| p110CUX1 promotes acute myeloid leukemia progression via regulating pyridoxal phosphatase expression and activating PI3K/AKT/mTOR signaling pathway. | p110CUX1 promotes acute myeloid leukemia progression via regulating pyridoxal phosphatase expression and activating PI3K/AKT/mTOR signaling pathway.
Zhang H, Zhong L, Wang M, Wan P, Chu X, Chen S, Zhou Z, Shao X, Liu B. | 10/15/2024 |
| p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway. | p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway.
Wang M, Zhong L, Zhang H, Wan P, Chu X, Shao X, Chen S, Zhou Z, Yu L, Liu B. | 09/30/2024 |
| CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex. | CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex.
Liu W, Kurkewich JL, Stoddart A, Khan S, Anandan D, Gaubil AN, Wolfgeher DJ, Jueng L, Kron SJ, McNerney ME., Free PMC Article | 09/25/2024 |
| Cathepsin L induces cellular senescence by upregulating CUX1 and p16[INK4a]. | Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a).
Wu Y, Jiang D, Liu Q, Yan S, Liu X, Wu T, Sun W, Li G., Free PMC Article | 08/30/2024 |
| CUX1 attenuates the apoptosis of renal tubular epithelial cells induced by contrast media through activating the PI3K/AKT signaling pathway. | CUX1 attenuates the apoptosis of renal tubular epithelial cells induced by contrast media through activating the PI3K/AKT signaling pathway.
Yue RZ, Wang J, Lin F, Li CJ, Su BH, Zeng R., Free PMC Article | 06/17/2024 |
| Abnormal expression of CUX1 influences autophagy activation in paroxysmal nocturnal hemoglobinuria. | Abnormal expression of CUX1 influences autophagy activation in paroxysmal nocturnal hemoglobinuria.
Wu J, Li L, Liu Z, Wang H, Chen Y, Zeng L, Wang G, Liu H, Fu R. | 05/1/2024 |
| Post-GWAS functional analysis identifies CUX1 as a regulator of p16[INK4a] and cellular senescence. | Post-GWAS functional analysis identifies CUX1 as a regulator of p16(INK4a) and cellular senescence.
Jiang D, Sun W, Wu T, Zou M, Vasamsetti SB, Zhang X, Zhao Y, Phillippi JA, Sawalha AH, Tavakoli S, Dutta P, Florentin J, Chan SY, Tollison TS, Di Wu, Cui J, Huntress I, Peng X, Finkel T, Li G., Free PMC Article | 05/3/2023 |
| Clinically Significant CUX1 Mutations Are Frequently Subclonal and Common in Myeloid Disorders With a High Number of Co-mutated Genes and Dysplastic Features. | Clinically Significant CUX1 Mutations Are Frequently Subclonal and Common in Myeloid Disorders With a High Number of Co-mutated Genes and Dysplastic Features.
Dermawan JK, Wensel C, Visconte V, Maciejewski JP, Cook JR, Bosler DS. | 04/16/2022 |
| Genomic studies controvert the existence of the CUX1 p75 isoform. | Genomic studies controvert the existence of the CUX1 p75 isoform.
Krishnan M, Senagolage MD, Baeten JT, Wolfgeher DJ, Khan S, Kron SJ, McNerney ME., Free PMC Article | 02/26/2022 |
| p113 isoform encoded by CUX1 circular RNA drives tumor progression via facilitating ZRF1/BRD4 transactivation. | p113 isoform encoded by CUX1 circular RNA drives tumor progression via facilitating ZRF1/BRD4 transactivation.
Yang F, Hu A, Guo Y, Wang J, Li D, Wang X, Jin S, Yuan B, Cai S, Zhou Y, Li Q, Chen G, Gao H, Zheng L, Tong Q., Free PMC Article | 02/26/2022 |
| N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway. | N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway.
Wu P, Fang X, Liu Y, Tang Y, Wang W, Li X, Fan Y., Free PMC Article | 10/16/2021 |
| Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating beta-catenin. | Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating β-catenin.
Xu A, Wang X, Luo J, Zhou M, Yi R, Huang T, Lin J, Wu Z, Xie C, Ding S, Zeng Y, Song Y., Free PMC Article | 09/18/2021 |
| Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. | Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC., Free PMC Article | 05/15/2021 |
| Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism. | Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism.
