| Brainstem serotonin neurons selectively gate retinal information flow to thalamus. | Brainstem serotonin neurons selectively gate retinal information flow to thalamus.
Reggiani JDS, Jiang Q, Barbini M, Lutas A, Liang L, Fernando J, Deng F, Wan J, Li Y, Chen C, Andermann ML., Free PMC Article | 03/8/2023 |
| Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice. | Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice.
Oliver BL, Burdette MH, Pahua AE, Cavazos C, Morales CA, Alvarez BD, Amodeo DA. | 04/23/2022 |
| Depressive-like state sensitizes 5-HT1A and 5-HT1B auto-receptors in the dorsal raphe nucleus sub-system. | Depressive-like state sensitizes 5-HT(1A) and 5-HT(1B) auto-receptors in the dorsal raphe nucleus sub-system.
Li X, Sun X, Sun J, Zu Y, Zhao S, Sun X, Li L, Zhang X, Wang W, Liang Y, Wang W, Liang X, Sun C, Guan X, Tang M. | 05/8/2021 |
| Consistent with previous studies that have optogenetically inhibited vHPC-mPFC projections, activating prefrontal 5-HT1B receptors suppressed theta-frequency mPFC activity (4-12 Hz), and reduced avoidance of anxiogenic regions in the elevated plus maze | Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs.
Kjaerby C, Athilingam J, Robinson SE, Iafrati J, Sohal VS., Free PMC Article | 12/2/2017 |
| we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes. | Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.
Ishikawa C, Li H, Ogura R, Yoshimura Y, Kudo T, Shirakawa M, Shiba D, Takahashi S, Morita H, Shiga T., Free PMC Article | 09/16/2017 |
| Mice lacking 5-HT1B autoreceptors displayed the expected increases in extracellular serotonin levels in the ventral hippocampus following administration of a selective serotonin reuptake inhibitor. | A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.
Nautiyal KM, Tritschler L, Ahmari SE, David DJ, Gardier AM, Hen R., Free PMC Article | 09/16/2017 |
| 5-HT1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in pulmonary arterial hypertension. | Serotonin Signaling Through the 5-HT(1B) Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension.
Hood KY, Mair KM, Harvey AP, Montezano AC, Touyz RM, MacLean MR., Free PMC Article | 07/15/2017 |
| Data suggest that pharmacological stimulation of serotonin 5Ht1b receptor enhances up-regulation of plasma Glp1 (glucagon-like peptide 1) induced by Dpp4 (dipeptidylpeptidase 4) inhibition independently of feeding and also improves glucose tolerance. | Pharmacological stimulation of serotonin 5-HT1B receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice.
Nonogaki K, Kaji T. | 08/27/2016 |
| 5-HT1B Knockout and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in dopamine transporter Knockout mice. | Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout.
Hall FS, Sora I, Hen R, Uhl GR., Free PMC Article | 02/6/2016 |
| 5-HT1BR was validated as a target for miRNA-96. Transfection of precursor miRNA-96 into hPASMCs reduced 5-HT1BR expression and inhibited serotonin-induced proliferation in pulmonary hypertension development. | A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension.
Wallace E, Morrell NW, Yang XD, Long L, Stevens H, Nilsen M, Loughlin L, Mair KM, Baker AH, MacLean MR., Free PMC Article | 09/5/2015 |
| The data of this study showed that while adolescent expression of 5-HT1BRs influences aggressive behavior, a distinct set of 5-HT1B receptors modulates impulsive behavior during adulthood. | Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity.
Nautiyal KM, Tanaka KF, Barr MM, Tritschler L, Le Dantec Y, David DJ, Gardier AM, Blanco C, Hen R, Ahmari SE., Free PMC Article | 07/25/2015 |
| The serotoninergic system plays an important role in the regulation of stress-induced depigmentation, which can be mediated by 5-HT1A/1B receptors. | 5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress.
Wu HL, Pang SL, Liu QZ, Wang Q, Cai MX, Shang J., Free PMC Article | 11/8/2014 |
| 5-HT(1B)R stimulation increased glutamatergic neurotransmission in the hippocampus in p11KO mice, but not in WT mice. Hippocampal p11 determines the directionality of 5-HT(1B)R action on emotional memory processing | Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.
