| Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice. | Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice.
Qin Y, Zhang XY, Liu Y, Ma Z, Tao S, Li Y, Peng R, Wang F, Wang J, Feng J, Qiu Z, Jin L, Wang H, Gong X., Free PMC Article | 11/14/2023 |
| A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis. | A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis.
Ramsakha N, Ojha P, Pal S, Routh S, Citri A, Bhattacharyya S., Free PMC Article | 07/7/2023 |
| Protein Networks Associated with Native Metabotropic Glutamate 1 Receptors (mGlu1) in the Mouse Cerebellum. | Protein Networks Associated with Native Metabotropic Glutamate 1 Receptors (mGlu(1)) in the Mouse Cerebellum.
Mansouri M, Kremser L, Nguyen TP, Kasugai Y, Caberlotto L, Gassmann M, Sarg B, Lindner H, Bettler B, Carboni L, Ferraguti F., Free PMC Article | 05/19/2023 |
| Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD. | Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.
Speranza L, Inglebert Y, De Sanctis C, Wu PY, Kalinowska M, McKinney RA, Francesconi A., Free PMC Article | 05/7/2022 |
| circGrm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS. | circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS.
Sun S, Kong Q, Cai Z, Wang M, Zhao H, Zhao C., Free PMC Article | 01/29/2022 |
| Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors. | Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors.
Werthmann RC, Tzouros M, Lamerz J, Augustin A, Fritzius T, Trovò L, Stawarski M, Raveh A, Diener C, Fischer C, Gassmann M, Lindemann L, Bettler B. | 01/15/2022 |
| Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors. | Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.
Upreti C, Woodruff CM, Zhang XL, Yim MJ, Zhou ZY, Pagano AM, Rehanian DS, Yin D, Kandel ER, Stanton PK, Nicholls RE., Free PMC Article | 12/11/2021 |
| Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells. | Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
Guo C, Huson V, Macosko EZ, Regehr WG., Free PMC Article | 10/30/2021 |
| Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. | Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.
Shi G, Yin C, Fan Z, Xing L, Mostovoy Y, Kwok PY, Ashbrook LH, Krystal AD, Ptáček LJ, Fu YH. | 09/4/2021 |
| Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators. | Activation of the mGlu(1) metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M(4) muscarinic receptor allosteric modulators.
Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ., Free PMC Article | 03/20/2021 |
| Elevated Type 1 Metabotropic Glutamate Receptor Availability in a Mouse Model of Huntington's Disease: a Longitudinal PET Study. | Elevated Type 1 Metabotropic Glutamate Receptor Availability in a Mouse Model of Huntington's Disease: a Longitudinal PET Study.
Bertoglio D, Verhaeghe J, Korat Š, Miranda A, Cybulska K, Wyffels L, Stroobants S, Mrzljak L, Dominguez C, Skinbjerg M, Liu L, Munoz-Sanjuan I, Staelens S., Free PMC Article | 01/2/2021 |
| Prion protein interacts with the metabotropic glutamate receptor 1 and regulates the organization of Ca(2+) signaling. | Prion protein interacts with the metabotropic glutamate receptor 1 and regulates the organization of Ca(2+) signaling.
Matsubara T, Satoh K, Homma T, Nakagaki T, Yamaguchi N, Atarashi R, Sudo Y, Uezono Y, Ishibashi D, Nishida N. | 11/21/2020 |
| mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory. | mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory.
Nakao H, Kishimoto Y, Hashimoto K, Kitamura K, Yamasaki M, Nakao K, Watanabe M, Kano M, Kirino Y, Aiba A., Free PMC Article | 10/24/2020 |
| mGlu1 tonically regulates levels of calcium-permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation. | mGlu1 tonically regulates levels of calcium-permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation.
Loweth JA, Reimers JM, Caccamise A, Stefanik MT, Woo KKY, Chauhan NM, Werner CT, Wolf ME., Free PMC Article | 08/13/2020 |
| Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels. | Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.
