| Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil. | Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil.
Braga M, Shiga MAS, Silva PES, Yamanaka AHU, Souza VH, Grava S, Simão ANC, Neves JSF, de Lima Neto QA, Zacarias JMV, Visentainer JEL. | 08/14/2024 |
| [Association of gene polymorphisms of MyD88 and TICAM1 and their interactions with community-acquired pneumonia in children]. | [Association of gene polymorphisms of MyD88 and TICAM1 and their interactions with community-acquired pneumonia in children].
Yang Y, Yang SY, Chen ZB, Liu L., Free PMC Article | 09/6/2023 |
| Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis. | Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis.
Bierwagen J, Wiegand M, Laakmann K, Danov O, Limburg H, Herbel SM, Heimerl T, Dorna J, Jonigk D, Preußer C, Bertrams W, Braun A, Sewald K, Schulte LN, Bauer S, Pogge von Strandmann E, Böttcher-Friebertshäuser E, Schmeck B, Jung AL., Free PMC Article | 04/1/2023 |
| Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling. | Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling.
Cagliero J, Vernel-Pauillac F, Murray G, Adler B, Matsui M, Werts C., Free PMC Article | 07/16/2022 |
| MicroRNA-181b-2 and MicroRNA-21-1 Negatively Regulate NF-kappaB and IRF3-Mediated Innate Immune Responses via Targeting TRIF in Teleost. | MicroRNA-181b-2 and MicroRNA-21-1 Negatively Regulate NF-κB and IRF3-Mediated Innate Immune Responses via Targeting TRIF in Teleost.
Sun Y, Zhang L, Hong L, Zheng W, Cui J, Liu X, Xu T., Free PMC Article | 02/12/2022 |
| Correlation between TICAM1 gene polymorphisms and community-acquired pneumonia in children. | Correlation between TICAM1 gene polymorphisms and community-acquired pneumonia in children.
Yang Y, Yang S, Chen Z, Liu L. | 05/1/2021 |
| TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. | TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.
Ciesielska A, Matyjek M, Kwiatkowska K., Free PMC Article | 03/6/2021 |
| Evolutionary model of protein secondary structure capable of revealing new biological relationships. | Evolutionary model of protein secondary structure capable of revealing new biological relationships.
Lai JS, Rost B, Kobe B, Bodén M. | 01/23/2021 |
| New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis. | New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis.
Minsart C, Liefferinckx C, Lemmers A, Dressen C, Quertinmont E, Leclercq I, Devière J, Moreau R, Gustot T., Free PMC Article | 12/5/2020 |
| TIR-domain-containing adapter-inducing interferon-beta contributes to TLR3/TLR4 triggered apoptosis and inflammation in nucleus pulposus cells. | TIR-domain-containing adapter-inducing interferon-β contributes to TLR3/TLR4 triggered apoptosis and inflammation in nucleus pulposus cells.
Lv HL, Yu J, Pei JF, Wang HY, Guo ZL. | 11/21/2020 |
| Phosphorylation of TRIF at Serine 210 is required for IRF-3 recruitment and subsequent IRF-3 activation.Kinase activity of TBK1 is required for the association of TRIF and IRF-3. | Priming Phosphorylation of TANK-Binding Kinase 1 by IκB Kinase β Is Essential in Toll-Like Receptor 3/4 Signaling.
Abe H, Satoh J, Shirasaka Y, Kogure A, Kato H, Ito S, Fujita T., Free PMC Article | 07/25/2020 |
| SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. | SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages.
Yurchenko M, Skjesol A, Ryan L, Richard GM, Kandasamy RK, Wang N, Terhorst C, Husebye H, Espevik T., Free PMC Article | 03/23/2019 |
| These data indicate a novel role of the TLR3-TICAM-1 pathway in controlling miR-21 levels in extracellular vesicles. | Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells.
