| The GABRA6 SNP rs3219151 has been significantly associated with alcohol dependence in studies on the Taiwanese Han, Korean, Finnish and South-western Native American populations. | Association of serotonin and GABA pathway gene polymorphisms with alcohol dependence: A preliminary study.
Sahni S, Tickoo M, Gupta R, Vaswani M, Ambekar A, Grover T, Sharma A. | 05/11/2019 |
| D3R modulates GABAA receptors function in striatum: chronic blockade of D3R increases alpha6 subunit expression and induces insensitivity to the anxiolytic effect of diazepam | Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam.
Leggio GM, Torrisi SA, Castorina A, Platania CB, Impellizzeri AA, Fidilio A, Caraci F, Bucolo C, Drago F, Salomone S. | 06/11/2016 |
| This study demonstrated that Ectopic Expression of alpha6 GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. | Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
Tong X, Peng Z, Zhang N, Cetina Y, Huang CS, Wallner M, Otis TS, Houser CR., Free PMC Article | 04/23/2016 |
| results indicate that in addition to the central role of homologous gamma-aminobutyric acid (GABA) A receptor subunit alpha 6-100R/Q (alpha1-101H) residue in benzodiazepine(BZ) binding this critical BZ binding site has a major impact on BZ binding kinetics | The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.
Kontturi LS, Aalto AJ, Wallner M, Uusi-Oukari M., Free PMC Article | 11/24/2012 |
| We tested the hypothesis that homocysteine (Hcy) antagonizes the GABA(A) receptor and behaves as an excitotoxic neurotransmitter that causes blood brain barrier (BBB) permeability and vascular dementia. | GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice.
Kumar M, Tyagi N, Moshal KS, Sen U, Pushpakumar SB, Vacek T, Lominadze D, Tyagi SC., Free PMC Article | 01/21/2010 |
| These findings suggest that the higher CNS depressant level achieved by ketamine may be the result of its selective actions on alpha6beta2/3delta receptors. | Ketamine, but not phencyclidine, selectively modulates cerebellar GABA(A) receptors containing alpha6 and delta subunits.
Hevers W, Hadley SH, Lüddens H, Amin J., Free PMC Article | 01/21/2010 |
| Abnormal cerebellar P/Q-type VGCC activity results in a deficit of CGC-specific subtype(s) of GABA(A) receptors which may contribute to, or may be a consequence of the impaired cerebellar network signaling that occurs in cacna1a(tg) mice. | Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering.
Kaja S, Hann V, Payne HL, Thompson CL. | 01/21/2010 |
| some aspects of assembly, trafficking, targeting, and/or expression of extrasynaptic alpha6-containing GABA(A) receptors in cerebellar granule cells are selectively regulated by AMPA receptor-mediated signaling | GABAA alpha6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer.
Payne HL, Connelly WM, Ives JH, Lehner R, Furtmuller B, Sieghart W, Tiwari P, Lucocq JM, Lees G, Thompson CL., Free PMC Article | 01/21/2010 |
| Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling. | Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling.
Ives JH, Drewery DL, Thompson CL. | 01/21/2010 |
| ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition | Ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition.
Wisden W, Cope D, Klausberger T, Hauer B, Sinkkonen ST, Tretter V, Lujan R, Jones A, Korpi ER, Mody I, Sieghart W, Somogyi P. | 01/21/2010 |
| GABRA6 expression is regulated by NFI in cerebellar granule neurons | A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression.
Wang W, Stock RE, Gronostajski RM, Wong YW, Schachner M, Kilpatrick DL. | 01/21/2010 |