| Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells. | Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells.
Cousu C, Mulot E, De Smet A, Formichetti S, Lecoeuche D, Ren J, Muegge K, Boulard M, Weill JC, Reynaud CA, Storck S., Free PMC Article | 09/20/2023 |
| Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis. | Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
Prakash Yadav R, Leskinen S, Ma L, Mäkelä JA, Kotaja N., Free PMC Article | 12/10/2022 |
| PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment. | PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
Imai Y, Biot M, Clément JA, Teragaki M, Urbach S, Robert T, Baudat F, Grey C, de Massy B., Free PMC Article | 05/15/2021 |
| LSH mediates gene repression through macroH2A deposition. | LSH mediates gene repression through macroH2A deposition.
Ni K, Ren J, Xu X, He Y, Finney R, Braun SMG, Hathaway NA, Crabtree GR, Muegge K., Free PMC Article | 12/12/2020 |
| The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. | The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T., Free PMC Article | 11/21/2020 |
| Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination. | Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.
He Y, Ren J, Xu X, Ni K, Schwader A, Finney R, Wang C, Sun L, Klarmann K, Keller J, Tubbs A, Nussenzweig A, Muegge K., Free PMC Article | 10/10/2020 |
| Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis. | Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis.
Baumann C, Ma W, Wang X, Kandasamy MK, Viveiros MM, De La Fuente R., Free PMC Article | 09/26/2020 |
| By altering the nucleosome occupancy at the nucleosome-free region and enhancer, HELLS epigenetically suppresses multiple tumor suppressor genes to promote hepatocellular carcinoma progression. | HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma.
Law CT, Wei L, Tsang FH, Chan CY, Xu IM, Lai RK, Ho DW, Lee JM, Wong CC, Ng IO, Wong CM. | 06/20/2020 |
| hot spot activation in which HELLS and PRDM9 form a pioneer complex to create a unique epigenomic environment of open chromatin, permitting correct placement and repair of DSBs | HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots.
Spruce C, Dlamini S, Ananda G, Bronkema N, Tian H, Paigen K, Carter GW, Baker CL., Free PMC Article | 04/25/2020 |
| Lsh assists epigenetic gene repression upon binding to the Oct4 promoter region. | Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.
Ren J, Hathaway NA, Crabtree GR, Muegge K., Free PMC Article | 12/22/2018 |
| These results suggest that Lsh exerts epigenetic regulation at key regulators of neural stem cell fate ensuring adequate neural stem/progenitor cells self-renewal and maintenance during development. | Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells.
Han Y, Ren J, Lee E, Xu X, Yu W, Muegge K., Free PMC Article | 09/22/2018 |
| fibroblasts derived from chromatin remodeling ATPase LSH (HELLS)-null mouse embryos, which lack DNA methylation from centromeric repeats, transposons and a number of gene promoters, are capable of reestablishing DNA methylation and silencing of misregulated genes upon re-expression of LSH. | The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells.
Termanis A, Torrea N, Culley J, Kerr A, Ramsahoye B, Stancheva I., Free PMC Article | 06/10/2017 |
| Data suggest that HELLS controls cytosine methylation in a nuclear compartment that is in part defined by lamin B1 attachment regions. | Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.
Yu W, McIntosh C, Lister R, Zhu I, Han Y, Ren J, Landsman D, Lee E, Briones V, Terashima M, Leighty R, Ecker JR, Muegge K., Free PMC Article | 06/20/2015 |
| histone H3 lysine 4 methylation modification was assessed in murine embryonic fibroblasts (MEFs) derived from the DNA methylation mutant Lsh(-/-) mice. | CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.
Yu W, Briones V, Lister R, McIntosh C, Han Y, Lee EY, Ren J, Terashima M, Leighty RM, Ecker JR, Muegge K., Free PMC Article | 06/21/2014 |
| These results indicate that in the absence of HELLS, proliferation of spermatogonia is reduced and germ cell differentiation arrested at the midpachytene stage, implicating an essential role for HELLS during male meiosis. | Lymphoid-specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes.
Zeng W, Baumann C, Schmidtmann A, Honaramooz A, Tang L, Bondareva A, Dores C, Fan T, Xi S, Geiman T, Rathi R, de Rooij D, De La Fuente R, Muegge K, Dobrinski I., Free PMC Article | 10/1/2011 |
| LSH is essential for developmentally programmed de novo DNA methylation at the promoters of protein coding genes and recruitment of G9a/GLP complex to a subset of genomic loci. | LSH and G9a/GLP complex are required for developmentally programmed DNA methylation.
Myant K, Termanis A, Sundaram AY, Boe T, Li C, Merusi C, Burrage J, de Las Heras JI, Stancheva I., Free PMC Article | 04/23/2011 |
| Data show that hypomethylation in Lsh-/- cells is associated with efficient transcriptional elongation and splicing. | Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation.
Tao Y, Xi S, Briones V, Muegge K., Free PMC Article | 10/4/2010 |
| DNA hypomethylation caused by Lsh depletion is linked to transcriptional upregulation of retroviral elements and oncogenes such as PU.1 which in turn may promote the development of erythroleukemia in mice | DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.
Fan T, Schmidtmann A, Xi S, Briones V, Zhu H, Suh HC, Gooya J, Keller JR, Xu H, Roayaei J, Anver M, Ruscetti S, Muegge K., Free PMC Article | 01/21/2010 |
| Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of polycomb repressive complex targets | Lsh controls Hox gene silencing during development.
Xi S, Zhu H, Xu H, Schmidtmann A, Geiman TM, Muegge K., Free PMC Article | 01/21/2010 |
| PASG mutant mice display signs of growth retardation and premature aging, including low birth weight, failure to thrive, graying and loss of hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia, and premature death. | Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.
Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, Miao D, Huso DL, Arceci RJ., Free PMC Article | 01/21/2010 |
| model in which Lsh is recruited by intact heterochromatin structure and then assists in maintaining heterochromatin organization by establishing CpG methylation patterns | Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin.
Yan Q, Cho E, Lockett S, Muegge K., Free PMC Article | 01/21/2010 |
| Lsh has a critical and previously unidentified role in epigenetic gene silencing and maintenance of genomic stability during female meiosis. | Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells.
De La Fuente R, Baumann C, Fan T, Schmidtmann A, Dobrinski I, Muegge K. | 01/21/2010 |