Eriksson TM, Alvarsson A, Stan TL, Zhang X, Hascup KN, Hascup ER, Kehr J, Gerhardt GA, Warner-Schmidt J, Arango-Lievano M, Kaplitt MG, Ogren SO, Greengard P, Svenningsson P., Free PMC Article | 05/31/2014 |
| Selective inhibition of 5-HT2A by sarpogrelate stimulated angiogenesis, restoring ischemic limb blood perfusion in a severe diabetic mouse model through stimulation of the eNOS/Akt pathway via the endothelial 5-HT1B receptor. | Role of serotonin in angiogenesis: induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice.
Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Kusunoki H, Chatterjee A, Okayama K, Rakugi H, Morishita R. | 05/26/2012 |
| Data from double knockout mouse model indicate that deletion of both HTR1A and HTR1B induces anxiety-like behavioral state associated with increased 5HT neurotransmission; mice also exhibit reduced body temperature regulation when exposed to stress. | Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments.
Guilloux JP, David DJ, Xia L, Nguyen HT, Rainer Q, Guiard BP, Repérant C, Deltheil T, Toth M, Hen R, Gardier AM. | 10/15/2011 |
| Data indicate that most p11 expressing cells in cerebral cortex, hippocampus, cerebellum, & caudate-putamen express HTR1B or co-express HTR1B/HTR4, suggesting crucial role for p11 in modulating actions of serotonin via these receptor subtypes. | Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum.
Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. | 10/15/2011 |
| Decreased cell size and increased intracellular serotonin level were observed in the case of monoamine oxidase A deficiency, while excessive cell size and decreased intracellular serotonin level were observed in the case of autoreceptor deficiency. | [Development of serotonergic neurons of dorsal raphe nuclei in mice with knockout of monoamine oxidase A and 5-HT1A and 5-HT1B autoreceptor].
Urtikova NA, Sapronova AIa, Brisorgueil MJ, Verge D, Ugriumov MV. | 01/21/2010 |
| Depression of preclinical Huntington's disease corresponded with specific increases in hippocampal htr1A and htr1B expression and cortical htr2C expression. | Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease.
Pang TY, Du X, Zajac MS, Howard ML, Hannan AJ. | 01/21/2010 |
| These results suggest that 5-HT(1B) receptors in the mPFC may serve to selectively disinhibit aggressive behavior in mice with a history of Alc self-administration. | Escalated aggression after alcohol drinking in male mice: dorsal raphé and prefrontal cortex serotonin and 5-HT(1B) receptors.
Faccidomo S, Bannai M, Miczek KA. | 01/21/2010 |
| These results show that a prenatal 5-HT excess affects, via the overactivation of 5-HT(2A)-R, the expression of 5-HT(1B)-R in phrenic motor neurons and the organization of their premotor network. | Prenatal activation of 5-HT2A receptor induces expression of 5-HT1B receptor in phrenic motoneurons and alters the organization of their premotor network in newborn mice.
Bras H, Gaytán SP, Portalier P, Zanella S, Pásaro R, Coulon P, Hilaire G. | 01/21/2010 |
| Increases in D2 binding sites, presumably involving GABAergic projection neurons, were measured in the nucleus accumbens, olfactory tubercle and ventral tegmental area of the 5-HT1B KO. | Regionally selective changes in neurotransmitter receptors in the brain of the 5-HT1B knockout mouse.
Ase AR, Reader TA, Hen R, Descarries L. | 01/21/2010 |
| is a neurochemical basis for the behavioral sensitization. | [Involvement of prefrontal serotonergic neurons in methamphetamine-induced behavioral sensitization].
Ago Y, Nakamura S, Arikawa S, Yata M, Matsuda T. | 01/21/2010 |
| Early-weaned mice were more aggressive after food restriction stress than were the normally weaned mice and had lower 5HT1B expression. | Changes in social instigation- and food restriction-induced aggressive behaviors and hippocampal 5HT1B mRNA receptor expression in male mice from early weaning.
Nakamura K, Kikusui T, Takeuchi Y, Mori Y. | 01/21/2010 |
| Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. | Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity.
Sibille E, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso C, Tseng GC, Pezzone M, Hen R, Belzung C., Free PMC Article | 01/21/2010 |
| results of the present study indicate that the dynamic modulation of 5-HT1B receptor function by p11 may be involved in molecular adaptations occurring in neuronal networks that are dysfunctional in depression-like states | Alterations in 5-HT1B receptor function by p11 in depression-like states.
Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P. | 01/21/2010 |