| JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth. | JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth.
Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M. | 09/24/2022 |
| Mice lacking growth-associated protein 43 develop cardiac remodeling and hypertrophy. | Mice lacking growth-associated protein 43 develop cardiac remodeling and hypertrophy.
Bevere M, Morabito C, Guarnieri S, Mariggiò MA., Free PMC Article | 05/21/2022 |
| Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates. | Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M., Free PMC Article | 01/22/2022 |
| Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse. | Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse.
Merino P, Diaz A, Torre ER, Yepes M., Free PMC Article | 09/19/2020 |
| Diabetic mice developed disorganized and debilitated retinal layers with upregulation of the gliosis marker GFAP and downregulation of the neuronal plasticity marker GAP43. | Neuroprotective effect of levetiracetam in mouse diabetic retinopathy: Effect on glucose transporter-1 and GAP43 expression.
Mohammad HMF, Sami MM, Makary S, Toraih EA, Mohamed AO, El-Ghaiesh SH. | 09/28/2019 |
| Mutation of a predicted N6-methyladenosine (m6A) site in GAP-43 mRNA eliminated its m6A modification and exempted regulation of its local translation by axonal FTO. | Dynamic m6A modification regulates local translation of mRNA in axons.
Yu J, Chen M, Huang H, Zhu J, Song H, Zhu J, Park J, Ji SJ., Free PMC Article | 07/6/2019 |
| hnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development. | hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation.
Williams KR, McAninch DS, Stefanovic S, Xing L, Allen M, Li W, Feng Y, Mihailescu MR, Bassell GJ., Free PMC Article | 10/29/2016 |
| The GASP-43 is involves in the orientation of cell division by interacting with Galphai. | The influence of GAP-43 on orientation of cell division through G proteins.
Huang R, Zhao J, Ju L, Wen Y, Xu Q. | 09/17/2016 |
| Trimethyltin decreased synaptophysin but not GAP-43 expression in the mouse hippocampus. | Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning and memory impairment.
Zhang L, Zhao Q, Chen CH, Qin QZ, Zhou Z, Yu ZP. | 02/21/2015 |
| Antiretroviral drugs may recruit the HuD-GAP43 pathway, potentially contributing to a response to the antiretroviral neuronal toxicity. | PKC-mediated HuD-GAP43 pathway activation in a mouse model of antiretroviral painful neuropathy.
Sanna MD, Quattrone A, Ghelardini C, Galeotti N. | 12/20/2014 |
| KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. | KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
Bird CW, Gardiner AS, Bolognani F, Tanner DC, Chen CY, Lin WJ, Yoo S, Twiss JL, Perrone-Bizzozero N., Free PMC Article | 11/29/2014 |
| these findings suggest that GAP-43 is dynamically involved in early postnatal and adult hippocampal neurogenesis and synaptic connectivity, possibly contributing to the GAP-43+/- behavioral phenotype. | Developmental and adult GAP-43 deficiency in mice dynamically alters hippocampal neurogenesis and mossy fiber volume.
Latchney SE, Masiulis I, Zaccaria KJ, Lagace DC, Powell CM, McCasland JS, Eisch AJ., Free PMC Article | 11/22/2014 |
| In this review, GAP-43 in vivo knockdown in olivary neurons leads to the atrophy of their climbing fibers and a reduction in the ability to sprout toward surrounding denervated Purkinje cells. | Structural plasticity of climbing fibers and the growth-associated protein GAP-43.
Grasselli G, Strata P., Free PMC Article | 05/24/2014 |
| GAP-43 is required to sustain synaptic stability and promote the initiation of axonal regrowth | In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex.
Allegra Mascaro AL, Cesare P, Sacconi L, Grasselli G, Mandolesi G, Maco B, Knott GW, Huang L, De Paola V, Strata P, Pavone FS., Free PMC Article | 09/7/2013 |
| In vitro results indicated that GAP43 is indeed expressed in both myoblasts and differentiating myotubes, and its cellular localization changes dramatically during maturation. | Growth associated protein 43 is expressed in skeletal muscle fibers and is localized in proximity of mitochondria and calcium release units.
Guarnieri S, Morabito C, Paolini C, Boncompagni S, Pilla R, Fanò-Illic G, Mariggiò MA., Free PMC Article | 07/6/2013 |
| Initial emergence of hollows in the somatosensory cortex is no different between GAP43 heterozygous mice and nonheterozygous littermate controls; however, the emergence of sides and septa is delayed by 2 days. | Emergence of layer IV barrel cytoarchitecture is delayed in somatosensory cortex of GAP-43 deficient mice following delayed development of dendritic asymmetry.
Zaccaria KJ, McCasland JS. | 06/15/2013 |
| This study demonistrated that neuronal responses to netrin-1 have been directly demonstrated to require GAP-43. | GAP-43 dependency defines distinct effects of netrin-1 on cortical and spinal neurite outgrowth and directional guidance.
Shen Y, Meiri K. | 06/1/2013 |
| Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43 | Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.
Kong E, Peng S, Chandra G, Sarkar C, Zhang Z, Bagh MB, Mukherjee AB., Free PMC Article | 06/1/2013 |
| Nos2 deficiency promotes medulloblastoma development in Ptch1(+/-) mice through retention of proliferating GCPs in the external granular layer due to reduced Gap43 expression | Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.
Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, Blond F, Delhomme N, Hahn M, Reifenberger J, Reifenberger G, Lichter P., Free PMC Article | 09/8/2012 |
| GAP-43 expression in the mucosal myenteric plexus was markedly reduced in the small intestines of Neodiplostomum seoulense-infected mice. | Depressed neuronal growth associated protein (GAP)-43 expression in the small intestines of mice experimentally infected with Neodiplostomum seoulense.
Pyo KH, Kang EY, Jung BK, Moon JH, Chai JY, Shin EH., Free PMC Article | 08/4/2012 |
| These data suggest the efficient transcription of the distal promoter of Gap43 is an important mark for the transition of P19 cells from the progenitor stage into neuronal differentiation. | The differential regulation of Gap43 gene in the neuronal differentiation of P19 cells.
Zhao JC, Zhang LX, Zhang Y, Shen YF. | 04/21/2012 |
| GAP-43 is essential both to maintain climbing fibres structure in non-traumatic condition and to promote sprouting after partial lesion of the inferior olive. | Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of the growth-associated protein GAP-43.
Grasselli G, Mandolesi G, Strata P, Cesare P., Free PMC Article | 11/5/2011 |
| The Gap43 and Pten network highlights the covariance of gene expression and forms a molecular network associated with axonal outgrowth in the adult retina. | Genetic networks in the mouse retina: growth associated protein 43 and phosphatase tensin homolog network.
Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE., Free PMC Article | 10/1/2011 |
| Results suggest that GAP-43 might link the cell membrane and spindle pole and consequently participate in controlling cleavage orientation during cell division. | Expression of GAP-43 in fibroblast cell lines influences the orientation of cell division.
Zhao J, Yao Y, Xu C, Cheng B, Xu Q. | 09/17/2011 |
| all the effects of environmental stimulation are amplified if the afferent Purkinje axons are endowed with enhanced intrinsic growth capabilities, induced by overexpression of GAP-43 | Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses.
Foscarin S, Ponchione D, Pajaj E, Leto K, Gawlak M, Wilczynski GM, Rossi F, Carulli D., Free PMC Article | 08/6/2011 |