Xiao S, McKeever PM, Lau A, Robertson J., Free PMC Article | 07/18/2020 |
| Activation of mGluR1, driven by corticothalamic input, regulates multiple stages of the development of lemniscal synapses, including strengthening, refinement, and maintenance in the somatosensory thalamus. | The metabotropic glutamate receptor subtype 1 regulates development and maintenance of lemniscal synaptic connectivity in the somatosensory thalamus.
Narushima M, Yagasaki Y, Takeuchi Y, Aiba A, Miyata M., Free PMC Article | 04/4/2020 |
| Study provides evidence that the function and expression of mGluR1 is enhanced in the spinal cord of an early-symptomatic stage SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS), possibly participating in excessive glutamate transmission and supporting its implication in ALS. | Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression.
Bonifacino T, Rebosio C, Provenzano F, Torazza C, Balbi M, Milanese M, Raiteri L, Usai C, Fedele E, Bonanno G., Free PMC Article | 02/15/2020 |
| SIRT1-shRNA treatment induced pain behavior in normal mice and increased the spinal levels of the mGluR1/5 protein and mRNA. | SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.
Yang C, Kang F, Wang S, Han M, Zhang Z, Li J. | 01/25/2020 |
| suppression of mGluR1 signaling inhibited the dephosphorylation of FMRP and repressed the local translation of synaptic C1q mRNA, which consequently alleviated microglial phagocytosis of synapses and restored the synaptic and cognitive function in the rodent models. | Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer's Rodent Models.
Bie B, Wu J, Foss JF, Naguib M., Free PMC Article | 12/14/2019 |
| The Kif5-SNAP23 complex interacts with mGlu1a receptor (mGLUR1).Kif5 controls microtubule trafficking and membrane targeting of the mGlu1a receptor. | SNAP23-Kif5 complex controls mGlu1 receptor trafficking.
Raynaud F, Homburger V, Seveno M, Vigy O, Moutin E, Fagni L, Perroy J. | 10/26/2019 |
| Data suggest that both, N-terminal and C-terminal region of SNX1 play critical role in the normal trafficking of the group I metabotropic glutamate receptors (mGlur1). In addition, study shows that SNX1 regulates the trafficking of mGluR1 through the interaction with hepatocyte growth factor-regulated tyrosine kinase substrate. | A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.
Sharma R, Gulia R, Bhattacharyya S., Free PMC Article | 10/19/2019 |
| Our results identify a key role for NRG1/ErbB signalling in the regulation of hippocampal mGluRI-dependent synaptic and cognitive functions, whose alteration might contribute to the pathogenesis of different brain diseases. | Neuregulin 1/ErbB signalling modulates hippocampal mGluRI-dependent LTD and object recognition memory.
Ledonne A, Mango D, Latagliata EC, Chiacchierini G, Nobili A, Nisticò R, D'Amelio M, Puglisi-Allegra S, Mercuri NB. | 01/19/2019 |
| Study states that metabotropic glutamate receptor subtype 1 (mGluR1) is critical for elimination of surplus climbing fiber-Purkinje cell synapses in the cerebellum, retinogeniculate synapses require mGluR1 for maintenance of mature connectivity. | Comparison of the role of metabotropic glutamate receptor subtype 1 in developmental refinement of neuronal connectivity between the cerebellum and the sensory thalamus.
Narushima M. | 09/1/2018 |
| Study shows that blocking of metabotropic glutamate type 5 receptor (mGlu5) reduced the dysregulation of glutamate transmission and improved motor coordination in the metabotropic glutamate type 1 receptor (Grm1crv4) mouse model of cerebellar ataxia SCAR13. | Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1(crv4) mouse model of SCAR13 ataxia.
Bossi S, Musante I, Bonfiglio T, Bonifacino T, Emionite L, Cerminara M, Cervetto C, Marcoli M, Bonanno G, Ravazzolo R, Pittaluga A, Puliti A. | 06/30/2018 |
| These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of retinal ganglion cell | Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration.
Liberatore F, Bucci D, Mascio G, Madonna M, Di Pietro P, Beneventano M, Puliti AM, Battaglia G, Bruno V, Nicoletti F, Romano MR. | 06/9/2018 |