| Stimulating intestinal GIP release reduces food intake and body weight in mice. | Stimulating intestinal GIP release reduces food intake and body weight in mice.
Lewis JE, Nuzzaci D, James-Okoro PP, Montaner M, O'Flaherty E, Darwish T, Hayashi M, Liberles SD, Hornigold D, Naylor J, Baker D, Gribble FM, Reimann F., Free PMC Article | 05/30/2024 |
| Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays. | Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays.
Boer GA, Hartmann B, Holst JJ., Free PMC Article | 12/4/2021 |
| Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes. | Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes.
English A, Craig SL, Flatt PR, Irwin N. | 06/19/2021 |
| Absence of GIP secretion alleviates age-related obesity and insulin resistance. | Absence of GIP secretion alleviates age-related obesity and insulin resistance.
Kanemaru Y, Harada N, Shimazu-Kuwahara S, Yamane S, Ikeguchi E, Murata Y, Kiyobayashi S, Hatoko T, Inagaki N., Free PMC Article | 10/24/2020 |
| HNF4alpha is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide. | HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide.
Girard R, Darsigny M, Jones C, Maloum-Rami F, Gélinas Y, Carpentier AC, Laplante M, Perreault N, Boudreau F., Free PMC Article | 09/26/2020 |
| GIP receptor-knockout (Gipr(-/-)) mice fed normal diet showed an extended lifespan | Inhibition of GIP signaling extends lifespan without caloric restriction.
Hoizumi M, Sato T, Shimizu T, Kato S, Tsukiyama K, Narita T, Fujita H, Morii T, Sassa MH, Seino Y, Yamada Y. | 07/11/2020 |
| In high-fat diet-induced obese (DIO) mice, plasma gastric inhibitory polypeptide (GIP) was increased along with an increase in GIP mRNA expression in the lower small intestine. | Diet-Induced Obese Mice and Leptin-Deficient Lep(ob/ob) Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.
Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T., Free PMC Article | 02/15/2020 |
| pancreatic cancer-derived exosomes (Exo-Mia) suppress the synthesis of GIP and GLP-1 from STC-1cells in vitro by down-regulating the PCSK1/3 | Pancreatic cancer-derived exosomes suppress the production of GIP and GLP-1 from STC-1 cells in vitro by down-regulating the PCSK1/3.
Zhang Y, Huang S, Li P, Chen Q, Li Y, Zhou Y, Wang L, Kang M, Zhang B, Yang B, Dong X, Wu Y. | 09/14/2019 |
| inhibition of hydrolysis of carbohydrates by alpha-glucosidase inhibitors in the gut reduces GIP secretion through a microbiota/SCFA/FFAR3 pathway | Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway.
Lee EY, Zhang X, Miyamoto J, Kimura I, Taknaka T, Furusawa K, Jomori T, Fujimoto K, Uematsu S, Miki T. | 09/14/2019 |
| GIP stimulation induces a switch in GIPR recycling from a rapid endosomal to a slow trans-Golgi network (TGN) pathway. GPCR kinases and b-arrestin2 are required for this switch in recycling. | Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway.
Abdullah N, Beg M, Soares D, Dittman JS, McGraw TE., Free PMC Article | 12/2/2017 |
| GIP provides a novel link between the immune system and the gut, with proinflammatory-immune modulatory function but minor glucose regulatory relevance in the context of acute endotoxemia. | Glucose-dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin-1-dependent manner in mice.
Kahles F, Meyer C, Diebold S, Foldenauer AC, Stöhr R, Möllmann J, Lebherz C, Findeisen HM, Marx N, Lehrke M. | 11/4/2017 |
| our data suggest that the metabolic hormone GIP plays an important role in bone marrow hematopoiesis | Glucose-Dependent Insulinotropic Polypeptide Receptor Deficiency Leads to Impaired Bone Marrow Hematopoiesis.
Mantelmacher FD, Fishman S, Cohen K, Pasmanik Chor M, Yamada Y, Zvibel I, Varol C. | 09/16/2017 |
| these findings identify distinct roles for DPP4 in the endothelial cell versus the bone marrow compartment for selective incretin degradation and DPP4 inhibition-mediated glucoregulation. | Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.
