| The effect of IGFBP3 gene knockout by the CRISPR/Cas9 system on the IGF-1 pathway in murine cells. | The effect of IGFBP3 gene knockout by the CRISPR/Cas9 system on the IGF-1 pathway in murine cells.
Eom SY, Kim MM. | 08/7/2024 |
| Unraveling IGFBP3-mediated m6A modification in fracture healing. | Unraveling IGFBP3-mediated m6A modification in fracture healing.
Lai A, Sun J, Dai Z, Guo L, Tao D, Li H, Chen B, Zhou R. | 03/15/2024 |
| IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor/insulin signaling. | IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor/insulin signaling.
Wang X, Li J, Zhang W, Wang F, Wu Y, Guo Y, Wang D, Yu X, Li A, Li F, Xie Y., Free PMC Article | 05/19/2023 |
| Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3. | Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3.
Sun H, Wang S, Yang Z, Tian L, Li X, Zhou J, Wang B. | 04/28/2023 |
| IGFBP3 epigenetic promotion induced by METTL3 boosts cardiac fibroblast activation and fibrosis. | IGFBP3 epigenetic promotion induced by METTL3 boosts cardiac fibroblast activation and fibrosis.
Ding JF, Sun H, Song K, Zhou Y, Tu B, Shi KH, Lu D, Xu SS, Tao H. | 02/14/2023 |
| Insulin-like Growth Factor Binding Protein 3 Increases Mouse Preimplantation Embryo Cleavage Rate by Activation of IGF1R and EGFR Independent of IGF1 Signalling. | Insulin-like Growth Factor Binding Protein 3 Increases Mouse Preimplantation Embryo Cleavage Rate by Activation of IGF1R and EGFR Independent of IGF1 Signalling.
Green CJ, Span M, Rayhanna MH, Perera M, Day ML., Free PMC Article | 12/31/2022 |
| IGFBP-3 Regulates Mitochondrial Hyperfusion and Metabolic Activity in Ocular Surface Epithelia during Hyperosmolar Stress. | IGFBP-3 Regulates Mitochondrial Hyperfusion and Metabolic Activity in Ocular Surface Epithelia during Hyperosmolar Stress.
Stuard WL, Guner MK, Robertson DM., Free PMC Article | 04/23/2022 |
| Insulin-like growth factor-binding protein 3 inhibits angiotensin II-induced aortic smooth muscle cell phenotypic switch and matrix metalloproteinase expression. | Insulin-like growth factor-binding protein 3 inhibits angiotensin II-induced aortic smooth muscle cell phenotypic switch and matrix metalloproteinase expression.
Chen S, Chen H, Zhong Y, Ge Y, Li C, Qiao Z, Zhu J. | 04/2/2022 |
| Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting. | Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.
Cole CL, Bachman JF, Ye J, Murphy J, Gerber SA, Beck CA, Boyce BF, Muthukrishnan G, Chakkalakal JV, Schwarz EM, Linehan D., Free PMC Article | 12/4/2021 |
| The contrasting effects on tumor establishment and progression of IGFBP-3 expressed by mammary carcinoma cells, compared to systemic stromal and circulating IGFBP-3, highlights the complexity of growth regulation by IGFBP-3 in mammary tumors. | Contrasting effects of IGF binding protein-3 expression in mammary tumor cells and the tumor microenvironment.
Scully T, Scott CD, Firth SM, Pintar JE, Twigg SM, Baxter RC. | 05/9/2020 |
| Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature. | Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature.
Jiang Y, Liu L, Steinle JJ., Free PMC Article | 06/1/2019 |
| IGFBP-3 inhibits osteoblast differentiation through the BMP-2 signal pathway. | Insulin-like growth factor binding Protein-3 suppresses osteoblast differentiation via bone morphogenetic protein-2.
Eguchi K, Akiba Y, Akiba N, Nagasawa M, Cooper LF, Uoshima K. | 05/18/2019 |
| The results of this study provide an immune-based mechanism by which host IGFBP3 may promote breast tumor growth in the EO771 murine breast cancer model, and suggest that targeting IGFBP-3 might make a novel contribution to immune therapy for breast cancer. | Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell accumulation.
Scully T, Scott CD, Firth SM, Sedger LM, Pintar JE, Twigg SM, Baxter RC. | 02/2/2019 |
| Igfbp3-null mouse model was generated in combination with Kras(G12D) to compare the tumor burden. Then, IGF-dependent signaling was assessed after expressing wild-type or a mutant IGFBP3 without IGF binding capacity in non-small cell lung cancer (NSCLC) cells | IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling.
Wang YA, Sun Y, Palmer J, Solomides C, Huang LC, Shyr Y, Dicker AP, Lu B. | 04/7/2018 |
| endogenous (circulating and/or stromal) IGFBP-3 is stimulatory to adipose tissue expansion and enhances mammary tumor growth in immune-competent mice, potentially by suppressing T-cell infiltration into tumors. | Insulin-like growth factor binding protein-3 links obesity and breast cancer progression.
Scully T, Firth SM, Scott CD, de Silva HC, Pintar JE, Chan-Ling T, Twigg SM, Baxter RC., Free PMC Article | 02/10/2018 |
| High Igfbp3 expression is associated with skin squamous cell carcinoma. | Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.
Canel M, Byron A, Sims AH, Cartier J, Patel H, Frame MC, Brunton VG, Serrels B, Serrels A., Free PMC Article | 10/28/2017 |
| The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt pathway and depends upon the presence of CD44, a receptor protein known to modulate Wnt signaling. | IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells.
Naspi A, Zingariello M, Sancillo L, Panasiti V, Polinari D, Martella M, Rosa Alba R, Londei P., Free PMC Article | 09/2/2017 |
| IGFBP-3 influences severity of DSS-induced colitis. | A phenotype of IGFBP-3 knockout mice revealed by dextran sulfate-induced colitis.
Yancu D, Blouin MJ, Birman E, Florianova L, Aleynikova O, Zakikhani M, VanderMeulen H, Seidman E, Pollak M. | 07/29/2017 |
| our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain | Insulin-Like Growth Factor Binding Protein-3 Deficiency Leads to Behavior Impairment with Monoaminergic and Synaptic Dysfunction.
Dai H, Goto YI, Itoh M. | 05/20/2017 |
| IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury. | Aggravation of post-ischemic liver injury by overexpression of insulin-like growth factor binding protein 3.
Zhou L, Koh HW, Bae UJ, Park BH., Free PMC Article | 05/28/2016 |
| An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage. | Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina.
Jiang Y, Pagadala J, Miller DD, Steinle JJ., Free PMC Article | 02/13/2016 |
| Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis. | Germ line knockout of IGFBP-3 reveals influences of the gene on mammary gland neoplasia.
Blouin MJ, Bazile M, Birman E, Zakikhani M, Florianova L, Aleynikova O, Powell DR, Pollak M. | 10/31/2015 |
| Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC migration. | Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration.
Mannaerts I, Schroyen B, Verhulst S, Van Lommel L, Schuit F, Nyssen M, van Grunsven LA., Free PMC Article | 09/20/2014 |
| Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development. | Expression of insulin-like growth factor binding proteins during mouse cochlear development.
Okano T, Kelley MW. | 04/19/2014 |
| IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy. | Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.
Jarajapu YP, Cai J, Yan Y, Li Calzi S, Kielczewski JL, Hu P, Shaw LC, Firth SM, Chan-Ling T, Boulton ME, Baxter RC, Grant MB., Free PMC Article | 03/23/2013 |