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    LRATD2 LRAT domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 157638, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    FAM84B promotes breast cancer tumorigenesis through activation of the NF-kappaB and death receptor signaling pathways.

    FAM84B promotes breast cancer tumorigenesis through activation of the NF-κB and death receptor signaling pathways.
    Zhang Y, Yang F.

    09/28/2023
    FAM84B promotes the proliferation of glioma cells through the cell cycle pathways.

    FAM84B promotes the proliferation of glioma cells through the cell cycle pathways.
    Ren D, Zhuang X, Lv Y, Zhang Y, Xu J, Gao F, Chen D, Wang Y., Free PMC Article

    12/3/2022
    FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK-3beta/beta-catenin pathway.

    FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK-3β/β-catenin pathway.
    Wang M, Li C, Shi W.

    01/8/2022
    Identification of Hub Genes in Gastric Cancer with High Heterogeneity Based on Weighted Gene Co-Expression Network.

    Identification of Hub Genes in Gastric Cancer with High Heterogeneity Based on Weighted Gene Co-Expression Network.
    Dong Z, Pei S, Zhao Y, Guo S, Wang Y.

    07/10/2021
    FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/beta-catenin pathway.

    FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/β-catenin pathway.
    Zhang X, Xu J, Yan R, Zhang Y, Hu Z, Fu H, You Q, Cai Q, Yang D., Free PMC Article

    02/27/2021
    The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert.

    The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert.
    Gu Y, Lin X, Kapoor A, Chow MJ, Jiang Y, Zhao K, Tang D., Free PMC Article

    02/2/2021
    non-coding RNA (lncRNA) FAM84B-AS promotes resistance of Gastric Cancer to platinum drugs through inhibition of FAM84B expression.

    Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
    Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, Xu J.

    11/9/2019
    High FAM84B expression is associated with prostate cancer progression.

    Upregulation of FAM84B during prostate cancer progression.
    Wong N, Gu Y, Kapoor A, Lin X, Ojo D, Wei F, Yan J, de Melo J, Major P, Wood G, Aziz T, Cutz JC, Bonert M, Patterson AJ, Tang D., Free PMC Article

    10/7/2017
    Data suggest that FAM84B protein and the NOTCH pathway are involved in the progression of esophageal squamous cell carcinoma (ESCC) and may be potential diagnostic targets for ESCC susceptibility.

    Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma.
    Cheng C, Cui H, Zhang L, Jia Z, Song B, Wang F, Li Y, Liu J, Kong P, Shi R, Bi Y, Yang B, Wang J, Zhao Z, Zhang Y, Hu X, Yang J, He C, Zhao Z, Wang J, Xi Y, Xu E, Li G, Guo S, Chen Y, Yang X, Chen X, Liang J, Guo J, Cheng X, Wang C, Zhan Q, Cui Y., Free PMC Article

    10/22/2016
    We demonstrated the decreased of circulating FAM84B mRNA and protein after neoadjuvant CRT may predict pCR, and FAM84B protein is overexpressed in ESCC.

    Circulating mRNA Profiling in Esophageal Squamous Cell Carcinoma Identifies FAM84B As A Biomarker In Predicting Pathological Response to Neoadjuvant Chemoradiation.
    Hsu FM, Cheng JC, Chang YL, Lee JM, Koong AC, Chuang EY., Free PMC Article

    03/5/2016
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.
    White KL, Sellers TA, Fridley BL, Vierkant RA, Phelan CM, Tsai YY, Kalli KR, Berchuck A, Iversen ES, Hartmann LC, Liebow M, Armasu S, Fredericksen Z, Larson MC, Duggan D, Couch FJ, Schildkraut JM, Cunningham JM, Goode EL.

    Evaluation of the 8q24 prostate cancer risk locus and MYC expression.
    Pomerantz MM, Beckwith CA, Regan MM, Wyman SK, Petrovics G, Chen Y, Hawksworth DJ, Schumacher FR, Mucci L, Penney KL, Stampfer MJ, Chan JA, Ardlie KG, Fritz BR, Parkin RK, Lin DW, Dyke M, Herman P, Lee S, Oh WK, Kantoff PW, Tewari M, McLeod DG, Srivastava S, Freedman ML.

    08/12/2009
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