| GABAA receptor beta1 -subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep. | GABA(A) receptor β(1) -subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep.
Lie MEK, Falk-Petersen CB, Piilgaard L, Griem-Krey N, Wellendorph P, Kornum BR. | 08/21/2021 |
| In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ... | The GABA(A) Receptor β Subunit Is Required for Inhibitory Transmission.
Nguyen QA, Nicoll RA., Free PMC Article | 08/3/2019 |
| Results indicate that GABAB1a and GABAB1b isoforms differentially regulate behavioural responses to cocaine, with deletion of GABAB1a enhancing cocaine-induced locomotor activity and deletion of GABAB1b protecting from cocaine-induced sensitisation | Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.
Jacobson LH, Sweeney FF, Kaupmann K, O'Leary OF, Gassmann M, Bettler B, Cryan JF. | 09/24/2016 |
| Study of GABAB1 KO mice provides genetic evidence for a specific involvement of GABAB receptors in the regulation of the behavioral and biochemical effects induced by nicotine withdrawal in mice | Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.
Varani AP, Pedrón VT, Machado LM, Antonelli MC, Bettler B, Balerio GN. | 08/22/2015 |
| Heritable preference for ethanol results from a dominant mutation L285R; P228H also causes high ethanol consumption | Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.
Anstee QM, Knapp S, Maguire EP, Hosie AM, Thomas P, Mortensen M, Bhome R, Martinez A, Walker SE, Dixon CI, Ruparelia K, Montagnese S, Kuo YT, Herlihy A, Bell JD, Robinson I, Guerrini I, McQuillin A, Fisher EM, Ungless MA, Gurling HM, Morgan MY, Brown SD, Stephens DN, Belelli D, Lambert JJ, Smart TG, Thomas HC., Free PMC Article | 07/19/2014 |
| we conclude that is a greater contribution of beta(1) -subunit-containing GABA(A) receptors following oxygen and glucose deprivation in cerebellar Purkinje cells | Alterations in Purkinje cell GABAA receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of β1 -subunit-containing receptors.
Kelley MH, Ortiz J, Shimizu K, Grewal H, Quillinan N, Herson PS., Free PMC Article | 11/16/2013 |
| GABA(B)R1 positively regulates chondrogenesis through a mechanism relevant to the acceleration of nuclear translocation of ATF4 for Ihh expression in chondrocytes | Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.
Takahata Y, Hinoi E, Takarada T, Nakamura Y, Ogawa S, Yoneda Y., Free PMC Article | 12/22/2012 |
| This study demonistrated that Gabeb1 gene expression in mouse dorsal raphe nucleus | Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Templin JS, Bang SJ, Soiza-Reilly M, Berde CB, Commons KG., Free PMC Article | 09/15/2012 |
| The endogenous sleep pathway in the hypothalamus operates through the beta1- containing GABAAR whereas inhibition of neuronal firing (anaesthesia) by low propofol doses relies on beta3- containing GABAAR. | GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies.
Yanovsky Y, Schubring S, Fleischer W, Gisselmann G, Zhu XR, Lübbert H, Hatt H, Rudolph U, Haas HL, Sergeeva OA. | 06/23/2012 |
| beta1-containing GABA(A)Rs are expressed in the hypothalamus | Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors.
Sergeeva OA, Kletke O, Kragler A, Poppek A, Fleischer W, Schubring SR, Görg B, Haas HL, Zhu XR, Lübbert H, Gisselmann G, Hatt H., Free PMC Article | 09/20/2010 |
| Gabrb1 is involved in abnormal prion protein formation and this is independent of GABAA receptors. | GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.
Kimura T, Ishikawa K, Sakasegawa Y, Teruya K, Sata T, Schätzl H, Doh-ura K. | 05/3/2010 |
| Expression of the GABA(A) receptor beta subunit, which is required for receptor function, is reduced in the cortex, hippocampus, diencephalon and brainstem in adult male fragile X mice compared to wild-type. | Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse.
El Idrissi A, Ding XH, Scalia J, Trenkner E, Brown WT, Dobkin C. | 01/21/2010 |
| Identification of a beta subunit TM2 residue mediating proton modulation of GABA type A receptors | Identification of a beta subunit TM2 residue mediating proton modulation of GABA type A receptors.
Wilkins ME, Hosie AM, Smart TG., Free PMC Article | 01/21/2010 |