| YTHDC1 inhibits osteoclast differentiation to alleviate osteoporosis by enhancing PTPN6 messenger RNA stability in an m6A-hUR-dependent manner. | YTHDC1 inhibits osteoclast differentiation to alleviate osteoporosis by enhancing PTPN6 messenger RNA stability in an m6A-hUR-dependent manner.
Zhang M, Guan J, Yu S, Zhang Y, Cheng L, Zhang Y. | 09/19/2024 |
| [Effect of SHP-1 knockout in airway epithelial cells on emphysema phenotype in chronic obstructive pulmonary disease in mice]. | [Effect of SHP-1 knockout in airway epithelial cells on emphysema phenotype in chronic obstructive pulmonary disease in mice].
Xu SL, Chen Z, Yang J, Fan ZQ, Liu T, Zhang XT, Zeng BQ, Xing XQ. | 04/26/2024 |
| Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease. | Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease.
Lizotte F, Rousseau M, Denhez B, Lévesque D, Guay A, Liu H, Moreau J, Higgins S, Sabbagh R, Susztak K, Boisvert FM, Côté AM, Geraldes P. | 09/28/2023 |
| SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency. | SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency.
Schmied L, Luu TT, Søndergaard JN, Hald SH, Meinke S, Mohammad DK, Singh SB, Mayer C, Perinetti Casoni G, Chrobok M, Schlums H, Rota G, Truong HM, Westerberg LS, Guarda G, Alici E, Wagner AK, Kadri N, Bryceson YT, Saeed MB, Höglund P. | 04/14/2023 |
| SHP-1 Protein Tyrosine Phosphatase Affects Early Postnatal Bone Development in Mice. | SHP-1 Protein Tyrosine Phosphatase Affects Early Postnatal Bone Development in Mice.
Markovics A, Lupo S, Patel N, Mikecz K, Sumner DR, Ross RD. | 03/21/2023 |
| CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation. | CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation.
Mazgaeen L, Yorek M, Saini S, Vogel P, Meyerholz DK, Kanneganti TD, Gurung P., Free PMC Article | 01/21/2023 |
| Repair of Limb Ischemia Is Dependent on Hematopoietic Stem Cell Specific-SHP-1 Regulation of TGF-beta1. | Repair of Limb Ischemia Is Dependent on Hematopoietic Stem Cell Specific-SHP-1 Regulation of TGF-β1.
Wang C, Nistala R, Cao M, Li DP, Pan Y, Golzy M, Cui Y, Liu Z, Kang X., Free PMC Article | 12/31/2022 |
| The regulatory effects of PTPN6 on inflammatory process: Reports from mice to men. | The regulatory effects of PTPN6 on inflammatory process: Reports from mice to men.
Kiratikanon S, Chattipakorn SC, Chattipakorn N, Kumfu S. | 05/7/2022 |
| Ets-2 deletion in myeloid cells attenuates IL-1alpha-mediated inflammatory disease caused by a Ptpn6 point mutation. | Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.
Tartey S, Gurung P, Karki R, Burton A, Hertzog P, Kanneganti TD., Free PMC Article | 04/2/2022 |
| Diabetes Impaired Ischemia-Induced PDGF (Platelet-Derived Growth Factor) Signaling Actions and Vessel Formation Through the Activation of Scr Homology 2-Containing Phosphatase-1. | Diabetes Impaired Ischemia-Induced PDGF (Platelet-Derived Growth Factor) Signaling Actions and Vessel Formation Through the Activation of Scr Homology 2-Containing Phosphatase-1.
Mercier C, Brazeau T, Lamoureux J, Boisvert E, Robillard S, Breton V, Paré M, Guay A, Lizotte F, Despatis MA, Geraldes P. | 09/18/2021 |
| Combinational Approach of Genetic SHP-1 Suppression and Voluntary Exercise Promotes Corticospinal Tract Sprouting and Motor Recovery Following Brain Injury. | Combinational Approach of Genetic SHP-1 Suppression and Voluntary Exercise Promotes Corticospinal Tract Sprouting and Motor Recovery Following Brain Injury.
Tanaka T, Ito T, Sumizono M, Ono M, Kato N, Honma S, Ueno M. | 08/28/2021 |
| Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase. | Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase.
