| In this article, we reviewed the findings in IEX-1 knockout mice from our laboratory and others and primarily focused on the roles of IEX-1 in cardiovascular and metabolic dis | Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases.
Shahid M, Hermes EL, Chandra D, Tauseef M, Siddiqui MR, Faridi MH, Wu MX., Free PMC Article | 11/30/2019 |
| IER3 expression is blunted during heart failure development in a titin-deficient mouse model. | Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy.
Zhou Q, Hahn JK, Neupane B, Aidery P, Labeit S, Gawaz M, Gramlich M., Free PMC Article | 04/29/2017 |
| these results indicate that IER3 is a key player in expanding the pool of APC while highlighting the role of distinct effectors found in an obese microenvironment in this process | IER3 Promotes Expansion of Adipose Progenitor Cells in Response to Changes in Distinct Microenvironmental Effectors.
Ravaud C, Esteve D, Villageois P, Bouloumie A, Dani C, Ladoux A. | 04/9/2016 |
| Loss of IEX-1 results in reduced VNH accompanied with a decrease in proliferation, reduced fibroblast, myofibroblast, and Ly6C staining accompanied with increased apoptosis mediated through a reduction in Vegf-A/Mcp-1 axis and Mmp-9. | The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula.
Brahmbhatt A, NievesTorres E, Yang B, Edwards WD, Roy Chaudhury P, Lee MK, Kong H, Mukhopadhyay D, Kumar R, Misra S., Free PMC Article | 12/5/2015 |
| IER3 supports KRASG12D-associated oncogenesis in the pancreas by sustaining ERK1/2 phosphorylation via phosphatase PP2A inhibition. | IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.
Garcia MN, Grasso D, Lopez-Millan MB, Hamidi T, Loncle C, Tomasini R, Lomberk G, Porteu F, Urrutia R, Iovanna JL., Free PMC Article | 03/7/2015 |
| Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3). | Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3).
Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX., Free PMC Article | 07/26/2014 |
| the interference of IER3 with the PI3K/Akt-Fyn pathway represents a novel mechanism of Nrf2 regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity. | Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
Stachel I, Geismann C, Aden K, Deisinger F, Rosenstiel P, Schreiber S, Sebens S, Arlt A, Schäfer H., Free PMC Article | 03/29/2014 |
| IEX-1 has a role in activation of Erk and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells | Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
de Laval B, Pawlikowska P, Barbieri D, Besnard-Guerin C, Cico A, Kumar R, Gaudry M, Baud V, Porteu F., Free PMC Article | 03/22/2014 |
| Data suggest a role for the immediate early response gene X-1 (IEX-1) in the control of colon epithelial homeostasis. | IEX-1 deficiency protects against colonic cancer.
Ustyugova IV, Zhi L, Abramowitz J, Birnbaumer L, Wu MX., Free PMC Article | 11/3/2012 |
| Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 cells | Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling.
Zhi L, Ustyugova IV, Chen X, Zhang Q, Wu MX., Free PMC Article | 10/20/2012 |
| IER3 plays a complex and to some extent contradictory role in cell cycle control and apoptosis. Effects of IER3 relate to an interference with certain signalling pathways | Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis.
Arlt A, Schäfer H. | 10/1/2011 |
| Mcl-1 translocation to the nucleus is a general response to genotoxic stress that is strictly and timely controlled by IEX-1 in response to DNA damage. Loss of IEX-1 leads to genomic instability. | ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response.
Pawlikowska P, Leray I, de Laval B, Guihard S, Kumar R, Rosselli F, Porteu F., Free PMC Article | 03/26/2011 |
| Null mutation of IEX-1 enhances the susceptibility of deficient mice to Leishmania major infection and aggravates inflammatory responses in comparison with wild-type control mice. | Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1.
Akilov OE, Ustyugova IV, Zhi L, Hasan T, Wu MX. | 02/15/2010 |
| The study reveals that IEX-1 targets the mitochondrial F1Fo-ATPase Inhibitor (IF1) for degradation, resulting in acceleration of ATP hydrolysis, concomitant with reduction in ROS production. | IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation.
Shen L, Zhi L, Hu W, Wu MX., Free PMC Article | 01/21/2010 |
| T-cell lymphomas develop in emu-IEX-1 mice. | Development of T-cell lymphomas in Emu-IEX-1 mice.
Zhang Y, Finegold MJ, Porteu F, Kanteti P, Wu MX. | 01/21/2010 |
| IEX-1 has roles in regulation of cell death and oncogenesis [review] | Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis.
Wu MX. | 01/21/2010 |