| Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis. | Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis.
Fu J, Tang Y, Zhang Z, Tong L, Yue R, Cai L., Free PMC Article | 01/15/2022 |
| Gastrin induces nuclear export and proteasome degradation of menin in duodenal glial cells. | Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.
Sundaresan S, Meininger CA, Kang AJ, Photenhauer AL, Hayes MM, Sahoo N, Grembecka J, Cierpicki T, Ding L, Giordano TJ, Else T, Madrigal DJ, Low MJ, Campbell F, Baker AM, Xu H, Wright NA, Merchant JL., Free PMC Article | 12/9/2017 |
| PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis. | Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells.
Al Menhali A, Keeley TM, Demitrack ES, Samuelson LC., Free PMC Article | 08/12/2017 |
| Renal-selective silencing of Gast by the renal subcapsular injection of Gast siRNA in BALB/c mice decreases renal dopamine production and increases blood pressure. | Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of l-DOPA.
Jiang X, Zhang Y, Yang Y, Yang J, Asico LD, Chen W, Felder RA, Armando I, Jose PA, Yang Z., Free PMC Article | 06/24/2017 |
| Gastrin is expressed in insulin secreting cells of adult diabetic mice. | Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.
Dahan T, Ziv O, Horwitz E, Zemmour H, Lavi J, Swisa A, Leibowitz G, Ashcroft FM, In't Veld P, Glaser B, Dor Y., Free PMC Article | 06/10/2017 |
| CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF in gastric epithelial cells. | Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion.
Bhandari S, Bakke I, Kumar J, Beisvag V, Sandvik AK, Thommesen L, Varro A, Nørsett KG. | 05/13/2017 |
| increased circulating concentrations of progastrin provide a physiological advantage against systemic hypoxia in mice | Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions.
Laval M, Baldwin GS, Shulkes A, Marshall KM. | 03/21/2015 |
| Ihh signaling mediates gastrin-induced proliferation of epithelial cells in stomachs of adult mice. | Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.
Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y., Free PMC Article | 10/18/2014 |
| mouse corneal afferent sensory neurons expressed CCK and GAST, and the CCK1R receptors. | Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea.
Gonzalez-Coto AF, Alonso-Ron C, Alcalde I, Gallar J, Meana Á, Merayo-Lloves J, Belmonte C. | 05/10/2014 |
| Data indicate that epithelial Gli2 expression was sufficient to stimulate Il-1beta expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia. | Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.
Saqui-Salces M, Covés-Datson E, Veniaminova NA, Waghray M, Syu LJ, Dlugosz AA, Merchant JL., Free PMC Article | 04/6/2013 |
| gastrins play an important direct role, unrelated to their ability to stimulate acid secretion, in hematopoiesis under conditions of iron deficiency. | Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency.
Kovac S, Anderson GJ, Alexander WS, Shulkes A, Baldwin GS., Free PMC Article | 09/24/2011 |
| Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin. | Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.
Tomita H, Takaishi S, Menheniott TR, Yang X, Shibata W, Jin G, Betz KS, Kawakami K, Minamoto T, Tomasetto C, Rio MC, Lerkowit N, Varro A, Giraud AS, Wang TC., Free PMC Article | 05/14/2011 |
| Regulation of mouse gastrin gene in vivo. Mechanisms involved in transcriptional control of the gastrin gene. | In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.
Takaishi S, Shibata W, Tomita H, Jin G, Yang X, Ericksen R, Dubeykovskaya Z, Asfaha S, Quante M, Betz KS, Shulkes A, Wang TC., Free PMC Article | 03/19/2011 |
| RegI and gastrin may synergistically regulate gastric mucosal proliferation during certain pathological settings like wound healing | Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis.
Peterson AJ, Nguyen N, Okamoto H, Giraud AS, van Driel IR, Judd LM. | 04/12/2010 |
| Results suggest that RNAi targeting of gastrin could serve as an effective treatment for pancreatic cancer. | Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression.
Matters GL, Harms JF, McGovern CO, Jayakumar C, Crepin K, Smith ZP, Nelson MC, Stock H, Fenn CW, Kaiser J, Kester M, Smith JP., Free PMC Article | 01/21/2010 |
| beta-catenin and NFkappaB have roles in signaling pathways in colonic crypts of mice with progastrin | Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin.
Umar S, Sarkar S, Wang Y, Singh P., Free PMC Article | 01/21/2010 |
| Hypergastrinemia increases regeneration of intestinal epithelia following diverse forms of injury. | Gastrin increases murine intestinal crypt regeneration following injury.
Ottewell PD, Duckworth CA, Varro A, Dimaline R, Wang TC, Watson AJ, Dockray GJ, Pritchard DM. | 01/21/2010 |
| Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells. | Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells.
Pagliocca A, Hegyi P, Venglovecz V, Rackstraw SA, Khan Z, Burdyga G, Wang TC, Dimaline R, Varro A, Dockray GJ. | 01/21/2010 |
| in juvenile animals when iron demand is high, circulating gastrin concentrations may alter iron status by a CCK2R-independent mechanism. | Interrelationships between circulating gastrin and iron status in mice and humans.
Kovac S, Smith K, Anderson GJ, Burgess JR, Shulkes A, Baldwin GS., Free PMC Article | 01/21/2010 |
| Antral hyperplasia in Gas-/- mice involves amplification of mucous cell lineages due to follistatin, suggesting its role in the development of antral gastric tumors. | Induction of follistatin precedes gastric transformation in gastrin deficient mice.
Kang W, Saqui-Salces M, Zavros Y, Merchant JL., Free PMC Article | 01/21/2010 |
| Depletion of endogenous progastrin inhibits the tumorigenicity of APC-mutated colorectal cancer cells in vivo by promoting ICAT expression, thereby counteracting beta-catenin/Tcf-4 activity. | Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.
Pannequin J, Delaunay N, Buchert M, Surrel F, Bourgaux JF, Ryan J, Boireau S, Coelho J, Pélegrin A, Singh P, Shulkes A, Yim M, Baldwin GS, Pignodel C, Lambeau G, Jay P, Joubert D, Hollande F. | 01/21/2010 |
| Gastrin regulates TFF2 transcription through a GC-rich DNA-binding site and a protein kinase dependent pathway. | Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.
Tu S, Chi AL, Lim S, Cui G, Dubeykovskaya Z, Ai W, Fleming JV, Takaishi S, Wang TC. | 01/21/2010 |
| Parietal cells were found to be significantly smaller in the mutant cell preparations, suggesting that gastrin stimulation modulates parietal cell morphology. | Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice.
Hinkle KL, Bane GC, Jazayeri A, Samuelson LC. | 01/21/2010 |
| stimulates the growth of gastric pit cell precursors by inducing its own receptors. | Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptors.
Nakajima T, Konda Y, Izumi Y, Kanai M, Hayashi N, Chiba T, Takeuchi T. | 01/21/2010 |
| gastrin promoter is activated by transforming growth factor-beta/Smad and Wnt signaling pathways | The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.
Lei S, Dubeykovskiy A, Chakladar A, Wojtukiewicz L, Wang TC. | 01/21/2010 |