| Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen. | Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T(H)2 cells in response to inhaled allergen.
He K, Xiao H, MacDonald WA, Mehta I, Kishore A, Vincent A, Xu Z, Ray A, Chen W, Weaver CT, Lambrecht BN, Das J, Poholek AC. | 11/7/2024 |
| Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. | Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.
Lin JX, Ge M, Liu CY, Holewinski R, Andresson T, Yu ZX, Gebregiorgis T, Spolski R, Li P, Leonard WJ., Free PMC Article | 08/28/2024 |
| Long-lasting mRNA-encoded interleukin-2 restores CD8[+] T cell neoantigen immunity in MHC class I-deficient cancers. | Long-lasting mRNA-encoded interleukin-2 restores CD8(+) T cell neoantigen immunity in MHC class I-deficient cancers.
Beck JD, Diken M, Suchan M, Streuber M, Diken E, Kolb L, Allnoch L, Vascotto F, Peters D, Beißert T, Akilli-Öztürk Ö, Türeci Ö, Kreiter S, Vormehr M, Sahin U. | 04/16/2024 |
| PD-1 Limits IL-2 Production and Thymic Regulatory T Cell Development. | PD-1 Limits IL-2 Production and Thymic Regulatory T Cell Development.
Caruso B, Weeder BR, Thompson RF, Moran AE., Free PMC Article | 04/5/2024 |
| Tumor-infiltrating mast cells stimulate ICOS[+] regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression. | Tumor-infiltrating mast cells stimulate ICOS(+) regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.
Lv Y, Tian W, Teng Y, Wang P, Zhao Y, Li Z, Tang S, Chen W, Xie R, Lü M, Zhuang Y., Free PMC Article | 03/4/2024 |
| Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. | Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF., Free PMC Article | 02/23/2024 |
| Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells. | Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.
Shapiro MR, Peters LD, Brown ME, Cabello-Kindelan C, Posgai AL, Bayer AL, Brusko TM., Free PMC Article | 09/20/2023 |
| Stimulation of ectopically expressed muscarinic receptors induces IFN-gamma but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells. | Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.
Nguyen TTT, Lu W, Zhu WS, Ansel KM, Liang HE, Weiss A., Free PMC Article | 06/14/2023 |
| Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2. | Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2.
Depew CE, Rixon JA, McSorley SJ., Free PMC Article | 04/14/2023 |
| Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2. | Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.
Tsyklauri O, Chadimova T, Niederlova V, Kovarova J, Michalik J, Malatova I, Janusova S, Ivashchenko O, Rossez H, Drobek A, Vecerova H, Galati V, Kovar M, Stepanek O., Free PMC Article | 03/4/2023 |
| TGF-beta2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma. | TGF-β2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma.
Lee HK, Nam MW, Go RE, Koo J, Kim TH, Park JE, Choi KC. | 02/25/2023 |
| Dopaminergic Signalling Enhances IL-2 Production and Strengthens Anti-Tumour Response Exerted by Cytotoxic T Lymphocytes in a Melanoma Mouse Model. | Dopaminergic Signalling Enhances IL-2 Production and Strengthens Anti-Tumour Response Exerted by Cytotoxic T Lymphocytes in a Melanoma Mouse Model.
Chovar-Vera O, López E, Gálvez-Cancino F, Prado C, Franz D, Figueroa DA, Espinoza A, Figueroa C, Lladser A, Pacheco R., Free PMC Article | 12/24/2022 |
| Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-beta and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression. | Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Huang C, Zhang F, Li P, Song C., Free PMC Article | 12/10/2022 |
| Diversity-Oriented Synthesis of a Molecular Library of Immunomodulatory alpha-Galactosylceramides with Fluorous-Tag-Assisted Purification and Evaluation of Their Bioactivities in Regard to IL-2 Secretion. | Diversity-Oriented Synthesis of a Molecular Library of Immunomodulatory α-Galactosylceramides with Fluorous-Tag-Assisted Purification and Evaluation of Their Bioactivities in Regard to IL-2 Secretion.
Chen YN, Hung JT, Jan FD, Su YY, Hwu JR, Yu AL, Adak AK, Lin CC., Free PMC Article | 11/29/2022 |
| IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4(+)Foxp3(+) regulatory T lymphocytes. | IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4(+)Foxp3(+) regulatory T lymphocytes.
Apert C, Galindo-Albarrán AO, Castan S, Detraves C, Michaud H, McJannett N, Haegeman B, Fillatreau S, Malissen B, Holländer G, Žuklys S, Santamaria JC, Joffre OP, Romagnoli P, van Meerwijk JPM., Free PMC Article | 10/8/2022 |
| The antitumor effect induced by an IL-2 'no-alpha' mutein depends on changes in the CD8(+) T lymphocyte/Treg cell balance. | The antitumor effect induced by an IL-2 'no-alpha' mutein depends on changes in the CD8(+) T lymphocyte/Treg cell balance.
Carmenate T, Montalvo G, Lozada SL, Rodriguez Y, Ortiz Y, Díaz C, Avellanet J, Kim J, Surh CD, Graça L, León K., Free PMC Article | 09/17/2022 |
| Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits. | Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits.
Whyte CE, Singh K, Burton OT, Aloulou M, Kouser L, Veiga RV, Dashwood A, Okkenhaug H, Benadda S, Moudra A, Bricard O, Lienart S, Bielefeld P, Roca CP, Naranjo-Galindo FJ, Lombard-Vadnais F, Junius S, Bending D, Ono MM, Hochepied T, Halim TYF, Schlenner S, Lesage S, Dooley J, Liston A., Free PMC Article | 07/2/2022 |
| Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity. | Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity.
Ren Z, Zhang A, Sun Z, Liang Y, Ye J, Qiao J, Li B, Fu YX., Free PMC Article | 04/2/2022 |
| Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability. | Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability.
Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gilmore SA, Khan S, Baca M, Vivier E, Gasteiger G, Kuka M, Guidotti LG, Iannacone M. | 03/12/2022 |
| Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. | Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection.
Kahan SM, Bakshi RK, Ingram JT, Hendrickson RC, Lefkowitz EJ, Crossman DK, Harrington LE, Weaver CT, Zajac AJ., Free PMC Article | 03/12/2022 |
| The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role. | The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role.
Nihei J, Cardillo F, Mengel J., Free PMC Article | 02/5/2022 |
| Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity. | Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity.
Pyle CJ, Labeur-Iurman L, Groves HT, Puttur F, Lloyd CM, Tregoning JS, Harker JA., Free PMC Article | 01/1/2022 |
| Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling. | Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling.
Mendu SK, Stremska ME, Schappe MS, Moser EK, Krupa JK, Rogers JS, Stipes EJ, Parker CA, Braciale TJ, Perry JSA, Desai BN., Free PMC Article | 11/13/2021 |
| The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease. | The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease.
Chen Y, Shao C, Fan NW, Nakao T, Amouzegar A, Chauhan SK, Dana R., Free PMC Article | 10/16/2021 |
| Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance. | Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance.
Hirai T, Ramos TL, Lin PY, Simonetta F, Su LL, Picton LK, Baker J, Lin JX, Li P, Seo K, Lohmeyer JK, Bolivar-Wagers S, Mavers M, Leonard WJ, Blazar BR, Garcia KC, Negrin RS., Free PMC Article | 10/2/2021 |