| Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease. | Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MJ, Marciano DK, Gordillo R, Drucker DJ, Scherer PE., | 03/11/2024 |
| Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice. | Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice.
Srivastava SP, Goodwin JE., Free PMC Article | 09/13/2023 |
| Glucagon receptor blockage inhibits beta-cell dedifferentiation through FoxO1. | Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1.
Wang K, Cui X, Li F, Xia L, Wei T, Liu J, Fu W, Yang J, Hong T, Wei R. | 01/28/2023 |
| Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice. | Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
Galsgaard KD, Elmelund E, Johansen CD, Bomholt AB, Kizilkaya HS, Ceutz F, Hunt JE, Kissow H, Winther-Sørensen M, Sørensen CM, Kruse T, Lau JF, Rosenkilde MM, Ørskov C, Christoffersen C, Holst JJ, Wewer Albrechtsen NJ., Free PMC Article | 01/14/2023 |
| Glucagon receptor signaling at white adipose tissue does not regulate lipolysis. | Glucagon receptor signaling at white adipose tissue does not regulate lipolysis.
Vasileva A, Marx T, Beaudry JL, Stern JH., Free PMC Article | 10/22/2022 |
| Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors. | Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.
Hunt JE, Yassin M, Olsen J, Hartmann B, Holst JJ, Kissow H., Free PMC Article | 02/19/2022 |
| Glucagon blockade restores functional beta-cell mass in type 1 diabetic mice and enhances function of human islets. | Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.
Wang MY, Dean ED, Quittner-Strom E, Zhu Y, Chowdhury KH, Zhang Z, Zhao S, Li N, Ye R, Lee Y, Zhang Y, Chen S, Yu X, Leonard DC, Poffenberger G, Von Deylen A, McCorkle SK, Schlegel A, Sloop KW, Efanov AM, Gimeno RE, Scherer PE, Powers AC, Unger RH, Holland WL., Free PMC Article | 08/7/2021 |
| The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1. | The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
Ji L, Wang Q, Liu M, Zhu C, Xiao Y, Han J, Fang Y, Ye J, Yin J, Wei L. | 07/24/2021 |
| Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice. | Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice.
Lang S, Wei R, Wei T, Gu L, Feng J, Yan H, Yang J, Hong T. | 07/3/2021 |
| Both glucagon-receptor signaling and insulin-receptor signaling mutually contribute to blood glucose homeostasis and amino acid metabolism in mice. Glucagon receptor antagonism increased amino acids, lowered glycemia, and increased glucagon but did not influence insulin concentrations. | Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling.
Galsgaard KD, Winther-Sørensen M, Pedersen J, Kjeldsen SAS, Rosenkilde MM, Wewer Albrechtsen NJ, Holst JJ. | 12/21/2019 |
| Apart from their hyperaminoacidemia, Gcgr(-/-) mice display hyperglucagonemia, increased pancreatic content of glucagon and somatostatin (but not insulin), and alpha-cell hyperplasia and hypertrophy compared with WT littermates. | Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis.
Galsgaard KD, Winther-Sørensen M, Ørskov C, Kissow H, Poulsen SS, Vilstrup H, Prehn C, Adamski J, Jepsen SL, Hartmann B, Hunt J, Charron MJ, Pedersen J, Wewer Albrechtsen NJ, Holst JJ., Free PMC Article | 02/23/2019 |
| Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr agonism requires intact Fxr signaling and Fgf21 secretion in liver. (Gcgr = glucagon receptor glucagon; Fxr = farnesoid X receptor; Fgf21 = fibroblast growth factor-21) | Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.
Kim T, Nason S, Holleman C, Pepin M, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschöp M, Habegger KM., Free PMC Article | 09/8/2018 |
| we show that glucagon receptor (GCGR) inhibition with a monoclonal antibody normalized blood glucose and beta-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic beta-cell mass threefold. Normalization of blood glucose levels with GCGR-blocking antibody unexpectedly doubled beta-cell mass relative to that observed with S961 alone and 5.8-fold over control | Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.
Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Cheng X, Murphy AJ, Yancopoulos GD, Gromada J., Free PMC Article | 04/21/2018 |
| These results show that Slc38a5 is a key component of the feedback circuit between glucagon receptor signaling in the liver and amino-acid-dependent regulation of pancreatic alpha cell mass in mice. | Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.