Markovics A, Toth DM, Glant TT, Mikecz K., Free PMC Article | 08/7/2021 |
| Helicobacter pylori CagA Interacts with SHP-1 to Suppress the Immune Response by Targeting TRAF6 for K63-Linked Ubiquitination. | Helicobacter pylori CagA Interacts with SHP-1 to Suppress the Immune Response by Targeting TRAF6 for K63-Linked Ubiquitination.
He H, Liu J, Li L, Qian G, Hao D, Li M, Zhang Y, Hong X, Xu J, Yan D. | 08/7/2021 |
| Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy. | Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy.
Fujiwara N, Shibutani S, Ohama T, Sato K. | 07/3/2021 |
| Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. | Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Myers DR, Abram CL, Wildes D, Belwafa A, Welsh AMN, Schulze CJ, Choy TJ, Nguyen T, Omaque N, Hu Y, Singh M, Hansen R, Goldsmith MA, Quintana E, Smith JAM, Lowell CA., Free PMC Article | 06/19/2021 |
| Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia. | Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia.
Liu BL, Cao QL, Zhao X, Liu HZ, Zhang YQ., Free PMC Article | 05/22/2021 |
| SHP-1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production. | SHP-1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production.
Lin L, Jian J, Song CY, Chen F, Ding K, Xie WF, Hu PF. | 05/15/2021 |
| A CD22-Shp1 phosphatase axis controls integrin beta7 display and B cell function in mucosal immunity. | A CD22-Shp1 phosphatase axis controls integrin β(7) display and B cell function in mucosal immunity.
Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocón B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC., Free PMC Article | 05/1/2021 |
| The immune checkpoint receptor associated phosphatases SHP-1 and SHP-2 are not required for gammadeltaT17 cell development, activation, or skin inflammation. | The immune checkpoint receptor associated phosphatases SHP-1 and SHP-2 are not required for γδT17 cell development, activation, or skin inflammation.
Kadekar D, Agerholm R, Viñals MT, Rizk J, Bekiaris V. | 12/12/2020 |
| Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade. | Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade.
Snook JP, Soedel AJ, Ekiz HA, O'Connell RM, Williams MA., Free PMC Article | 11/21/2020 |
| Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor. | Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor.
Chen HY, Gao LT, Yuan JQ, Zhang YJ, Liu P, Wang G, Ni X, Liu WN, Gao L. | 10/31/2020 |
| synapse formed by 4-1BB-encoding CAR recruits the THEMIS-SHP1 phosphatase complex that attenuates CAR-CD3zeta phosphorylation | THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.
Sun C, Shou P, Du H, Hirabayashi K, Chen Y, Herring LE, Ahn S, Xu Y, Suzuki K, Li G, Tsahouridis O, Su L, Savoldo B, Dotti G., Free PMC Article | 07/25/2020 |
| B cell-intrinsic SHP1 expression promotes the mouse herpesvirus -driven germinal center response and the establishment of chronic infection. | B Cell-Intrinsic SHP1 Expression Promotes the Gammaherpesvirus-Driven Germinal Center Response and the Establishment of Chronic Infection.
Johnson KE, Lange PT, Jondle CN, Volberding PJ, Lorenz UM, Cui W, Dittel BN, Tarakanova VL., Free PMC Article | 06/13/2020 |
| SHP-1 plays an anti-apoptotic role in renal ischemia/reperfusion injury. ASK1 can be dephosphorylated in tyrosine residue(s) by SHP-1. SHP-1 could bind to and dephosphorylate ASK1 to inhibit its activation, thus repressing apoptosis. | SHP-1 inhibits renal ischemia reperfusion injury via dephosphorylating ASK1 and suppressing apoptosis.
Tian H, Tan R, Ye B, Yan S, Sui M, Zhao W, Zhang L, Zhu Y, Zeng L. | 05/2/2020 |
| the data emphasize dual functions for Ptpn6 in the negative regulation of p38 mitogen-activated protein kinase activation to control tumor necrosis factor and IL-1alpha/beta expression, and in maintaining Ripk1 function to prevent caspase-8- and Ripk3-Mlkl-dependent cell death and concomitant IL-1alpha/beta release. | Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
Speir M, Nowell CJ, Chen AA, O'Donnell JA, Shamie IS, Lakin PR, D'Cruz AA, Braun RO, Babon JJ, Lewis RS, Bliss-Moreau M, Shlomovitz I, Wang S, Cengia LH, Stoica AI, Hakem R, Kelliher MA, O'Reilly LA, Patsiouras H, Lawlor KE, Weller E, Lewis NE, Roberts AW, Gerlic M, Croker BA., Free PMC Article | 04/18/2020 |