| Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry. | Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.
Lim JL, Ng EY, Lim SY, Tan AH, Abdul-Aziz Z, Ibrahim KA, Gopalai AA, Tay YW, Vijayanathan Y, Toh TS, Lim SK, Bee PC, Puvanarajah SD, Viswanathan S, Looi I, Lim TT, Eow GB, Cheah WK, Tan EK, Ahmad-Annuar A. | 09/25/2021 |
| Roles of DGKs in neurons: Postsynaptic functions? | Roles of DGKs in neurons: Postsynaptic functions?
Barber CN, Raben DM., Free PMC Article | 02/2/2021 |
| these data demonstrate that DGKtheta; plays an important role in steroid hormone production in human adrenocortical cells | Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells.
Cai K, Lucki NC, Sewer MB., Free PMC Article | 05/31/2014 |
| The SF1 and SREBP1 activate DGKtheta; transcription in a cAMP-dependent manner in human adrenocortical cells. | cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1.
Cai K, Sewer MB., Free PMC Article | 03/1/2014 |
| This study found that the minor alleles of GAK rs1564282 and DGKQ rs11248060 significantly increase the risk of PD in Han Chinese populations. | GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population.
Chen YP, Song W, Huang R, Chen K, Zhao B, Li J, Yang Y, Shang HF. | 01/11/2014 |
| Data suggest that diacylglycerol kinase theta is a key mediator of bile-acid-stimulated modulation of farnesoid X receptor/mTOR complex 2/Akt signaling pathway and glucose metabolism/homoeostasis in hepatocytes. | Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes.
Cai K, Sewer MB., Free PMC Article | 11/16/2013 |
| DGKtheta; translocation and activity is regulated by the concerted activity of EGFR and PKC. | Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.
van Baal J, de Widt J, Divecha N, van Blitterswijk WJ. | 03/30/2013 |
| DGK-theta; directly interacts with, and is activated by, basic proteins such as histone H1 and Tau with nm affinity, consistent with a potential role for a polybasic protein or protein domain in the activation of this enzyme. | Dual regulation of diacylglycerol kinase (DGK)-θ: polybasic proteins promote activation by phospholipids and increase substrate affinity.
Tu-Sekine B, Raben DM., Free PMC Article | 02/16/2013 |
| Data show that cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. | Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
Li D, Urs AN, Allegood J, Leon A, Merrill AH Jr, Sewer MB., Free PMC Article | 01/21/2010 |
| Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles. | Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.
Tabellini G, Bortul R, Santi S, Riccio M, Baldini G, Cappellini A, Billi AM, Berezney R, Ruggeri A, Cocco L, Martelli AM. | 01/21/2010 |
| DGK interacts selectively with and is phosphorylated by PKCepsilon and -eta and peptide agonist-induced selective activation of PKCepsilon directly leads to DGK translocation | Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.
van Baal J, de Widt J, Divecha N, van Blitterswijk WJ. | 01/21/2010 |