| Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease. | Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
Shao X, Wang K, Wu J, Ma X, Zhao Y, Xu T, Dai C, Zhang F, Wang Y, Ren X, Lu K, Yin Z, Guo B, Cao C, Xu X, Xue B. | 10/25/2024 |
| CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway. | CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.
Wang L, Lin Q, Wei B, Guo Y, Li Q, Wang Z, Wu L, Zhang Y, Yin J, Wan B. | 11/3/2023 |
| Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury. | Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
Li D, Li C, Wang T, Zhang C, Zhu Z, Zhang G, Fang B. | 02/12/2022 |
| Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo. | Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo.
Chong D, Chen Z, Guan S, Zhang T, Xu N, Zhao Y, Li C. | 01/22/2022 |
| Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. | Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.
Sang YJ, Wang Q, Zheng F, Hua Y, Wang XY, Zhang JZ, Li K, Wang HQ, Zhao Y, Zhu MS, Sun HX, Li CJ., Free PMC Article | 01/22/2022 |
| Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism. | Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
Jia WJ, Tang QL, Jiang S, Sun SQ, Xue B, Qiu YD, Li CJ, Mao L. | 05/15/2021 |
| The expression level of geranylgeranyl diphosphate synthase (Ggpps), is lower in Non-obstructive azoospermia (NOA) patients than that in obstructive azoospermia (OA) patients. After Ggpps deletion specifically in Sertoli cells (SCs), the mice are infertile and the phenotype of the SC-Ggpps(-/-) mice is similar to the NOA patients, where the blood-testis barrier and the SC-germ cells adhesions are severely destroyed. | The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis.
Zhu R, Wang J, Feng T, Hu X, Jiang C, Wang X, Li K, Sang Y, Hua Y, Sun H, Yao B, Li C., Free PMC Article | 07/18/2020 |
| The GGPPS deficiency activated lung fibroblast by facilitating transforming growth factor beta1 while antagonizing bone morphogenetic protein 4 signaling. The GGPPS provides protection against pulmonary fibrosis and that the restoration of protein geranylgeranylation may benefit statin-induced lung injury. | Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling.
Chen M, Wan B, Zhu S, Zhang F, Jin J, Li X, Wang X, Lv Y, Chen C, Lv T, Song Y. | 04/18/2020 |
| Geranylgeranyl pyrophosphate synthase mediated protein geranylgeranylation plays an indispensable role in the ventricular chamber maturation and acts as a stage-specific signal to regulate the establishment of cardiac cytoarchitecture during mid-gestation. | Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart.
Chen Z, Xu N, Chong D, Guan S, Jiang C, Yang Z, Li C. | 08/17/2019 |
| Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation | Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice.
Diao F, Jiang C, Wang XX, Zhu RL, Wang Q, Yao B, Li CJ., Free PMC Article | 07/7/2018 |
| the specific deletion of Ggps1, using the Collagen 2-CreER(T2) mice, will accelerate the fracture healing process by activating the Bmp2/Smad-dependent Runx2 pathway. | Knockdown of Ggps1 in chondrocyte expedites fracture healing by accelerating the progression of endochondral ossification in mice.
Dai B, Li Q, Song X, Ge Y, Wu J, Zhang K, Wang C, Zhang Y, Teng H, Li C, Jiang Q. | 05/5/2018 |
| Depletion of GGPP in mouse oocytes impaired the proliferation of granulosa cells, primary-secondary follicle transition and female fertility. GGPP depletion inhibited Rho GTPase geranylgeranylation and its GTPase activity. | GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary.
Jiang C, Diao F, Sang YJ, Xu N, Zhu RL, Wang XX, Chen Z, Tao WW, Yao B, Sun HX, Huang XX, Xue B, Li CJ., Free PMC Article | 05/27/2017 |
| our data suggest that GGPPS is essential for maintaining fetal lung branching morphogenesis, which is possibly through regulating K-Ras prenylation. | Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation.
Jia WJ, Jiang S, Tang QL, Shen D, Xue B, Ning W, Li CJ. | 05/13/2017 |
| GGPPS-controlled protein geranylgeranylation, which regulates formation of the insulin granule docked pool, is critical for beta cell function and insulin release during the development of type 2 diabetes mellitus | GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation.
Jiang S, Shen D, Jia WJ, Han X, Shen N, Tao W, Gao X, Xue B, Li CJ. | 05/28/2016 |
| findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity. | GGPPS deficiency aggravates CCl4-induced liver injury by inducing hepatocyte apoptosis.
Chen WB, Lai SS, Yu DC, Liu J, Jiang S, Zhao DD, Ding YT, Li CJ, Xue B. | 07/4/2015 |
| Data suggest that farnesyltransferase might constitute a target in the management of severe acute pancreatitis (AP). | Farnesyltransferase regulates neutrophil recruitment and tissue damage in acute pancreatitis.
Merza M, Awla D, Hwaiz R, Rahman M, Appelros S, Abdulla A, Regner S, Thorlacius H. | 12/20/2014 |
| the impact of deleting one copy of FT or GGT on the development of amyloid-beta (Abeta)-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice. | Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease.
Cheng S, Cao D, Hottman DA, Yuan L, Bergo MO, Li L., Free PMC Article | 02/15/2014 |
| The authors show that an early response transcription factor Egr-1 could tilt the signalling balance by blocking PI3K/Akt signalling through PTEN and augmenting Erk/MAPK signalling through GGPPS, resulting in insulin resistance in adipocytes. | Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice.
Yu X, Shen N, Zhang ML, Pan FY, Wang C, Jia WP, Liu C, Gao Q, Gao X, Xue B, Li CJ., Free PMC Article | 11/5/2011 |
| the Egr-1/GGPPS/Erk1/2 pathway is responsible for insulin resistance during hyperinsulinism | An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism.
Shen N, Yu X, Pan FY, Gao X, Xue B, Li CJ., Free PMC Article | 07/2/2011 |
| these results reveal a new EGR-1/GGPPS/MAPK signaling pathway that controls cigarette smoke-induced pulmonary inflammation. | Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling.
Shen N, Gong T, Wang JD, Meng FL, Qiao L, Yang RL, Xue B, Pan FY, Zhou XJ, Chen HQ, Ning W, Li CJ., Free PMC Article | 04/23/2011 |
| GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved. | Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1.
Yoshida T, Asanuma M, Grossmann L, Fuse M, Shibata T, Yonekawa T, Tanaka T, Ueno K, Yasuda T, Saito Y, Tatsuno I. | 01/21/2010 |