Kim J, Okamoto H, Huang Z, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li WH, Gromada J., Free PMC Article | 03/10/2018 |
| GcgR knockout (Gcgr(-/-)) mice displayed lower blood glucose levels accompanied by elevated plasma ghrelin levels. Hyperglycemia was averted in streptozocin treated Gcgr(-/-) mice and the plasma ghrelin level was further increased. | Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.
Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM., Free PMC Article | 09/2/2017 |
| glucagon receptor antagonist improves glycemia in diet-induced obese angptl4 knockout mice without increasing glucagon levels or alpha-cell proliferation, underscoring the importance of this protein. | Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.
Ben-Zvi D, Barrandon O, Hadley S, Blum B, Peterson QP, Melton DA., Free PMC Article | 05/14/2016 |
| Data indicate that the exocrine pancreas in the glucagon receptor Gcgr-/- mice exhibited larger nuclear size than in WT or heterozygous controls, most obviously at old ages. | Exocrine pancreas hyperplasia without dysplasia in glucagon receptor knockout mice.
Yu R, Nissen NN, Dhall D. | 08/16/2014 |
| Simultaneous and sufficient activation of GLP1R is required to reduce GCCR mediated blood glucose elevation following administration of a GLP1R/GCGR co-agonist. | Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.
Day JW, Gelfanov V, Smiley D, Carrington PE, Eiermann G, Chicchi G, Erion MD, Gidda J, Thornberry NA, Tschöp MH, Marsh DJ, SinhaRoy R, DiMarchi R, Pocai A. | 04/12/2014 |
| Knockdown of liver glucagon receptor in mice reduces blood glucose and increases blood LDL levels. | Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice.
Han S, Akiyama TE, Previs SF, Herath K, Roddy TP, Jensen KK, Guan HP, Murphy BA, McNamara LA, Shen X, Strapps W, Hubbard BK, Pinto S, Li C, Li J., Free PMC Article | 03/29/2014 |
| Gcgr(-/-) mice became lethargic & cachexic & died early. Autopsy revealed numerous PNETs up to 15 mm in diameter in most well-preserved Gcgr(-/-) pancreata. | Glucagon receptor is required for long-term survival: a natural history study of the Mahvash disease in a murine model.
Yu R, Ren SG, Mirocha J. | 02/8/2014 |
| Data suggest that GcgR activation raises hepatic expression of fibroblast growth factor 21 (FGF21) and increases circulating levels of FGF21; GcgR activation induces body weight loss and stimulates lipid metabolism. | Fibroblast growth factor 21 mediates specific glucagon actions.
Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH., Free PMC Article | 06/29/2013 |
| These results suggest that a circulating factor generated after disruption of hepatic Gcgr signaling can increase alpha-cell proliferation independent of direct pancreatic input. | Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.
Longuet C, Robledo AM, Dean ED, Dai C, Ali S, McGuinness I, de Chavez V, Vuguin PM, Charron MJ, Powers AC, Drucker DJ., Free PMC Article | 05/25/2013 |
| GRA1 is a potent glucagon receptor antagonist with strong antihyperglycemic efficacy in preclinical models and prominent effects on hepatic gene-expression related to amino acid metabolism | Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist.
Mu J, Qureshi SA, Brady EJ, Muise ES, Candelore MR, Jiang G, Li Z, Wu MS, Yang X, Dallas-Yang Q, Miller C, Xiong Y, Langdon RB, Parmee ER, Zhang BB., Free PMC Article | 05/25/2013 |
| Data suggest that both Gcgr activity and glucagon-like peptide 1/Glp1r signal transduction in central nervous system are involved in control of interscapular brown adipose tissue thermogenesis. | Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.
Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D., Free PMC Article | 01/26/2013 |
| A novel transgenic mouse was generated which had muscle specific expression of glucagon receptor. The transgenic mice maintained an appropriate ratio of glucagon to insulin, which appears important in maintaining glucose homeostasis. | Ectopic expression of glucagon receptor in skeletal muscles improves glucose homeostasis in a mouse model of diabetes.
Maharaj A, Zhu L, Huang F, Qiu H, Li H, Zhang CY, Jin T, Wang Q. | 08/25/2012 |