Mulvihill EE, Varin EM, Gladanac B, Campbell JE, Ussher JR, Baggio LL, Yusta B, Ayala J, Burmeister MA, Matthews D, Bang KWA, Ayala JE, Drucker DJ. | 07/15/2017 |
| These results strongly suggest that incretins upregulate the TNF-alpha-stimulated IL6 synthesis in osteoblasts, and that the amplifying effect of incretin is exerted via reducing the IkappaB/NFkappaB pathway through the adenylyl cyclase-cAMP system. | Incretins amplify TNF-α-stimulated IL-6 synthesis in osteoblasts: Suppression of the IκB/NF-κB pathway.
Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T. | 04/29/2017 |
| It was demonstrated that cardiomyocytes represent a direct target of GIP action in vitro, and that GIP ameliorated AngII-induced cardiac hypertrophy via suppression of cardiomyocyte enlargement, apoptosis, and fibrosis in vivo. | Suppressive Effects of Glucose-Dependent Insulinotropic Polypeptide on Cardiac Hypertrophy and Fibrosis in Angiotensin II-Infused Mouse Models.
Hiromura M, Mori Y, Kohashi K, Terasaki M, Shinmura K, Negoro T, Kawashima H, Kogure M, Wachi T, Watanabe R, Sato K, Kushima H, Tomoyasu M, Nakano Y, Yamada Y, Watanabe T, Hirano T. | 02/25/2017 |
| Galanin, acting via the GAL1 receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 and GIP secretion | Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.
Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM., Free PMC Article | 12/17/2016 |
| The loss of food-induced GIP response in Roux-limb of intestine likely contributes to the attenuated serum GIP response to feeding. | Gastric inhibitory polypeptide (GIP) is selectively decreased in the roux-limb of dietary obese mice after RYGB surgery.
Zhou J, Hao Z, Irwin N, Berthoud HR, Ye J., Free PMC Article | 05/21/2016 |
| GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of endothelin-1 and activation of CREB. GIPR mRNA is higher in symptomatic carotid endarterectomy patients. | Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brøns C, Forsblom C, Jonsson A, Zetterqvist AV, Nitulescu M, McDavitt CR, Dunér P, Stancáková A, Kuusisto J, Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M, Nilsson P, Groop PH, Vaag A, Lindblad B, Gottsäter A, Laakso M, Goncalves I, Groop L, Gomez MF. | 04/30/2016 |
| These studies support the hypothesis that a reduction in GIP signaling using a GIP-neutralizing mAb might provide a useful method for the treatment and prevention of obesity and related disorders. | Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice.
Boylan MO, Glazebrook PA, Tatalovic M, Wolfe MM. | 04/16/2016 |
| This study provides evidences that GIP acts directly on osteoblasts and is capable of improving collagen maturity and fibril diameter. | Glucose-dependent insulinotropic polypeptide (GIP) directly affects collagen fibril diameter and collagen cross-linking in osteoblast cultures.
Mieczkowska A, Bouvard B, Chappard D, Mabilleau G. | 11/28/2015 |
| There was decrease in GIP gene transcripts and protein in the gut of HNF1a-null mice. | Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)-Deficient Mice.
Brial F, Lussier CR, Belleville K, Sarret P, Boudreau F. | 11/21/2015 |
| The patterns of colocalisation of the K cell marker, glucagon-like insulinotropic peptide, and the L cell markers, glucagon like peptide-1 and peptide YY, in enteroendocrine cells of the small intestine and colon of mouse and pig, were investigated. | Differences in hormone localisation patterns of K and L type enteroendocrine cells in the mouse and pig small intestine and colon.
Cho HJ, Kosari S, Hunne B, Callaghan B, Rivera LR, Bravo DM, Furness JB. | 10/31/2015 |
| These data indicate that GLP-1 but not GIP is a key mediator of beta cell mass expansion and related adaptations in pregnancy, triggered in part by generation of intra-islet GLP-1. | Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy.
Moffett RC, Vasu S, Thorens B, Drucker DJ, Flatt PR., Free PMC Article | 10/24/2015 |
| NUCB2/nesfatin-1 is co-localized with GLP-1 and GIP in small intestinal cells. Data support the hypothesis that nesfatin-1 is present in enteroendocrine cells and that it stimulates incretin secretion. | Nesfatin-1 stimulates glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide secretion from STC-1 cells in vitro.
Ramesh N, Mortazavi S, Unniappan S. | 08/8/2015 |
| Circulating levels of GIP were significantly decreased in FABP5-deficient mice. | RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion.
Sommer CA, Mostoslavsky G., Free PMC Article | 07/25/2015 |