| ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19 phosphorylation and phosphatidylinositol 3-kinase (PI3K) signals. | Igβ ubiquitination activates PI3K signals required for endosomal sorting.
Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O'Neill SK, Wilson P, Sciammas R, Clark MR., Free PMC Article | 12/23/2017 |
| B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis. | B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis.
Brühl H, Cihak J, Talke Y, Rodriguez Gomez M, Hermann F, Goebel N, Renner K, Plachý J, Stangassinger M, Aschermann S, Nimmerjahn F, Mack M. | 05/9/2015 |
| Data indicate that in the absence of DGKzeta, the threshold for B cell antigen receptor (BCR) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK) pathway, was markedly reduced in mature follicular B cells. | Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL., Free PMC Article | 06/7/2014 |
| The cytoplasmic tail of IgG1 is strictly required for the surface expression of IgG1 when the expression of Iga/Igb heterodimer is down-regulated in B lymphoma. | IgG1 cytoplasmic tail is essential for cell surface expression in Igβ down-regulated cells.
Todo K, Koga O, Nishikawa M, Hikida M. | 05/10/2014 |
| endocytosed BCR sequentially regulates MAPK and Akt signaling pathways from intracellular compartments | Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments.
Chaturvedi A, Martz R, Dorward D, Waisberg M, Pierce SK., Free PMC Article | 12/17/2011 |
| Data indicate that both the Igalpha and the Igbeta cytoplasmic domains alone are sufficient for trafficking to lysosomal compartments, and are unaffected by mutation of 4 amino acid residues within their respective ITAMs. | The role of Ig-α/β in B cell antigen receptor internalization.
Jang C, Machtaler S, Matsuuchi L. | 03/5/2011 |
| describe a novel mouse with a spontaneous mutation in the Cd79b gene leading to a block in B-cell development and agammaglobulinemia. | Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage.
Shulzhenko N, Morgun A, Matzinger P, Shulzhenko N, Morgun A, Matzinger P., Free PMC Articles: PMC2787784, PMC2787784 | 01/21/2010 |
| Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage | Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage.
Shulzhenko N, Morgun A, Matzinger P, Shulzhenko N, Morgun A, Matzinger P., Free PMC Articles: PMC2787784, PMC2787784 | 09/15/2009 |
| MHC II structural requirements for mediation of cell death signaling in a murine B cell lymphoma with Igalpha/beta | MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death.
Jin L, Stolpa JC, Young RM, Pugh-Bernard AE, Refaeli Y, Cambier JC., Free PMC Article | 01/21/2010 |
| Deletion in developing B cells leads to cell death; Igbeta expression is essential to maintain preB cell and immature B cell survival and to mediate B cell differentiation | Deletion of immunoglobulin beta in developing B cells leads to cell death.
Meffre E, Nussenzweig MC., Free PMC Article | 01/21/2010 |
| The VHDJH recombination process at the IgH locus and the survival of pro-B cells that carry these rearrangements do not depend on the expression of Ig-beta molecules. | B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.
Pelanda R, Braun U, Hobeika E, Nussenzweig MC, Reth M. | 01/21/2010 |
| gamma1 chain can exert a unique signaling function that can partially replace that of the Ig alpha/beta heterodimer in B cell maintenance and may contribute to memory B cell physiology | IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.
Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, Sasaki Y, Classen S, Lutz C, Brombacher F, Nitschke L, Rajewsky K., Free PMC Article | 01/21/2010 |