Fukushima Y, Okamoto M, Ishikawa K, Kouwaki T, Tsukamoto H, Oshiumi H. | 09/15/2018 |
| Findings suggest that Toll/IL-1R domain-containing adapter-inducing IFN-beta may be involved in the epileptogenesis of temporal lobe epilepsy, which would make it a potential therapeutic target for the treatment of epilepsy. | TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation.
Wang FX, Yang XL, Ma YS, Wei YJ, Yang MH, Chen X, Chen B, He Q, Yang QW, Yang H, Liu SY. | 07/14/2018 |
| The down regulation of TRIF, TLR3, and mitochondrial antiviral signaling protein (MAVS) expressions in chronic hepatitis C correlates with the disease severity and the outcome of hepatitis C virus infection | Down regulation of TRIF, TLR3, and MAVS in HCV infected liver correlates with the outcome of infection.
Kar P, Kumar D, Gumma PK, Chowdhury SJ, Karra VK. | 06/2/2018 |
| TRIM56 may act as a tumor suppressor in multiple myeloma through activation of TLR3/TRIF signaling pathway. | TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.
Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M., Free PMC Article | 03/24/2018 |
| Data suggest that endosomal localization of TICAM2 is essential for TLR4-mediated type I interferon-inducing signaling from endosomes; TICAM2 acts as scaffold protein and activates TICAM1; N-terminal myristoylation allows TICAM2 to anchor to endosomal membrane. (TICAM2 = toll like receptor adaptor molecule-2; TICAM1 = toll like receptor adaptor molecule-1; TLR4 = toll-like receptor 4) [REVIEW] | Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Funami K, Matsumoto M, Oshiumi H, Inagaki F, Seya T. | 12/30/2017 |
| Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (TRIF) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF/RIPK1/caspase-8 occurs in fibrillary platforms. | TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy.
Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Häcker G. | 10/7/2017 |
| Therefore, Seneca Valley virus suppressed antiviral interferon production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS, TRIF, and TANK by its 3C protease. | Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.
Qian S, Fan W, Liu T, Wu M, Zhang H, Cui X, Zhou Y, Hu J, Wei S, Chen H, Li X, Qian P., Free PMC Article | 08/12/2017 |
| TRIF gene may contribute to susceptibility of T2DM. | The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental factors on type 2 diabetes mellitus and vascular complications in a Han Chinese population.
Zhou Z, Zeng C, Nie L, Huang S, Guo C, Xiao D, Han Y, Ye X, Ou M, Huang C, Ye X, Wen Z, Yang G, Jing C. | 07/29/2017 |
| The NF-kappaB activated by dsRNA appears not to be the canonical p65/p50 heterodimers. | Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway.
Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X., Free PMC Article | 06/10/2017 |
| We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and HSPA6 and and follicular thyroid cancer | Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population.
Sigurdson AJ, Brenner AV, Roach JA, Goudeva L, Müller JA, Nerlich K, Reiners C, Schwab R, Pfeiffer L, Waldenberger M, Braganza M, Xu L, Sturgis EM, Yeager M, Chanock SJ, Pfeiffer RM, Abend M, Port M., Free PMC Article | 05/20/2017 |
| IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF. | Toll-Like Receptor 3/TRIF-Dependent IL-12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells.
Spelmink L, Sender V, Hentrich K, Kuri T, Plant L, Henriques-Normark B., Free PMC Article | 12/24/2016 |
| TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line | TIRF high-content assay development for the evaluation of drug efficacy of chemotherapeutic agents against EGFR-/HER2-positive breast cancer cell lines.
Ki J, Arumugam P, Song JM. | 12/17/2016 |
| involved in signaling that moderates the expression of heme oxygenase1 and il-8 after keratinocytes exposure to dinitrochlorobenzene | The involvement of the Toll-like receptor signaling and Nrf2-Keap1 pathways in the in vitro regulation of IL-8 and HMOX1 for skin sensitization.
van der Veen JW, Paskel RF, Smits NA, Hodemaekers H, van Loveren H, Ezendam J. | 08/20/2016 |