| Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain. | Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
Sugasini D, Yang P, Ng D, Khetarpal SA, Vitali C, Rader DJ, Subbaiah PV., Free PMC Article | 11/27/2021 |
| The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas. | Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin β-Receptor pathway.
Andrés-Blasco I, Vinué Á, Herrero-Cervera A, Martínez-Hervás S, Nuñez L, Piqueras L, Ascaso JF, Sanz MJ, Burks DJ, González-Navarro H. | 01/20/2018 |
| hepatic lipase KO mice had dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. Also glucose intolerance, pancreatic and hepatic inflammation and steatosis. | Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis.
Andrés-Blasco I, Herrero-Cervera A, Vinué Á, Martínez-Hervás S, Piqueras L, Sanz MJ, Burks DJ, González-Navarro H. | 02/6/2016 |
| Bone marrow (BM)-derived hepatic lipase mitigates the HDL-lowering, HDL-modulating, and cholesterol-raising effects of BM-derived cholesteryl ester transfer protein. | Bone marrow-derived HL mitigates bone marrow-derived CETP-mediated decreases in HDL in mice globally deficient in HL and the LDLr.
Hime NJ, Black AS, Bonnet DJ, Curtiss LK., Free PMC Article | 11/14/2015 |
| HL expressed by osteoblasts has an impact on osteoblast OPG expression and that lack of HL leads to increased bone mass. | Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity.
Bartelt A, Beil FT, Müller B, Koehne T, Yorgan TA, Heine M, Yilmaz T, Rüther W, Heeren J, Schinke T, Niemeier A. | 05/23/2015 |
| Hepatic lipase and endothelial lipase influence molecular species of several classes of plasma lipids. | Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.
Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ., Free PMC Article | 01/10/2015 |
| interaction of LIGHT with LTbetaR on hepatocytes, but not Kupffer cells, is sufficient to down regulate hepatic lipase expression and that this effect can be independent of LIGHT's costimulatory function. | LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells.
Chellan B, Koroleva EP, Sontag TJ, Tumanov AV, Fu YX, Getz GS, Reardon CA., Free PMC Article | 06/29/2013 |
| Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. | Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
Escolà-Gil JC, Chen X, Julve J, Quesada H, Santos D, Metso J, Tous M, Jauhiainen M, Blanco-Vaca F. | 06/15/2013 |
| Data show a novel pathway involving HL hydrolysis of VLDL that activates PPARdelta through generation of specific monounsaturated fatty acids. | VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses.
Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J., Free PMC Article | 12/31/2011 |
| These results demonstrated that fatty acid synthase and hepatic lipase might be FXR-regulated genes in liver cells. | Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase.
Shen LL, Liu H, Peng J, Gan L, Lu L, Zhang Q, Li L, He F, Jiang Y. | 03/26/2011 |
| The additive effect of hepatic lipase and endothelial lipase on HDL metabolism but not macrophage reverse cholesterol transport in mice. | Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.
Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ., Free PMC Article | 09/20/2010 |
| highly divergent effects of naturally occurring HL coding sequence variants on lipid and lipoprotein metabolism | Mouse hepatic lipase alleles with variable effects on lipoprotein composition and size.
Pratt SM, Chiu S, Espinal GM, Shibata NM, Wong H, Warden CH., Free PMC Article | 07/12/2010 |
| HL deficiency protects against diet-induced obesity and its hepatic sequelae. | Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis.
Chiu HK, Qian K, Ogimoto K, Morton GJ, Wisse BE, Agrawal N, McDonald TO, Schwartz MW, Dichek HL., Free PMC Article | 03/29/2010 |
| Elevated PLTP activity lowers plasma HDL-cholesterol by stimulating the plasma turnover and hepatic uptake of HDL cholesteryl esters. | Novel roles of hepatic lipase and phospholipid transfer protein in VLDL as well as HDL metabolism.
van Haperen R, Samyn H, van Gent T, Zonneveld AJ, Moerland M, Grosveld F, Jansen H, Dallinga-Thie GM, van Tol A, de Crom R. | 01/21/2010 |
| ciHL expression reduces atherosclerosis | Reduced atherosclerosis in chow-fed mice expressing high levels of a catalytically inactive human hepatic lipase.
Qian K, Agrawal N, Dichek HL. | 01/21/2010 |
| The results demonstrate that hepatic lipase deficiency, like LDLR deficiency, blunts the adrenal response to chronic ACTH stimulation and suggest a novel role for hepatic lipase in adrenal physiology. | Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology.
Dichek HL, Agrawal N, El Andaloussi N, Qian K. | 01/21/2010 |
| Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. | Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice.
Nong Z, Gonzalez-Navarro H, Amar M, Freeman L, Knapper C, Neufeld EB, Paigen BJ, Hoyt RF, Fruchart-Najib J, Santamarina-Fojo S., Free PMC Article | 01/21/2010 |
| the determinants of cell surface binding exist within the carboxyl terminal 70 amino acids of hepatic lipase, of which the last five residues play an important role | The amino acid sequences of the carboxyl termini of human and mouse hepatic lipase influence cell surface association.
Brown RJ, Schultz JR, Ko KW, Hill JS, Ramsamy TA, White AL, Sparks DL, Yao Z. | 01/21/2010 |
| hepatic lipase activity is influenced by epistatic interaction between two nonstructural loci on chromosomes 7 and 3 | Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice.
Yi N, Chiu S, Allison DB, Fisler JS, Warden CH. | 01/21/2010 |
| findings indicate that hepatic lipase is required for optimal reproductive performance | Hepatic lipase deficiency attenuates mouse ovarian progesterone production leading to decreased ovulation and reduced litter size.
Wade RL, Van Andel RA, Rice SG, Banka CL, Dyer CA. | 01/21/2010 |
| Establishment of an antiatherogenic role of the ligand-binding function of hepataic lipase in LDL receptor-deficient mice. | Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice.
Freeman L, Amar MJ, Shamburek R, Paigen B, Brewer HB Jr, Santamarina-Fojo S, González-Navarro H. | 01/21/2010 |
| HL-deficiency delays the onset and/or progression of atherosclerosis via a SR-BI-independent mechanism | Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice.
Karackattu SL, Trigatti B, Krieger M. | 01/21/2010 |
| synthesized in peritoneal macrophages | Identification of mouse and human macrophages as a site of synthesis of hepatic lipase.
González-Navarro H, Nong Z, Freeman L, Bensadoun A, Peterson K, Santamarina-Fojo S. | 01/21/2010 |
| indicate a role for hepatic lipase in clearing phospholipase/free cholesterol from the vesicular lipoproteins of phospholipid transfer protein knock out mice. | Role of hepatic lipase and scavenger receptor BI in clearing phospholipid/free cholesterol-rich lipoproteins in PLTP-deficient mice.
Kawano K, Qin S, Vieu C, Collet X, Jiang XC. | 01/21/2010 |
| Not essential for diet-induced gallstone formation in mice. | Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice.
Amigo L, Mardones P, Ferrada C, Zanlungo S, Nervi F, Miquel JF, Rigotti A. | 01/21/2010 |