Cardinale CJ, March ME, Lin X, Liu Y, Spruce LA, Bradfield JP, Wei Z, Seeholzer SH, Grant SFA, Hakonarson H. | 04/17/2021 |
| In fibroblasts, IL-17A response depends on CUX1 and IkappaBzeta to engage the NF-kappaB complex to produce chemoattractants for neutrophil and monocyte recruitment. | CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.
Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, Gurish MF, Brenner MB, Raychaudhuri S., Free PMC Article | 07/18/2020 |
| These functional findings may explain why samples with either CUX1 (MT) or low CUX1 expression coincided with significantly higher numbers of somatic hits by whole-exome sequencing. Our findings implicate the DNA repair dysfunction resulting from CUX1 lesions in the pathogenesis of MNs, in which they lead to a mutator phenotype. | Distinct clinical and biological implications of CUX1 in myeloid neoplasms.
Aly M, Ramdzan ZM, Nagata Y, Balasubramanian SK, Hosono N, Makishima H, Visconte V, Kuzmanovic T, Adema V, Nazha A, Przychodzen BP, Kerr CM, Sekeres MA, Abazeed ME, Nepveu A, Maciejewski JP., Free PMC Article | 07/11/2020 |
| CUX1 activated by Snail-Cat L signaling may contribute to TNBC via ER-alpha repression. | CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V., Free PMC Article | 01/11/2020 |
| Haploinsufficiency of CUX1, causes an isolated phenotype of developmental delay or intellectual disability with possible catch-up development. | Haploinsufficiency of CUX1 Causes Nonsyndromic Global Developmental Delay With Possible Catch-up Development.
Platzer K, Cogné B, Hague J, Marcelis CL, Mitter D, Oberndorff K, Park SM, Ploos van Amstel HK, Simonic I, van der Smagt JJ, Stegmann APA, Stevens SJC, Stumpel CTRM, Vincent M, Lemke JR, Jamra R. | 08/24/2019 |
| High CUX1 expression is associated with resistance of glioblastoma cells to temozolomide. | CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide.
Kaur S, Ramdzan ZM, Guiot MC, Li L, Leduy L, Ramotar D, Sabri S, Abdulkarim B, Nepveu A., Free PMC Article | 02/2/2019 |
| the findings demonstrated that mutated K-ras promotes cathepsin L expression and plays a pivotal role in EMT of human lung cancer. The regulatory effect of IR-induced cathepsin L on lung cancer invasion and migration was partially attributed to the Cathepsin L /CUX1-mediated EMT signaling pathway | K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
Wang L, Zhao Y, Xiong Y, Wang W, Fei Y, Tan C, Liang Z. | 10/6/2018 |
| Our data indicate that there exist frameshift mutations of <I>CUX1</I> and <I>SIRT1</I> genes as well as intratumoral heterogeneity of <I>CUX1</I> frameshift mutation in high microsatellite instability cancers, which together might play a role in tumorigenesis of gastric cancer and colorectal cancer with high microsatellite instability | Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers.
Jo YS, Kim MS, Yoo NJ, Lee SH. | 03/24/2018 |
| CUX1 is enriched at sites of DNA looping, as determined by Hi-C analysis, and these loops connect CUX1 to the promoters of regulated genes. | The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters.
Arthur RK, An N, Khan S, McNerney ME., Free PMC Article | 12/2/2017 |
| our results have uncovered the requirement for CUX1 expression in cancer cells with elevated reactive oxygen species levels | The DNA repair function of CUX1 contributes to radioresistance.
Ramdzan ZM, Ginjala V, Pinder JB, Chung D, Donovan CM, Kaur S, Leduy L, Dellaire G, Ganesan S, Nepveu A., Free PMC Article | 09/23/2017 |
| Therefore, we show for the first time that the nuclear localization of Cat L and its substrate Cux1can be positively regulated by Snail NLS and importin beta1, suggesting that Snail, Cat L and Cux1 all utilize importin beta1 for nuclear import. | Snail transcription factor NLS and importin β1 regulate the subcellular localization of Cathepsin L and Cux1.
Burton LJ, Henderson V, Liburd L, Odero-Marah VA., Free PMC Article | 08/26/2017 |
| a positive feedback loop between Snail-nuclear Cat L-CUX1 drives epithelial mesenchymal transition, is reprted. | Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor.
Burton LJ, Dougan J, Jones J, Smith BN, Randle D, Henderson V, Odero-Marah VA., Free PMC Article | 07/15/2017 |