| Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways. | Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways.
Morris HE, Neves KB, Nilsen M, Montezano AC, MacLean MR, Touyz RM., Free PMC Article | 07/23/2023 |
| A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord. | A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.
Biga V, Hawley J, Soto X, Johns E, Han D, Bennett H, Adamson AD, Kursawe J, Glendinning P, Manning CS, Papalopulu N., Free PMC Article | 01/8/2022 |
| Repression of FBXW7 by HES5 contributes to inactivation of the TGF-beta signaling pathway and alleviation of endometriosis. | Repression of FBXW7 by HES5 contributes to inactivation of the TGF-β signaling pathway and alleviation of endometriosis.
Chen LJ, Hu B, Han ZQ, Liu W, Zhu JH, Chen XX, Li ZP, Zhou H. | 06/26/2021 |
| This increases the decoding capacity of HES5 oscillations and correlates with interneuron versus motor neuron cell fate. | Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis.
Manning CS, Biga V, Boyd J, Kursawe J, Ymisson B, Spiller DG, Sanderson CM, Galla T, Rattray M, Papalopulu N., Free PMC Article | 09/7/2019 |
| Olig2 represses expression of the Notch signaling pathway effectors Hes1 and Hes5 | Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.
Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG., Free PMC Article | 03/23/2019 |
| These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E(-/-) mice, in which downregulation of hes1 and hes5 is involved. | Hyperhomocysteinemia-induced autophagy and apoptosis with downregulation of hairy enhancer of split 1/5 in cortical neurons in mice.
Zhang JW, Yan R, Tang YS, Guo YZ, Chang Y, Jing L, Wang YL, Zhang JZ., Free PMC Article | 08/18/2018 |
| Although Hes5-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis-regulatory elements that regulate endogenous Hes5 in the mouse lens and retina. | Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye.
Riesenberg AN, Conley KW, Le TT, Brown NL., Free PMC Article | 07/28/2018 |
| Hes5 is expressed in the nascent mesoderm of gastrulating mouse embryos. Hes5 knockdown enhances primitive erythropoiesis in mouse embryonic stem cells. A stage-specific pulse of Hes5 instructs preferential cardiac fate in mouse embryonic stem cells. | Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate.
Freire AG, Waghray A, Soares-da-Silva F, Resende TP, Lee DF, Pereira CF, Nascimento DS, Lemischka IR, Pinto-do-Ó P., Free PMC Article | 05/5/2018 |
| Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. | Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation.
Panaliappan TK, Wittmann W, Jidigam VK, Mercurio S, Bertolini JA, Sghari S, Bose R, Patthey C, Nicolis SK, Gunhaga L., Free PMC Article | 04/14/2018 |
| Hes5 regulates the transition timing between phases for specification of neocortical neurons and between neurogenesis and gliogenesis. | Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development.
Bansod S, Kageyama R, Ohtsuka T. | 10/14/2017 |
| the RBPjkappa-dependent Notch targets HES1 and HES5 suppress chondrogenesis and promote the onset of chondrocyte hypertrophy. | HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.
Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ., Free PMC Article | 08/12/2017 |
| This study demonstrated that Hes1 and Hes5 modulate not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development. | Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development.
Goto M, Hojo M, Ando M, Kita A, Kitagawa M, Ohtsuka T, Kageyama R, Miyamoto S. | 08/20/2016 |
| delivery of siRNA to Hes1 and Hes5 using a transfection reagent or siRNA to Hes1 encapsulated within nanoparticles increased hair cell numbers in non-toxin treated organotypic cultures of cochleae and maculae | Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA.
Du X, Li W, Gao X, West MB, Saltzman WM, Cheng CJ, Stewart C, Zheng J, Cheng W, Kopke RD., Free PMC Article | 04/26/2014 |
| The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis | Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.
Murta D, Batista M, Silva E, Trindade A, Henrique D, Duarte A, Lopes-da-Costa L., Free PMC Article | 04/5/2014 |
| Hes1 and Hes5 regulate vascular remodeling and arterial fate specification of endothelial cells in the development of the brain; they are critical transducers of Notch signals in brain vascular development. | Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development.
Kitagawa M, Hojo M, Imayoshi I, Goto M, Ando M, Ohtsuka T, Kageyama R, Miyamoto S. | 03/1/2014 |
| the downstream Notch signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta. | Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.
Sancho R, Blake SM, Tendeng C, Clurman BE, Lewis J, Behrens A., Free PMC Article | 01/11/2014 |
| Data demonstrate that Hes5 levels in the utricle decreased after the application of siRNA and that the number of hair cells in these utricles was significantly larger than following control treatment. | siRNA targeting Hes5 augments hair cell regeneration in aminoglycoside-damaged mouse utricle.
Jung JY, Avenarius MR, Adamsky S, Alpert E, Feinstein E, Raphael Y., Free PMC Article | 11/2/2013 |
| Epigenetic silencing of Hes5 leads to neuronal differentiation despite active Notch signaling. | BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
Tiberi L, van den Ameele J, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen P. | 02/2/2013 |
| Simultaneous overexpression of Hes5 and Sox21 reveals Hes5 as a downstream effector of Sox21 in adult hippocampus neurogenesis. | Sox21 promotes hippocampal adult neurogenesis via the transcriptional repression of the Hes5 gene.
Matsuda S, Kuwako K, Okano HJ, Tsutsumi S, Aburatani H, Saga Y, Matsuzaki Y, Akaike A, Sugimoto H, Okano H., Free PMC Article | 11/17/2012 |
| This study suggested that Hes5 expression is serially activated first by Gcms and later by the canonical Notch pathway | Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.
Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K. | 09/24/2011 |
| Hes1, Hes5 and Hey1 cooperatively inhibit hair cell formation, and one allele of Hes1, Hes5 or Hey1 is sufficient for supporting cell production probably by lateral inhibition in the sensory epithelium. | Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.
Tateya T, Imayoshi I, Tateya I, Ito J, Kageyama R. | 05/28/2011 |
| ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. | ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression.
Masserdotti G, Badaloni A, Green YS, Croci L, Barili V, Bergamini G, Vetter ML, Consalez GG., Free PMC Article | 10/30/2010 |
| Atoh1 up-regulation may either be a result of Hes5 down-regulation or mediated by another signaling pathway during hair cell regeneration in the mouse utricle. | Notch signaling and Atoh1 expression during hair cell regeneration in the mouse utricle.
Wang GP, Chatterjee I, Batts SA, Wong HT, Gong TW, Gong SS, Raphael Y., Free PMC Article | 10/30/2010 |
| Lack of altered phenotype in the conditional HES1;HES5 double mutant mice can be explained by the HES1 and HES5 genes not being involved in cartilage and endochondral bone development or by redundancy between the genes of the family of HES genes. | HES1 and HES5 are dispensable for cartilage and endochondral bone formation.
Karlsson C, Brantsing C, Kageyama R, Lindahl A. | 10/23/2010 |
| Fezf1 and Fezf2 control differentiation of neural stem cells by repressing Hes5 and, in turn, by derepressing neurogenin 2 in the forebrain. | Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain.
Shimizu T, Nakazawa M, Kani S, Bae YK, Shimizu T, Kageyama R, Hibi M. | 06/14/2010 |