| The crucial role of NR2A mediating the activation of satellite glial cells in the trigeminal ganglion contributes to orofacial inflammatory pain during TMJ inflammation. | The crucial role of NR2A mediating the activation of satellite glial cells in the trigeminal ganglion contributes to orofacial inflammatory pain during TMJ inflammation.
Song QX, Zhang YY, Li YL, Liu F, Liu YJ, Li YK, Li CJ, Zhou C, Shen JF. | 10/25/2024 |
| Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology. | Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology.
Keith RE, Wild GA, Keith MJ, Chen D, Pack S, Dumas TC., | 06/6/2024 |
| Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity. | Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity.
Deep SN, Seelig S, Paul S, Poddar R., Free PMC Article | 06/6/2024 |
| Early expression of GluN2A-containing NMDA receptors in a model of fragile X syndrome. | Early expression of GluN2A-containing NMDA receptors in a model of fragile X syndrome.
Banke TG, Traynelis SF, Barria A., | 05/1/2024 |
| Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice. | Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice.
Lu Y, Mu L, Elstrott J, Fu C, Sun C, Su T, Ma X, Yan J, Jiang H, Hanson JE, Geng Y, Chen Y., Free PMC Article | 04/18/2024 |
| GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia. | GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.
Harrison PJ, Bannerman DM., Free PMC Article | 12/23/2023 |
| GluN2A mediates ketamine-induced rapid antidepressant-like responses. | GluN2A mediates ketamine-induced rapid antidepressant-like responses.
Su T, Lu Y, Fu C, Geng Y, Chen Y. | 10/4/2023 |
| Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons. | Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.
Camp CR, Vlachos A, Klöckner C, Krey I, Banke TG, Shariatzadeh N, Ruggiero SM, Galer P, Park KL, Caccavano A, Kimmel S, Yuan X, Yuan H, Helbig I, Benke TA, Lemke JR, Pelkey KA, McBain CJ, Traynelis SF., Free PMC Article | 09/28/2023 |
| Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients. | Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
Herzog LE, Wang L, Yu E, Choi S, Farsi Z, Song BJ, Pan JQ, Sheng M., Free PMC Article | 03/20/2023 |
| Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory. | Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory.
Li QQ, Chen J, Hu P, Jia M, Sun JH, Feng HY, Qiao FC, Zang YY, Shi YY, Chen G, Sheng N, Xu Y, Yang JJ, Xu Z, Shi YS. | 12/3/2022 |
| NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease. | NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease.
Haddow K, Kind PC, Hardingham GE., Free PMC Article | 10/22/2022 |
| Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain. | Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain.
Zhang YY, Liu F, Fang ZH, Li YL, Liao HL, Song QX, Zhou C, Shen JF. | 10/22/2022 |
| SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities. | SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities.
Zhang Y, Wu J, Yan Y, Gu Y, Ma Y, Wang M, Zhang H, Tao K, Lü Y, Yu W, Jing W, Wang X, Tian X., Free PMC Article | 05/14/2022 |
| Forebrain GluN2A overexpression impairs fear extinction and NMDAR-dependent long-term depression in the lateral amygdala. | Forebrain GluN2A overexpression impairs fear extinction and NMDAR-dependent long-term depression in the lateral amygdala.
Wang J, Han J, Wang S, Duan Y, Bao C, Luo Y, Xue Q, Cao X. | 03/26/2022 |
| Role of N-methyl-d-aspartate receptor subunits GluN2A and GluN2B in auditory thalamocortical long-term potentiation in adult mice. | Role of N-methyl-d-aspartate receptor subunits GluN2A and GluN2B in auditory thalamocortical long-term potentiation in adult mice.
Zeeman M, Liu X, Zhang O, Yan J. | 01/15/2022 |
| Dopamine and glutamate receptors control social stress-induced striatal ERK1/2 activation. | Dopamine and glutamate receptors control social stress-induced striatal ERK1/2 activation.
