PMC Article | 10/26/2019 |
| MiR-125a-3p exerts anti-fibrotic effects in silica-induced pulmonary fibrosis by regulating Fyn/STAT3 signaling. | Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis.
Xu Q, Liu Y, Pan H, Xu T, Li Y, Yuan J, Li P, Yao W, Yan W, Ni C. | 08/17/2019 |
| We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues. | Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.
Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM., Free PMC Article | 03/11/2019 |
| Fyn has a critical role in the molecular pathways affected during the development of L-DOPA-induced dyskinesia. | The Kinase Fyn As a Novel Intermediate in L-DOPA-Induced Dyskinesia in Parkinson's Disease.
Sanz-Blasco S, Bordone MP, Damianich A, Gomez G, Bernardi MA, Isaja L, Taravini IR, Hanger DP, Avale ME, Gershanik OS, Ferrario JE. | 02/9/2019 |
| Our findings suggest a mechanism, by which a decrease in miR-125a-3p during oocyte maturation facilitates GVBD by allowing Fyn up-regulation and the resulting stabilization of the interaction between actin and A-type lamins. | Regulation of GVBD in mouse oocytes by miR-125a-3p and Fyn kinase through modulation of actin filaments.
Grossman H, Har-Paz E, Gindi N, Levi M, Miller I, Nevo N, Galiani D, Dekel N, Shalgi R., Free PMC Article | 12/22/2018 |
| Fyn and Lyn as important factors that promote Plasmacytoid dendritic cell responses. | Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses.
Dallari S, Macal M, Loureiro ME, Jo Y, Swanson L, Hesser C, Ghosh P, Zuniga EI., Free PMC Article | 11/10/2018 |
| these results suggest that Nrf2 plays a central role in the prevention of Ang II-induced cardiomyopathy, and SFN prevents Ang II-induced cardiomyopathy partially via the Akt/GSK-3beta/Fyn-mediated Nrf2 activation. | Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway.
Xin Y, Bai Y, Jiang X, Zhou S, Wang Y, Wintergerst KA, Cui T, Ji H, Tan Y, Cai L., Free PMC Article | 10/13/2018 |
| This study reported that suppression of Fyn expression in mouse cerebral cortex led to migration defects of both early-born and late-born neurons. | Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex.
Huang Y, Li G, An L, Fan Y, Cheng X, Li X, Yin Y, Cong R, Chen S, Zhao S. | 03/10/2018 |