| Overexpression of Homeobox A1 Relieves Ovalbumin-Induced Asthma in Mice and Is Associated with Blocking of the NF-kappaB Signaling Pathway. | Overexpression of Homeobox A1 Relieves Ovalbumin-Induced Asthma in Mice and Is Associated with Blocking of the NF-κB Signaling Pathway.
Yang J, Hu W, Zhao J. | 03/1/2024 |
| Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish. | Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish.
Odelin G, Faucherre A, Marchese D, Pinard A, Jaouadi H, Le Scouarnec S, FranceGenRef Consortium, Chiarelli R, Achouri Y, Faure E, Herbane M, Théron A, Avierinos JF, Jopling C, Collod-Béroud G, Rezsohazy R, Zaffran S., Free PMC Article | 03/28/2023 |
| miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway. | miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway.
Ding B, Xu S, Sun X, Gao J, Nie W, Xu H. | 08/14/2021 |
| A distal enhancer interacting with the Hoxa1 locus through a long-range chromatin loop. Enhancer deletion significantly inhibited expression of RA-induced Hoxa1 and endoderm master control genes. Hoxa1 directly regulates downstream target genes expression and then orchestrates RA-induced early differentiation of ESCs. | A distal enhancer maintaining Hoxa1 expression orchestrates retinoic acid-induced early ESCs differentiation.
Su G, Guo D, Chen J, Liu M, Zheng J, Wang W, Zhao X, Yin Q, Zhang L, Zhao Z, Shi J, Lu W., Free PMC Article | 01/11/2020 |
| we provide evidence that HOXA1 displays an unexpectedly long half-life and demonstrate that PRDM14 can reduce the stability and affect the transcriptional activity of HOXA1. | PRDM14, a putative histone methyl-transferase, interacts with and decreases the stability and activity of the HOXA1 transcription factor.
Draime A, Bridoux L, Belpaire M, Pringels T, Tys J, Rezsohazy R. | 07/14/2018 |
| Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions.This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins | HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets.
De Kumar B, Parker HJ, Paulson A, Parrish ME, Pushel I, Singh NP, Zhang Y, Slaughter BD, Unruh JR, Florens L, Zeitlinger J, Krumlauf R., Free PMC Article | 05/5/2018 |
| Hoxa1 and Hoxb1 are required for pharyngeal arch artery development. | Hoxa1 and Hoxb1 are required for pharyngeal arch artery development.
Roux M, Laforest B, Eudes N, Bertrand N, Stefanovic S, Zaffran S. | 12/30/2017 |
| Authors found evidence for a high degree of evolutionary conservation of many binding regions and downstream targets of Hoxa1 between mouse and zebrafish. | Hoxa1 targets signaling pathways during neural differentiation of ES cells and mouse embryogenesis.
De Kumar B, Parker HJ, Paulson A, Parrish ME, Zeitlinger J, Krumlauf R. | 12/23/2017 |
| Data indicate that homeobox A1 (HOXA1) was a direct microRNA miR-30b target in esophageal cancer (EC) cells. | miR-30b inhibits cancer cell growth, migration, and invasion by targeting homeobox A1 in esophageal cancer.
Li Q, Zhang X, Li N, Liu Q, Chen D. | 06/24/2017 |
| In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5, HoxC4 &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin down regulates HoxA10. T3 results in over expression of HoxA5, HoxC4 and HoxC8 genes, whereas insulin up regulates expression of only HoxC8 | Fat accumulation in differentiated brown adipocytes is linked with expression of Hox genes.
Singh S, Rajput YS, Barui AK, Sharma R, Datta TK. | 06/3/2017 |
| These data suggest that Hoxb1 and Hoxa1 are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy | Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice.
Ruff JS, Saffarini RB, Ramoz LL, Morrison LC, Baker S, Laverty SM, Tvrdik P, Potts WK., Free PMC Article | 07/16/2016 |
| YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages. | YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues.
Liu M, Zhao S, Lin Q, Wang XP., Free PMC Article | 06/6/2015 |
| Many Hoxa1 interactors are proteins involved in cell-signaling transduction, cell adhesion and vesicular trafficking. | Protein interactions of the transcription factor Hoxa1.
Lambert B, Vandeputte J, Remacle S, Bergiers I, Simonis N, Twizere JC, Vidal M, Rezsohazy R., Free PMC Article | 02/16/2013 |
| Hoxa1 null mice show defects such as interrupted aortic arch, aberrant subclavian artery and Tetralogy of Fallot mimic the defects in HoxA1 syndrome patients. | Cardiovascular defects in a mouse model of HOXA1 syndrome.
Makki N, Capecchi MR., Free PMC Article | 04/7/2012 |
| Hoxa1 acts in a genetic cascade upstream of genes controlling specific aspects of embryonic development. | Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.
Makki N, Capecchi MR., Free PMC Article | 10/29/2011 |
| Hoxa1 lineage tracing uncovered new domains of Hoxa1 expression in rhombomere 3, the otic epithelium, and cardiac precursors, suggesting a more direct role for Hoxa1 in development of these tissues than previously believed. | Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere.
Makki N, Capecchi MR., Free PMC Article | 05/31/2010 |
| Hoxa1-399 reduces Hoxa1-993/Pbx1 binding to the Hoxb1 SOct-R3 region | The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells.
Fernandez CC, Gudas LJ., Free PMC Article | 01/21/2010 |
| Hoxa1 activity is essential for the neuronal differentiation of embryonic stem cells | Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons.
Martinez-Ceballos E, Gudas LJ. | 01/21/2010 |
| The newly generated autoregulatory Hoxa1 gene can deliver the functionality of both paralogs in these mice, providing normal viability as well as proper facial nerve formation even in the Hoxb1 mutant background. | Reversal of Hox1 gene subfunctionalization in the mouse.
Tvrdik P, Capecchi MR. | 01/21/2010 |
| results describe the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2 | Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes.
Gavalas A, Ruhrberg C, Livet J, Henderson CE, Krumlauf R. | 01/21/2010 |
| HOXA1 is a mammary epithelial oncogene with aggressive in vivo tumor formation | Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene.
Zhang X, Zhu T, Chen Y, Mertani HC, Lee KO, Lobie PE. | 01/21/2010 |
| mediates repression of endodermal differentiation while promoting expression of ectodermal and mesodermal characteristics | Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal.
Martinez-Ceballos E, Chambon P, Gudas LJ. | 01/21/2010 |
| Plays a vital role in the generation of neural crest cells. | Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.
Gavalas A, Trainor P, Ariza-McNaughton L, Krumlauf R. | 01/12/2004 |