| NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression. | NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression.
Gao R, Ali T, Liu Z, Li A, He K, Yang C, Feng J, Li S. | 05/2/2024 |
| Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice. | Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.
Jing PB, Chen XH, Lu HJ, Gao YJ, Wu XB., Free PMC Article | 04/2/2022 |
| Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum. | Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum.
Chipman PH, Fung CCA, Pazo Fernandez A, Sawant A, Tedoldi A, Kawai A, Ghimire Gautam S, Kurosawa M, Abe M, Sakimura K, Fukai T, Goda Y., Free PMC Article | 01/29/2022 |
| Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model. | Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
Liu J, Shelkar GP, Sarode LP, Gawande DY, Zhao F, Clausen RP, Ugale RR, Dravid SM., Free PMC Article | 01/1/2022 |
| NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice. | NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.
Chen QY, Li XH, Lu JS, Liu Y, Lee JA, Chen YX, Shi W, Fan K, Zhuo M., Free PMC Article | 12/11/2021 |
| Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes. | Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.
Shelkar GP, Pavuluri R, Gandhi PJ, Ravikrishnan A, Gawande DY, Liu J, Stairs DJ, Ugale RR, Dravid SM., Free PMC Article | 10/24/2020 |
| Triheteromeric GluN1/GluN2A/GluN2C receptors are the predominant NMADRs in cerebellar granule cells and are co-expressed in those cells. | Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells.
Bhattacharya S, Khatri A, Swanger SA, DiRaddo JO, Yi F, Hansen KB, Yuan H, Traynelis SF., Free PMC Article | 08/3/2019 |
| These data reveal a novel mechanism involving plastic modification of synaptically recruited T-type Ca(2+) channels and nucleus Reticularis thalami bursting and indicate a critical role for GluN2C-NMDARs in thalamocortical rhythmogenesis. | Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs.
Fernandez LMJ, Pellegrini C, Vantomme G, Béard E, Lüthi A, Astori S., Free PMC Article | 07/20/2019 |
| GluN2C has a very distinct function in the telencephalon compared to its role in other brain regions. | In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.
Alsaad HA, DeKorver NW, Mao Z, Dravid SM, Arikkath J, Monaghan DT., Free PMC Article | 03/16/2019 |
| The results demonstrate that loss of GluN2C subunit leads to cortical excitatory-inhibitory imbalance and abnormal neuronal oscillations associated with neurodevelopmental disorders. | The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function.
Gupta SC, Ravikrishnan A, Liu J, Mao Z, Pavuluri R, Hillman BG, Gandhi PJ, Stairs DJ, Li M, Ugale RR, Monaghan DT, Dravid SM., Free PMC Article | 06/2/2018 |
| a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia. | Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia.
Chung C, Marson JD, Zhang QG, Kim J, Wu WH, Brann DW, Chen BS., Free PMC Article | 05/19/2018 |
| The GluN2C subunit enhances ischemic stroke pathology by promoting neuronal dysfunction in the penumbra region. | A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke.
Holmes A, Zhou N, Donahue DL, Balsara R, Castellino FJ. | 01/6/2018 |
| glutamatergic glial transmission is sensed by neurons of the dorsal Suprachiasmatic nucleus via specific pre-synaptic NMDA receptor assemblies containing NR2C subunits. | Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Brancaccio M, Patton AP, Chesham JE, Maywood ES, Hastings MH., Free PMC Article | 09/30/2017 |
| Tuberless heterozygote Tsc1+/- mice show functional up-regulation of cortical GluN2C receptors in an mTOR-dependent manner, exhibit recurrent, unprovoked seizures during early postnatal life, that can be treated with GluN2C antagonists. | Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N., Free PMC Article | 11/7/2015 |
| low rectification normally observed in the nucleus reticularis of the thalamus is due to NR2C | NR2C in the thalamic reticular nucleus; effects of the NR2C knockout.
Zhang Y, Buonanno A, Vertes RP, Hoover WB, Lisman JE., Free PMC Article | 01/12/2013 |
| No differences in expression of NR2A, NR2C or NR2D are found in any brain region examined during ethanol consumption and acute ethanol withdrawal. | Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.
Du X, Elberger AJ, Matthews DB, Hamre KM., Free PMC Article | 10/20/2012 |
| Study shows that the NR2C and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1. | Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.
Abe H, Okazawa M, Nakanishi S., Free PMC Article | 08/25/2012 |
| Findings suggest a unique role of NR2C-containing receptors in associative and executive learning. NR2C knockout mice were found to exhibit deficits in fear acquisition and working memory. | Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory.
Hillman BG, Gupta SC, Stairs DJ, Buonanno A, Dravid SM., Free PMC Article | 10/15/2011 |
| indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C | Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).
Cai L, Loo LS, Atlashkin V, Hanson BJ, Hong W., Free PMC Article | 06/4/2011 |
| stimulation of NMDA receptors in conjunction with the AMPA receptor-mediated excitation of granule cells plays a key role in functional subunit switching of NMDA receptors in maturing granule cells at the physiological KCl concentration | Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures.
Iijima K, Abe H, Okazawa M, Moriyoshi K, Nakanishi S., Free PMC Article | 01/21/2010 |
| Results suggest that the replacement of subunit NR2C by NR2B in juvenile mice increases anxiety- and fear-related behaviors possibly due to changes in frontal cortex serotonin and periaqueductal grey acetylcholine levels. | NR2C by NR2B subunit exchange in juvenile mice affects emotionality and 5-HT in the frontal cortex.
De Souza Silva MA, Marchetti L, Eisel UL, Huston JP, Dere E. | 01/21/2010 |
| Expression of GluRepsilon 3 is essential for postsynaptic localization and protein stability of the GluRzeta1 subunit. | NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.
Abe M, Fukaya M, Yagi T, Mishina M, Watanabe M, Sakimura K., Free PMC Article | 01/21/2010 |
| The spiny stellate neurons of barrel cortex layer 4 functionally express NR2C subunits; this is the likely explanation for their ability to generate large NMDAR-mediated EPSPs that are effective at resting potential, without previous depolarization. | NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit.
Binshtok AM, Fleidervish IA, Sprengel R, Gutnick MJ., Free PMC Article | 01/21/2010 |
| results show that the NR2C by NR2B subunit exchange in mice affects ACh content in two target areas of the nucleus basalis | Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels.
De Souza Silva MA, Dolga A, Pieri I, Marchetti L, Eisel UL, Huston JP, Dere E. | 01/21/2010 |