Contesse T, Broussot L, Fofo H, Vanhoutte P, Fernandez SP, Barik J. | 01/15/2022 |
| SALM4 negatively regulates NMDA receptor function and fear memory consolidation. | SALM4 negatively regulates NMDA receptor function and fear memory consolidation.
Lie E, Yeo Y, Lee EJ, Shin W, Kim K, Han KA, Yang E, Choi TY, Bae M, Lee S, Um SM, Choi SY, Kim H, Ko J, Kim E., Free PMC Article | 12/25/2021 |
| Voltage-independent GluN2A-type NMDA receptor Ca(2+) signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. | Voltage-independent GluN2A-type NMDA receptor Ca(2+) signaling promotes audiogenic seizures, attentional and cognitive deficits in mice.
Bertocchi I, Eltokhi A, Rozov A, Chi VN, Jensen V, Bus T, Pawlak V, Serafino M, Sonntag H, Yang B, Burnashev N, Li SB, Obenhaus HA, Both M, Niewoehner B, Single FN, Briese M, Boerner T, Gass P, Rawlins JNP, Köhr G, Bannerman DM, Sprengel R., Free PMC Article | 07/3/2021 |
| Knock-in Mice Expressing an Ethanol-Resistant GluN2A NMDA Receptor Subunit Show Altered Responses to Ethanol. | Knock-in Mice Expressing an Ethanol-Resistant GluN2A NMDA Receptor Subunit Show Altered Responses to Ethanol.
Zamudio PA, Smothers TC, Homanics GE, Woodward JJ., Free PMC Article | 02/6/2021 |
| CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells. | CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells.
Xu T, Yu X, Deng J, Ou S, Liu X, Wang T, Liu Y, Yang J, Tan C, Yuan J, Chen Y., Free PMC Article | 08/29/2020 |
| SIRT1 accelerates the progression of activity-based anorexia. | SIRT1 accelerates the progression of activity-based anorexia.
Robinette TM, Nicholatos JW, Francisco AB, Brooks KE, Diao RY, Sorbi S, Ricca V, Nacmias B, Brieño-Enríquez MA, Libert S., Free PMC Article | 08/22/2020 |
| GluN2A NMDAR subunit is required for various neuropathologies associated with lupus autoantibodies. | Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory.
Chan K, Nestor J, Huerta TS, Certain N, Moody G, Kowal C, Huerta PT, Volpe BT, Diamond B, Wollmuth LP., Free PMC Article | 08/1/2020 |
| The second PDZ (PDZ2) domain but not the first or third PDZ domain of Frmpd2 binds to the C-terminus of GluN2A and GluN2B, two subunits of NMDA receptors. | The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.
Lu X, Zhang Q, Wang T. | 07/18/2020 |
| A pristane-induced systemic lupus erythematosus mice model showed downregulation of hippocampal NR2A/NR2B subunits related to cognitive impairment. | Downregulation of hippocampal NR2A/2B subunits related to cognitive impairment in a pristane-induced lupus BALB/c mice.
Luciano-Jaramillo J, Sandoval-García F, Vázquez-Del Mercado M, Gutiérrez-Mercado YK, Navarro-Hernández RE, Martínez-García EA, Pizano-Martínez O, Corona-Meraz FI, Bañuelos-Pineda J, Floresvillar-Mosqueda JF, Martín-Márquez BT., Free PMC Article | 03/14/2020 |
| The authors demonstrate that the developmental N-methyl-D-aspartate receptor (NMDAR) subunit switch from GluN2B to GluN2A is stagnated in Ppt1(-/-) mice. Correspondingly, Ppt1(-/-) neurons exhibit immature evoked NMDAR currents and dendritic spine morphology in vivo. | Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model.
Koster KP, Francesconi W, Berton F, Alahmadi S, Srinivas R, Yoshii A., Free PMC Article | 02/29/2020 |