| Aberrant Gcm1 expression mediates Wnt/beta-catenin pathway activation in folate deficiency involved in neural tube defects. | Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects.
Li J, Xie Q, Gao J, Wang F, Bao Y, Wu L, Yang L, Liu Z, Guo R, Khan A, Dan Liu, Li C, Wu J, Xie J., Free PMC Article | 09/18/2021 |
| Gcm1 is involved in cell proliferation and fibrosis during kidney regeneration after ischemia-reperfusion injury. | Gcm1 is involved in cell proliferation and fibrosis during kidney regeneration after ischemia-reperfusion injury.
Kamejima S, Tatsumi N, Anraku A, Suzuki H, Ohkido I, Yokoo T, Okabe M., Free PMC Article | 10/24/2020 |
| GCM1-directed villous trophoblast differentiation is repressed by DREAM | DREAM mediated regulation of GCM1 in the human placental trophoblast.
Baczyk D, Kibschull M, Mellstrom B, Levytska K, Rivas M, Drewlo S, Lye SJ, Naranjo JR, Kingdom JC., Free PMC Article | 08/31/2013 |
| Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked. | Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T. | 05/19/2012 |
| as in mice, fetoplacental vascularity increased when GCM1 protein expression decreased (R(2)=-0.45; P<0.05). | Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.
Bainbridge SA, Minhas A, Whiteley KJ, Qu D, Sled JG, Kingdom JC, Adamson SL. | 04/21/2012 |
| Gcm1 (glial cells missing 1) are involved in the epigenetic regulation of Hes5 transcription by DNA demethylation independently of DNA replication. | Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.
Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K. | 09/24/2011 |
| studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 and syncytiotrophoblast formation via acetylation | p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth.
Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B. | 07/23/2011 |
| Gcm1 is co-expressed with Cebpa and Synb in basal cells in contact with the allantois. | Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth.
Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, Cross JC., Free PMC Article | 01/21/2010 |
| Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1 | Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1.
Schubert SW, Lamoureux N, Kilian K, Klein-Hitpass L, Hashemolhosseini S. | 01/21/2010 |
| mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development | Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.
Hashemolhosseini S, Hadjihannas M, Stolt CC, Haas CS, Amann K, Wegner M. | 01/21/2010 |
| Brief ectopic expression of Gcm1 in mouse embryonic tail bud induces failure of the neural tube to close (spina bifida) and multiple neural tubes (diastematomyelia). | Ectopic expression of Gcm1 induces congenital spinal cord abnormalities.
Nait-Oumesmar B, Stecca B, Fatterpekar G, Naidich T, Corbin J, Lazzarini RA. | 01/21/2010 |
| Regulation of subcellular localization has important implications for GCMa/Gcm-1 function. | Structural requirements for nuclear localization of GCMa/Gcm-1.
Hashemolhosseini S, Kilian K, Kardash E, Lischka P, Stamminger T, Wegner M. | 01/21/2010 |
| GCM domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain. | The GCM domain is a Zn-coordinating DNA-binding domain.
Cohen SX, Moulin M, Schilling O, Meyer-Klaucke W, Schreiber J, Wegner M, Müller CW. | 01/21/2010 |
| the shaping of the maternal blood spaces within the labyrinth was dependent on chorioallantoic morphogenesis and therefore disrupted in Gcm1 mutants | Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta.
Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC. | 01/21/2010 |
| Data describe the crystal structure of the glial cell missing (GCM) domain from murine GCMa bound to its octameric DNA target site at 2.85 A resolution. | Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition.
Cohen SX, Moulin M, Hashemolhosseini S, Kilian K, Wegner M, Müller CW., Free PMC Article | 01/21/2010 |
| Pitx proteins influence GCMa-dependent promoter activation in a cell-specific manner | Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2.
Schubert SW, Kardash E, Khan MA, Cheusova T, Kilian K, Wegner M, Hashemolhosseini S. | 01/21/2010 |
| Gcm1 expression defines three stages of chorio-allantoic interaction during placental development | Gcm1 expression defines three stages of chorio-allantoic interaction during placental development.
Stecca B, Nait-Oumesmar B, Kelley KA, Voss AK, Thomas T, Lazzarini RA. | 01/21/2010 |
| Gcm1 promotes cell cycle exit and restriction towards the syncytiotrophoblast cell fate. | The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells.
Hughes M, Dobric N, Scott IC, Su L, Starovic M, St-Pierre B, Egan SE, Kingdom JC, Cross JC. | 01/21/2010 |