| T-bet deficiency and Hic1 induction override TGF-beta-dependency in the formation of CD103[+] intestine-resident memory CD8[+] T cells. | T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103(+) intestine-resident memory CD8(+) T cells.
Wang L, Mishra S, Fan KK, Quon S, Li G, Yu B, Liao W, Liu Y, Zhang X, Qiu Y, Li Y, Goldrath AW, Ma C, Zhang N., Free PMC Article | 07/25/2024 |
| Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1. | Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.
Hasegawa K, Tamaki M, Sakamaki Y, Wakino S., Free PMC Article | 07/16/2024 |
| HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea. | HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.
Abdul-Aziz D, Hathiramani N, Phung L, Sykopetrites V, Edge ASB., Free PMC Article | 03/5/2022 |
| Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration. | Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
Scott RW, Arostegui M, Schweitzer R, Rossi FMV, Underhill TM., Free PMC Article | 09/19/2020 |
| Loss of HIC1 in KrasG12D/+(Lox-Stop-Lox)/sgHIC1 mice could promote tumorigenesis. | Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression.
Li Y, Yao M, Wu T, Zhang L, Wang Y, Chen L, Fu G, Weng X, Wang J. | 02/29/2020 |
| Loss of Hic1 expression in the early stages of tumor formation may contribute to malignant transformation through the acquisition of chromosomal instability. | The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, Gough DJ, Baylin SB, Burgess A, Cain JE, Watkins DN., Free PMC Article | 03/9/2019 |
| Intestinal innate lymphoid cells express HIC1 in a vitamin A-dependent manner. | HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.
Burrows K, Antignano F, Chenery A, Bramhall M, Korinek V, Underhill TM, Zaph C., Free PMC Article | 07/7/2018 |
| this study identified a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions | The transcriptional repressor HIC1 regulates intestinal immune homeostasis.
Burrows K, Antignano F, Bramhall M, Chenery A, Scheer S, Korinek V, Underhill TM, Zaph C. | 06/2/2018 |
| HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition. | HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
Hao M, Li Y, Wang J, Qin J, Wang Y, Ding Y, Jiang M, Sun X, Zu L, Chang K, Lin G, Du J, Korinek V, Ye DW, Wang J. | 09/23/2017 |
| identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb-like proteins. | Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins.
Boulay G, Dubuissez M, Van Rechem C, Forget A, Helin K, Ayrault O, Leprince D., Free PMC Article | 05/19/2012 |
| Data show that Hic1 expression is absent in polyps from DH mice, with concomitant increased expression of two transcriptional repression targets of Hic1, Sirt1 and Sox9. | Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
Mohammad HP, Zhang W, Prevas HS, Leadem BR, Zhang M, Herman JG, Hooker CM, Watkins DN, Karim B, Huso DL, Baylin SB., Free PMC Article | 08/20/2011 |
| A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. | A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Zhang W, Zeng X, Briggs KJ, Beaty R, Simons B, Chiu Yen RW, Tyler MA, Tsai HC, Ye Y, Gesell GS, Herman JG, Baylin SB, Watkins DN., Free PMC Article | 09/7/2010 |
| For the Hic-1 gene, but not p16, the p53 gene might protect against aberrant methylation. The iNOS gene might not be involved in methylation of the Hic-1 gene, whereas the promoter region of p16 could be prone to methylation in MEFs lacking the iNOS gene. | Lipopolysaccharide induces aberrant hypermethylation of Hic-1 in mouse embryonic fibroblasts lacking p53 gene.
Tatemichi M, Hata H, Tazawa H, Nakadate T. | 01/21/2010 |
| mice disrupted in the germ line for only one allele of Hic1 develop many different spontaneous malignant tumors, including a predominance of epithelial cancers in males and lymphomas and sarcomas in females | Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.
Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB. | 01/21/2010 |
| In human osteosarcomas, hypermethylation of HIC1 is frequent only in tumors with p53 mutation | Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.
Chen W, Cooper TK, Zahnow CA, Overholtzer M, Zhao Z, Ladanyi M, Karp JE, Gokgoz N, Wunder JS, Andrulis IL, Levine AJ, Mankowski JL, Baylin SB. | 01/21/2010 |
| Inactivation of HIC1 results in upregulated SIRT1 expression in normal or cancer cells; this deacetylates and inactivates p53, allowing cells to bypass apoptosis and survive DNA damage. | Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB. | 01/21/2010 |