| The Role of CDCA2 in tumor genesis, prognosis and future treatments. | The Role of CDCA2 in tumor genesis, prognosis and future treatments.
Lin X, Zou Z, Zhong J, Wang T, Ma W, Hu T, Sun W, Xu Y, Eggermont AMM, Chen Y. | 10/4/2024 |
| A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma. | A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.
Li W, Lv D, Yao J, Chen B, Liu H, Li W, Xu C, Li Z., Free PMC Article | 09/26/2023 |
| CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A. | CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A.
Sun W, Jin Y, Wei C, Xu Y, Liu W, Zhong J, Zou Z, Lin X, Xiang Y, Chen Y. | 06/25/2023 |
| PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma. | PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma.
Xiao F, Jie X, Zhou X, Guo Y, Sun GF, Lin L, Hu GW, Huang K, Guo H., Free PMC Article | 05/8/2023 |
| Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner. | Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner.
Wang J, Liu X, Chu H, Chen J., Free PMC Article | 02/10/2023 |
| CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway. | CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway.
Li K, Fan T, Shi Z, Jiang H., Free PMC Article | 01/11/2023 |
| Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation. | Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation.
Huguet F, Gokan E, Foster HA, Amin HA, Vagnarelli P., Free PMC Article | 04/30/2022 |
| CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma. | CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.
Wang S, Cao K, Liao Y, Zhang W, Zheng J, Li X, Huang M, Zhong Y, Hu X, Chen D, Wang Y. | 12/25/2021 |
| RepoMan stimulates the chromosome-dependent pathway of microtubule assembly. | RepoMan stimulates the chromosome-dependent pathway of microtubule assembly.
De Munter S, Van der Hoeven G, Bollen M., Free PMC Article | 12/4/2021 |
| CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells. | CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells.
Xu B, Chen H, Xu Z, Yao X, Sun X, Cheng H., Free PMC Article | 10/16/2021 |
| CDCA2 promotes proliferation and migration of melanoma by upregulating CCAD1. | CDCA2 promotes proliferation and migration of melanoma by upregulating CCAD1.
Jin WH, Zhou AT, Chen JJ, Cen Y. | 05/8/2021 |
| Aurora B regulates PP1gamma-Repo-Man interactions to maintain the chromosome condensation state. | Aurora B regulates PP1γ-Repo-Man interactions to maintain the chromosome condensation state.
Xin G, Fu J, Luo J, Deng Z, Jiang Q, Zhang C., Free PMC Article | 03/13/2021 |
| Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells. | Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells.
Manzione MG, Rombouts J, Steklov M, Pasquali L, Sablina A, Gelens L, Qian J, Bollen M., Free PMC Article | 01/23/2021 |
| this study shows that CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo | CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo.
Feng Y, Qian W, Zhang Y, Peng W, Li J, Gu Q, Ji D, Zhang Z, Wang Q, Zhang D, Sun Y., Free PMC Article | 12/28/2019 |
| The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A. | p37/UBXN2B regulates spindle orientation by limiting cortical NuMA recruitment via PP1/Repo-Man.
Lee BH, Schwager F, Meraldi P, Gotta M., Free PMC Article | 12/22/2018 |
| Repo-Man/PP1 regulates the formation of heterochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein 1 binding and H3K27me3 recruitment. | Repo-Man/PP1 regulates heterochromatin formation in interphase.
de Castro IJ, Budzak J, Di Giacinto ML, Ligammari L, Gokhan E, Spanos C, Moralli D, Richardson C, de Las Heras JI, Salatino S, Schirmer EC, Ullman KS, Bickmore WA, Green C, Rappsilber J, Lamble S, Goldberg MW, Vinciotti V, Vagnarelli P., Free PMC Article | 11/17/2018 |
| Here the authors show how Ki-67 and RepoMan form mitotic exit phosphatases by recruiting PP1, how they distinguish between distinct PP1 isoforms and how the assembly of these two holoenzymes are dynamically regulated by Aurora B kinase during mitosis. | The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.
Kumar GS, Gokhan E, De Munter S, Bollen M, Vagnarelli P, Peti W, Page R., Free PMC Article | 11/4/2017 |
| Inhibition of cell division cycle associated 2 (CDCA2) suppressed the proliferation of lung adenocarcinoma (LAC) cells via G1 phase arrest by downregulating cyclin E1(CCNE1), while overexpression of CDCA2 promoted LAC cells proliferation by upregulating CCNE1. | CDCA2 promotes lung adenocarcinoma cell proliferation and predicts poor survival in lung adenocarcinoma patients.
Shi R, Zhang C, Wu Y, Wang X, Sun Q, Sun J, Xia W, Dong G, Wang A, Jiang F, Xu L., Free PMC Article | 09/2/2017 |
| Results report that BubR1 and RepoMan bind directly to PP2A-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser residue enhances binding. RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions. | Expanding the PP2A Interactome by Defining a B56-Specific SLiM.
Wang X, Bajaj R, Bollen M, Peti W, Page R., Free PMC Article | 07/1/2017 |
| Aurora B phosphorylates Repo-Man at S893, preventing its recruitment by histones. | Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man.
Qian J, Beullens M, Lesage B, Bollen M. | 02/8/2014 |
| Proteomic identification of a large number of novel RepoMan interactors. | Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase).
Prévost M, Chamousset D, Nasa I, Freele E, Morrice N, Moorhead G, Trinkle-Mulcahy L., Free PMC Article | 12/14/2013 |
| Data indicate that CDCA2 frequently is overexpressed in oral squamous cell carcinoma (OSCC) and might be associated with OSCC progression by preventing cell-cycle arrest and apoptosis. | Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.
Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H., Free PMC Article | 08/31/2013 |
| It was shown that Repo-Man and Sds22 contribute to timely Aurora B kinase substrate dephosphorylation on anaphase chromatin. | Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.
Wurzenberger C, Held M, Lampson MA, Poser I, Hyman AA, Gerlich DW., Free PMC Article | 10/20/2012 |
| This study demonistrated that identify Repo-Man as a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit. | Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit.
Vagnarelli P, Ribeiro S, Sennels L, Sanchez-Pulido L, de Lima Alves F, Verheyen T, Kelly DA, Ponting CP, Rappsilber J, Earnshaw WC., Free PMC Article | 10/15/2011 |
| Repo-Man promotes H3T11ph dephosphorylation by an indirect mechanism but directly and specifically targets H3T3ph for dephosphorylation by associated PP1gamma. | PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting.
Qian J, Lesage B, Beullens M, Van Eynde A, Bollen M. | 09/10/2011 |